{"title":"负压闭合引流联合开放植骨或骨迁移治疗胫骨外伤性骨髓炎及其对血清CRP、TNF-α、IL-6水平的影响","authors":"Xinqiang Wang, Liangbang Wu, Yuehong Zhang, Zhenhai Hou, Longbao Zheng, Zenghui Gu","doi":"10.4314/ahs.v23i3.55","DOIUrl":null,"url":null,"abstract":"Objective: To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration inthe treatment of tibial traumatic osteomyelitis.
 Methods: Eighty-six (86) cases of tibial traumatic osteomyelitis admitted to Hospital of the Chinese people's Liberation Armyfrom September 2017 to September 2018 were randomly divided into control group and observation group, forty-three (43)cases each. Debridement, open bone grafting or bone migration was given to the control group.The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serumcomponents such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery.
 Results: Observation group granulation cover wound, fracture healing time was shorter than the control group, fracture healingrate was better than the control group, the difference has statistical significance (P<0.05). By comparing serum CRP, TNF-α,IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the controlgroup (P<0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P<0.05).
 Conclusion: The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bonegrafting or bone displacement has a good effect on fracture healing and is worth popularizing.
 Keywords: Bone removal; CRP; IL-6; Negative pressure closure drainage; Tibia; TNF-α; Traumatic osteomyelitis.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"125 1","pages":"0"},"PeriodicalIF":0.8000,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone migration and its effect on the levels of CRP, TNF-α and IL-6 in the serum\",\"authors\":\"Xinqiang Wang, Liangbang Wu, Yuehong Zhang, Zhenhai Hou, Longbao Zheng, Zenghui Gu\",\"doi\":\"10.4314/ahs.v23i3.55\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration inthe treatment of tibial traumatic osteomyelitis.
 Methods: Eighty-six (86) cases of tibial traumatic osteomyelitis admitted to Hospital of the Chinese people's Liberation Armyfrom September 2017 to September 2018 were randomly divided into control group and observation group, forty-three (43)cases each. Debridement, open bone grafting or bone migration was given to the control group.The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serumcomponents such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery.
 Results: Observation group granulation cover wound, fracture healing time was shorter than the control group, fracture healingrate was better than the control group, the difference has statistical significance (P<0.05). By comparing serum CRP, TNF-α,IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the controlgroup (P<0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P<0.05).
 Conclusion: The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bonegrafting or bone displacement has a good effect on fracture healing and is worth popularizing.
 Keywords: Bone removal; CRP; IL-6; Negative pressure closure drainage; Tibia; TNF-α; Traumatic osteomyelitis.\",\"PeriodicalId\":7853,\"journal\":{\"name\":\"African Health Sciences\",\"volume\":\"125 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ahs.v23i3.55\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ahs.v23i3.55","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone migration and its effect on the levels of CRP, TNF-α and IL-6 in the serum
Objective: To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration inthe treatment of tibial traumatic osteomyelitis.
Methods: Eighty-six (86) cases of tibial traumatic osteomyelitis admitted to Hospital of the Chinese people's Liberation Armyfrom September 2017 to September 2018 were randomly divided into control group and observation group, forty-three (43)cases each. Debridement, open bone grafting or bone migration was given to the control group.The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serumcomponents such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery.
Results: Observation group granulation cover wound, fracture healing time was shorter than the control group, fracture healingrate was better than the control group, the difference has statistical significance (P<0.05). By comparing serum CRP, TNF-α,IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the controlgroup (P<0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P<0.05).
Conclusion: The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bonegrafting or bone displacement has a good effect on fracture healing and is worth popularizing.
Keywords: Bone removal; CRP; IL-6; Negative pressure closure drainage; Tibia; TNF-α; Traumatic osteomyelitis.
期刊介绍：
The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.
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