自旋标记TEPA和CCNU类似物对sd大鼠骨肉瘤和mnu诱导的乳腺癌的作用。

Archiv fur Geschwulstforschung Pub Date : 1989-01-01

T Klenner, M R Berger, G Sosnovsky, N U Rao, F Wingen, D Schmähl

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引用次数: 0

摘要

研究了1-(2-氯乙基)-3-(1-氧基-2,2,6,6-四甲基哌替啶基)- 1-亚硝基脲(SLCNU)和N,N,N，'N'-双(1,2-乙二基)-N"-(1-氧基-2,2,6,6-四甲基-2 -哌替啶基氨基羰基)-磷酸三酰胺(SLDU)对sd大鼠骨肉瘤和mnu诱导的乳腺癌的抑制作用。与对照组相比，这两种化合物既没有对这些肿瘤产生抑制作用，也没有增加平均/中位寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evaluation of spin labeled TEPA and CCNU analogs against osteosarcoma and MNU-induced mammary carcinoma of the SD-rat.

The effectiveness to reduce tumor growth by 1-(2-chloroethyl)-3-(1-oxyl-2,2,6,6-tetramethylpiperidinyl)- 1-nitrosourea (SLCNU) and N,N,N,'N'- bis(1,2-ethanediyl)-N"-(1-oxyl-2,2,6,6-tetramethyl- 2-piperidinylaminocarbonyl)-phosphoric triamide (SLDU) was studied in osteosarcoma and MNU-induced mammary carcinoma in the SD-rat. Both compounds elicited neither an inhibitory effect on these tumors nor an increase in the mean/median life span as compared to the control group.

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Archiv fur Geschwulstforschung

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