CORRECTION OF THE METABOLOMIC PROFILE AND REDOX POTENTIAL IN PATIENTS WITH LOWER LIMB VARICOSE VEINS (CLASS C4 - C6) IN THE POSTOPERATIVE PERIOD

The present study evaluates the effectiveness of the use of sulodexin (SDX) and ozone therapy in the treatment of lower limb varicose veins (classes C4 to C6) based on the study of the dynamics of plasma biomarkers of oxidative homeostasis and metabolomic profile. In patients of the comparison group, changes in the TAC index in blood plasma tended to increase, however, we didn’t established any statistical significance for the entire period of the study: initially - 305.5 ± 18.6 nmol/ml, then 322.3±17.7 nmol/ml on the day 20 after SI (surgical intervention), and 341.6±18.2 nmol/ml (p=0.672) on day 45 after SI. On the contrary, patients of the main group, by the day 20 after SI, had an increase in TAC level from 305.5±18.6 nmol/ml to 365.9±18.1 nmol/ml (by 19.8% of the baseline, p=0.046 ). By the day 20 after SI, in patients of the comparison group, the SOD activity in blood plasma tended to increase from 10.8±1.8 U/ml to 13.1±1.5 U/ml (by 21.3% relative to the baseline), but no statistical significance was found (p=0.733). The proposed method of complex treatment proved to be effective in correcting oxidative homeostasis and cellular metabolomic profile in patients with LLVV (classes C4 to C6).