影响犬肠道的胃肠道间质瘤和其他肉瘤的组织形态学和免疫表型诊断

Marina Laudares Costa, Felipe Augusto Ruiz Sueiro, Paulo César Jark, Leonardo Lamarca de Carvalho, Marcela Aldrovani Rodrigues, Vinícius Thomaz da Silva Almeida, Fernanda Gosuen Gonçalves Dias
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摘要

摘要针对犬胃肠道间质瘤(GIST)与其他肠道肉瘤在形态上的相似性,结合犬种、性别、年龄、部位及肿瘤侵袭情况,对胃肠道间质瘤进行组织形态学及免疫组化诊断。经组织病理学检查217例,经免疫组化诊断36例(GIST 24例,其他肠肉瘤12例)。胃肠道间质瘤的诊断以杂交犬居多,以高龄犬(9.5±2.2岁)为主;在其他肠道肉瘤中,杂交犬和腊肠犬,雄性和雌性,受到的影响是一样的。盲肠是胃肠道间质瘤的主要受累部位,所有病例均有肿瘤侵袭肠层。小肠受其他肠道肉瘤的影响最大,这些肿瘤大多侵袭肠壁。与其他肠肉瘤不同,gist表达CD117和DOG-1等标志物。胃肠道间质瘤和其他肠肉瘤表现出与组织病理学相似的组织形态学和免疫表型特征,证明了免疫组织化学与最终诊断的相关性。
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Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs
Abstract In view of the morphological similarity between gastrointestinal stromal tumors (GIST) and other sarcomas of the intestine of dogs, the aim was to carry out the histomorphological and immunohistochemical diagnosis of these tumors, associating breed, sex and age, location and tumor invasion. 217 cases were evaluated by histopathology and 36 diagnosed by immunohistochemistry were included (24 GIST and 12 other intestinal sarcomas). Mixed breed dogs were the most diagnosed with GIST, mainly elderly females (9.5±2.2 years); in the other intestinal sarcomas, crossbreeds and Dachshunds, males and females, were equally affected. The cecum was the most affected by GISTs, with tumor invasion of the intestinal layers in all cases. The small intestine was the most affected by the other intestinal sarcomas, with invasion of the layers in most of these tumors. GISTs expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas. GIST and other intestinal sarcomas denoted histomorphological and immunophenotypic characteristics similar to histopathology, justifying the association of immunohistochemistry for the definitive diagnosis.
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