{"title":"新的双核 Cu (II) 复合物：合成、结构阐明、细胞毒性和 DNA 结合评估","authors":"Mouayed A. Hussein, Adyan A. Yaseen","doi":"10.1007/s11243-023-00561-8","DOIUrl":null,"url":null,"abstract":"<div><p>A novel copper complex [Cu(μ<sub>2</sub>–OH)(1,10-phenanthroline)(4-aminobenzenesulfonic acid)·3H<sub>2</sub>O]<sub>2</sub> (<b>1</b>) was synthesized and characterized by X-ray single-crystal diffraction, elemental analysis and IR spectroscopy. X-ray crystallography of complex <b>1</b> showed strictly planar bridged μ<sub>2</sub>–Cu<sub>2</sub>(OH)<sub>2</sub> core where copper (II) center exhibited a distorted square pyramidal coordination geometry. The interaction of the complex with calf thymus DNA (CT DNA) was investigated by absorption titration and viscosity measurement. The results revealed an intercalation binding between DNA and complex <b>1</b> with a binding strength of 6.0731 × 10<sup>6</sup> ± 0.0032 M<sup>−1</sup>. The antitumor capacity of the complex was tested in vitro against human colorectal (HCT 116) cancer cell lines by metabolic tests, using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide reagent. Complex <b>1</b> showed remarkably low IC<sub>50</sub> values of 4.844 ± 0.025 μM compared to 5-fluorouracil (7.3 μM), a widely used clinical antitumor drug.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"49 1","pages":"53 - 62"},"PeriodicalIF":1.6000,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New binuclear Cu (II) complex: synthesis, structural elucidation, cytotoxic and DNA-binding evaluation\",\"authors\":\"Mouayed A. Hussein, Adyan A. Yaseen\",\"doi\":\"10.1007/s11243-023-00561-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A novel copper complex [Cu(μ<sub>2</sub>–OH)(1,10-phenanthroline)(4-aminobenzenesulfonic acid)·3H<sub>2</sub>O]<sub>2</sub> (<b>1</b>) was synthesized and characterized by X-ray single-crystal diffraction, elemental analysis and IR spectroscopy. X-ray crystallography of complex <b>1</b> showed strictly planar bridged μ<sub>2</sub>–Cu<sub>2</sub>(OH)<sub>2</sub> core where copper (II) center exhibited a distorted square pyramidal coordination geometry. The interaction of the complex with calf thymus DNA (CT DNA) was investigated by absorption titration and viscosity measurement. The results revealed an intercalation binding between DNA and complex <b>1</b> with a binding strength of 6.0731 × 10<sup>6</sup> ± 0.0032 M<sup>−1</sup>. The antitumor capacity of the complex was tested in vitro against human colorectal (HCT 116) cancer cell lines by metabolic tests, using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide reagent. Complex <b>1</b> showed remarkably low IC<sub>50</sub> values of 4.844 ± 0.025 μM compared to 5-fluorouracil (7.3 μM), a widely used clinical antitumor drug.</p></div>\",\"PeriodicalId\":803,\"journal\":{\"name\":\"Transition Metal Chemistry\",\"volume\":\"49 1\",\"pages\":\"53 - 62\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-10-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transition Metal Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11243-023-00561-8\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-023-00561-8","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
New binuclear Cu (II) complex: synthesis, structural elucidation, cytotoxic and DNA-binding evaluation
A novel copper complex [Cu(μ2–OH)(1,10-phenanthroline)(4-aminobenzenesulfonic acid)·3H2O]2 (1) was synthesized and characterized by X-ray single-crystal diffraction, elemental analysis and IR spectroscopy. X-ray crystallography of complex 1 showed strictly planar bridged μ2–Cu2(OH)2 core where copper (II) center exhibited a distorted square pyramidal coordination geometry. The interaction of the complex with calf thymus DNA (CT DNA) was investigated by absorption titration and viscosity measurement. The results revealed an intercalation binding between DNA and complex 1 with a binding strength of 6.0731 × 106 ± 0.0032 M−1. The antitumor capacity of the complex was tested in vitro against human colorectal (HCT 116) cancer cell lines by metabolic tests, using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide reagent. Complex 1 showed remarkably low IC50 values of 4.844 ± 0.025 μM compared to 5-fluorouracil (7.3 μM), a widely used clinical antitumor drug.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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