Heba Rashad, Aya Abdel monem, Mohebat Gouda, Taghreed Abdelaziz
{"title":"Dicer1在肾上腺皮质腺瘤和癌中的意义(免疫组化研究)","authors":"Heba Rashad, Aya Abdel monem, Mohebat Gouda, Taghreed Abdelaziz","doi":"10.21608/bmfj.2023.228490.1875","DOIUrl":null,"url":null,"abstract":": Background: Adrenocortical tumors (ACTs) are detected in 5– 7% of the general population. Dysregulation of micro-ribonucleic acid (microRNA) biogenesis machinery-is involved in a variety of human cancers. Dicer1 is an essential component of microRNA machinery. Aim: To evaluate the diagnostic and prognostic significance of Dicer1 in adrenocortical adenoma (ACA) and carcinoma (ACC), then correlate the results with clinico-pathological data. Material and Methods: Forty adrenocortical lesions were included in this retrospective study, included (20) ACA and (20) ACC. Clinicopathological characteristics of examined cases were correlated with the IHC expression of Dicer1. Results: Dicer1 IHC expression was more frequent in ACC (65%) than in ACA (25%), (P =0.04). But among ACC, a weak Dicer1 expression was significantly more frequent in advanced ACCs. There was a significant statistical inverse relation between Dicer1 expression in studied ACC cases according to tumor size, weight, Weiss score, lymph node metastasis, lympho-vascular invasion and ENSAT stage (P <0.05). Other clinico-pathological variables such as age, sex, tumor site, tumor grade, and distant metastasis showed no significant statistical difference (P >0.05). Dicer1 showed 76% sensitivity and 67% specificity for differentiating ACA from ACC. Conclusion: Reduced Dicer1 expression with tumor progression in ACC may play a role in the tumorigenesis and further decline in Dicer1 expression may be associated with poor prognosis in ACC.","PeriodicalId":8803,"journal":{"name":"Benha Veterinary Medical Journal","volume":"3 5","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Significance of Dicer1 in Adrenocortical Adenoma and Carcinoma (Immunohistochemical Study)\",\"authors\":\"Heba Rashad, Aya Abdel monem, Mohebat Gouda, Taghreed Abdelaziz\",\"doi\":\"10.21608/bmfj.2023.228490.1875\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Background: Adrenocortical tumors (ACTs) are detected in 5– 7% of the general population. Dysregulation of micro-ribonucleic acid (microRNA) biogenesis machinery-is involved in a variety of human cancers. Dicer1 is an essential component of microRNA machinery. Aim: To evaluate the diagnostic and prognostic significance of Dicer1 in adrenocortical adenoma (ACA) and carcinoma (ACC), then correlate the results with clinico-pathological data. Material and Methods: Forty adrenocortical lesions were included in this retrospective study, included (20) ACA and (20) ACC. Clinicopathological characteristics of examined cases were correlated with the IHC expression of Dicer1. Results: Dicer1 IHC expression was more frequent in ACC (65%) than in ACA (25%), (P =0.04). But among ACC, a weak Dicer1 expression was significantly more frequent in advanced ACCs. There was a significant statistical inverse relation between Dicer1 expression in studied ACC cases according to tumor size, weight, Weiss score, lymph node metastasis, lympho-vascular invasion and ENSAT stage (P <0.05). Other clinico-pathological variables such as age, sex, tumor site, tumor grade, and distant metastasis showed no significant statistical difference (P >0.05). Dicer1 showed 76% sensitivity and 67% specificity for differentiating ACA from ACC. Conclusion: Reduced Dicer1 expression with tumor progression in ACC may play a role in the tumorigenesis and further decline in Dicer1 expression may be associated with poor prognosis in ACC.\",\"PeriodicalId\":8803,\"journal\":{\"name\":\"Benha Veterinary Medical Journal\",\"volume\":\"3 5\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Benha Veterinary Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/bmfj.2023.228490.1875\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Benha Veterinary Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/bmfj.2023.228490.1875","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Significance of Dicer1 in Adrenocortical Adenoma and Carcinoma (Immunohistochemical Study)
: Background: Adrenocortical tumors (ACTs) are detected in 5– 7% of the general population. Dysregulation of micro-ribonucleic acid (microRNA) biogenesis machinery-is involved in a variety of human cancers. Dicer1 is an essential component of microRNA machinery. Aim: To evaluate the diagnostic and prognostic significance of Dicer1 in adrenocortical adenoma (ACA) and carcinoma (ACC), then correlate the results with clinico-pathological data. Material and Methods: Forty adrenocortical lesions were included in this retrospective study, included (20) ACA and (20) ACC. Clinicopathological characteristics of examined cases were correlated with the IHC expression of Dicer1. Results: Dicer1 IHC expression was more frequent in ACC (65%) than in ACA (25%), (P =0.04). But among ACC, a weak Dicer1 expression was significantly more frequent in advanced ACCs. There was a significant statistical inverse relation between Dicer1 expression in studied ACC cases according to tumor size, weight, Weiss score, lymph node metastasis, lympho-vascular invasion and ENSAT stage (P <0.05). Other clinico-pathological variables such as age, sex, tumor site, tumor grade, and distant metastasis showed no significant statistical difference (P >0.05). Dicer1 showed 76% sensitivity and 67% specificity for differentiating ACA from ACC. Conclusion: Reduced Dicer1 expression with tumor progression in ACC may play a role in the tumorigenesis and further decline in Dicer1 expression may be associated with poor prognosis in ACC.