Nadia Touil, Charifa Drissi Touzani, El Mostafa Benaissa, Jalal Kasouati, Zineb Rhazzar, Hicham El Annaz, Nadia El Mrimar, Lamiae Neffah, Rachid Abi, Rida Tagajdid Rida Tagajdid, Safae El Kochri, Mariette Ducatez, Youssouf Akhouad, Ahmed Reggad, Zouhour El Kassimi, Abdelhamid Zrara, Fatna Bssaibis, ElMostapha El Fahime, Idriss Lahlou Amine, Abdelkader Belmekki, Yashpal Singh Malik, Mostafa Elouennass, Khalid Ennibi
{"title":"针对SARS-CoV-2的中和抗体提供了2020年3月至2021年2月摩洛哥拉巴特Covid-19流行演变的重要信息","authors":"Nadia Touil, Charifa Drissi Touzani, El Mostafa Benaissa, Jalal Kasouati, Zineb Rhazzar, Hicham El Annaz, Nadia El Mrimar, Lamiae Neffah, Rachid Abi, Rida Tagajdid Rida Tagajdid, Safae El Kochri, Mariette Ducatez, Youssouf Akhouad, Ahmed Reggad, Zouhour El Kassimi, Abdelhamid Zrara, Fatna Bssaibis, ElMostapha El Fahime, Idriss Lahlou Amine, Abdelkader Belmekki, Yashpal Singh Malik, Mostafa Elouennass, Khalid Ennibi","doi":"10.4314/ahs.v23i3.46","DOIUrl":null,"url":null,"abstract":"Background: The SARS-CoV-2 is an extremely contagious and acute viral disease mainly affecting humans.
 Objective: To estimate seroprevalence of SARS-CoV-2 neutralizing antibodies (NAbs) for illegible armed force individuals living in Rabat, Morocco
 Method: A convenience sample (N = 2662) was conducted from May 2020 to February 2021. We used the standard neutralization assay to quantify the NAbs titers. A serum was positive when the titer was 1:4. High positive NAbs titers were defined when ≥ 1:32.
 Results: Demographic and socioeconomic status did not affect seroprevalence data. An overall seroprevalence of 24,9% was found. Sera from blood donors, young recruits and auto-immune population had lower NAbs titers. However, titers were above 1:16 in 9% of the population with high risk of SARS-CoV-2 exposure. Seropositivity increased over time with values reaching peaks after the epidemic waves (2.4% in May 2020; 16.2% in August 2020; 22.7% in December 2020 and 37% in February 2021).
 Conclusion: And increase of NAbs was observed over time and correlated with the post-epidemic waves of COVID-19 in Morocco.
 Keywords: SARS-CoV-2; Serum neutralizing assay; Seroprevalence; Rabat; Morocco.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.8000,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neutralising antibodies against SARS-CoV-2 give important information on Covid-19 epidemic evolution in Rabat, Morocco, March 2020-February 2021\",\"authors\":\"Nadia Touil, Charifa Drissi Touzani, El Mostafa Benaissa, Jalal Kasouati, Zineb Rhazzar, Hicham El Annaz, Nadia El Mrimar, Lamiae Neffah, Rachid Abi, Rida Tagajdid Rida Tagajdid, Safae El Kochri, Mariette Ducatez, Youssouf Akhouad, Ahmed Reggad, Zouhour El Kassimi, Abdelhamid Zrara, Fatna Bssaibis, ElMostapha El Fahime, Idriss Lahlou Amine, Abdelkader Belmekki, Yashpal Singh Malik, Mostafa Elouennass, Khalid Ennibi\",\"doi\":\"10.4314/ahs.v23i3.46\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The SARS-CoV-2 is an extremely contagious and acute viral disease mainly affecting humans.
 Objective: To estimate seroprevalence of SARS-CoV-2 neutralizing antibodies (NAbs) for illegible armed force individuals living in Rabat, Morocco
 Method: A convenience sample (N = 2662) was conducted from May 2020 to February 2021. We used the standard neutralization assay to quantify the NAbs titers. A serum was positive when the titer was 1:4. High positive NAbs titers were defined when ≥ 1:32.
 Results: Demographic and socioeconomic status did not affect seroprevalence data. An overall seroprevalence of 24,9% was found. Sera from blood donors, young recruits and auto-immune population had lower NAbs titers. However, titers were above 1:16 in 9% of the population with high risk of SARS-CoV-2 exposure. Seropositivity increased over time with values reaching peaks after the epidemic waves (2.4% in May 2020; 16.2% in August 2020; 22.7% in December 2020 and 37% in February 2021).
 Conclusion: And increase of NAbs was observed over time and correlated with the post-epidemic waves of COVID-19 in Morocco.
 Keywords: SARS-CoV-2; Serum neutralizing assay; Seroprevalence; Rabat; Morocco.\",\"PeriodicalId\":7853,\"journal\":{\"name\":\"African Health Sciences\",\"volume\":\"3 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ahs.v23i3.46\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ahs.v23i3.46","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Neutralising antibodies against SARS-CoV-2 give important information on Covid-19 epidemic evolution in Rabat, Morocco, March 2020-February 2021
Background: The SARS-CoV-2 is an extremely contagious and acute viral disease mainly affecting humans.
Objective: To estimate seroprevalence of SARS-CoV-2 neutralizing antibodies (NAbs) for illegible armed force individuals living in Rabat, Morocco
Method: A convenience sample (N = 2662) was conducted from May 2020 to February 2021. We used the standard neutralization assay to quantify the NAbs titers. A serum was positive when the titer was 1:4. High positive NAbs titers were defined when ≥ 1:32.
Results: Demographic and socioeconomic status did not affect seroprevalence data. An overall seroprevalence of 24,9% was found. Sera from blood donors, young recruits and auto-immune population had lower NAbs titers. However, titers were above 1:16 in 9% of the population with high risk of SARS-CoV-2 exposure. Seropositivity increased over time with values reaching peaks after the epidemic waves (2.4% in May 2020; 16.2% in August 2020; 22.7% in December 2020 and 37% in February 2021).
Conclusion: And increase of NAbs was observed over time and correlated with the post-epidemic waves of COVID-19 in Morocco.
Keywords: SARS-CoV-2; Serum neutralizing assay; Seroprevalence; Rabat; Morocco.
期刊介绍：
The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.
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