The purpose of this prospective single-center study was to determine the feasibility of minilaparotomy for aortoiliac segment and its effect on intraoperative and postoperative outcomes. Materials and Methods: From August 2020 to July 2022, the authors used minilaparotomy in 24 patients with aortoiliac atherosclerotic occlusive disease. The comparison group included 27 patients undergoing laparotomy. The age of the patients ranged from 58 to 83 years, among them 37 men and 14 women. In the group with traditional access, 9 aorto-bifurcational and 18 linear operations were performed; in the minimal incision group, there were 7 bifurcational and 17 linear interventions. Results and Discussion: The duration of surgery was 196.5±26.7 minutes for operations with traditional access, and 146.3±16.7 minutes in the group with minimal incision. On average, minimal incision surgeries were shorter by 52.3±14.4 minutes (p≤0.05). For patients from the group with minimal incision, the length of stay in intensive care was 1.27±0.4 days, and with traditional access 2.3±0.3 (p≤0.05). Postoperative bed stay for the group with mini-access was 6.4±0.5 days, for patients with classic access 9.2±1.2 days (p≤0.05). 4 patients in the comparison group had postoperative paresis, and in one of them it was complicated by eventration. In the long-term postoperative period, two patients in the comparison group required surgery for an incisional hernia. Conclusions: Minimal incision access to the aorta can reduce surgical trauma and intervention time, shorten the patient’s stay in the intensive care unit and postoperative bed, and minimize perioperative and postoperative complications. During repeated reconstructive interventions on the aorta, a “high” mini-access to the aorta allows to quickly reach the optimal area of the aorta for anastomosis and minimize organ trauma, as well as prevent adhesions in the abdominal cavity.
{"title":"MINIMAL INCISION SURGERY FOR THE AORTOILIAC SEGMENT – RESULTS OF A SINGLE-CENTER STUDY","authors":"Vyacheslav Mykhaylichenko, Alexander Tsaturyan, DMITRY PARSHIN, Seyfeddine Khizriev, Andrey Pilipchuk, Enver Kеrimov","doi":"10.35630/2023/13/6.604","DOIUrl":"https://doi.org/10.35630/2023/13/6.604","url":null,"abstract":"The purpose of this prospective single-center study was to determine the feasibility of minilaparotomy for aortoiliac segment and its effect on intraoperative and postoperative outcomes. Materials and Methods: From August 2020 to July 2022, the authors used minilaparotomy in 24 patients with aortoiliac atherosclerotic occlusive disease. The comparison group included 27 patients undergoing laparotomy. The age of the patients ranged from 58 to 83 years, among them 37 men and 14 women. In the group with traditional access, 9 aorto-bifurcational and 18 linear operations were performed; in the minimal incision group, there were 7 bifurcational and 17 linear interventions. Results and Discussion: The duration of surgery was 196.5±26.7 minutes for operations with traditional access, and 146.3±16.7 minutes in the group with minimal incision. On average, minimal incision surgeries were shorter by 52.3±14.4 minutes (p≤0.05). For patients from the group with minimal incision, the length of stay in intensive care was 1.27±0.4 days, and with traditional access 2.3±0.3 (p≤0.05). Postoperative bed stay for the group with mini-access was 6.4±0.5 days, for patients with classic access 9.2±1.2 days (p≤0.05). 4 patients in the comparison group had postoperative paresis, and in one of them it was complicated by eventration. In the long-term postoperative period, two patients in the comparison group required surgery for an incisional hernia. Conclusions: Minimal incision access to the aorta can reduce surgical trauma and intervention time, shorten the patient’s stay in the intensive care unit and postoperative bed, and minimize perioperative and postoperative complications. During repeated reconstructive interventions on the aorta, a “high” mini-access to the aorta allows to quickly reach the optimal area of the aorta for anastomosis and minimize organ trauma, as well as prevent adhesions in the abdominal cavity.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"107 S1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karolina Borowska-Waniak, Dominik Michalik, Anita Marcinkiewicz, Aleksandra Ochotnicka
Ocular manifestations in autoimmune diseases are mainly related to the formation of a chronic inflammatory process in the body. This is caused by an error in the body's histocompatibility system, which results in the lymphocyte attacking its own cells, which the lymphocyte considers foreign. Various autoimmune diseases with ocular symptoms may have different inflammation-related pathophysiology, ranging from increased vascular permeability in diabetic retinopathy to lymphocytic pressure in the exocrine glands in Sjögren's syndrome. The inflammatory process in the eye tissues leads to symptoms such as pain, redness, photosensitivity, tearing and reduced visual acuity. One of the most common autoimmune diseases associated with ocular symptoms is systemic lupus erythematosus, in which 50% of patients experience ocular symptoms. Ocular manifestations may worsen or improve depending on disease activity. Ophthalmological examination is extremely important for patients with autoimmune diseases because it allows for the early detection and treatment of eye-related diseases, monitoring the side effects of medications taken, and identifying other related health problems.
{"title":"MANIFESTATIONS OF OCULAR AUTOIMMUNE DISEASES - LITERATURE REVIEW","authors":"Karolina Borowska-Waniak, Dominik Michalik, Anita Marcinkiewicz, Aleksandra Ochotnicka","doi":"10.35630/2023/13/6.609","DOIUrl":"https://doi.org/10.35630/2023/13/6.609","url":null,"abstract":"Ocular manifestations in autoimmune diseases are mainly related to the formation of a chronic inflammatory process in the body. This is caused by an error in the body's histocompatibility system, which results in the lymphocyte attacking its own cells, which the lymphocyte considers foreign. Various autoimmune diseases with ocular symptoms may have different inflammation-related pathophysiology, ranging from increased vascular permeability in diabetic retinopathy to lymphocytic pressure in the exocrine glands in Sjögren's syndrome. The inflammatory process in the eye tissues leads to symptoms such as pain, redness, photosensitivity, tearing and reduced visual acuity. One of the most common autoimmune diseases associated with ocular symptoms is systemic lupus erythematosus, in which 50% of patients experience ocular symptoms. Ocular manifestations may worsen or improve depending on disease activity. Ophthalmological examination is extremely important for patients with autoimmune diseases because it allows for the early detection and treatment of eye-related diseases, monitoring the side effects of medications taken, and identifying other related health problems.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"48 6","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karolina Borowska-Waniak, Maja Borowska, Dominik Michalik, Anita Marcinkiewicz, Aleksandra Ochotnicka
Cancers during pregnancy are a relatively rare phenomenon, but the risk of developing them increases with a woman's age. As more women choose to become pregnant at an older age, the incidence of cases may rise in the future. This article discusses the diagnosis and treatment of the most common cancers in pregnant women: breast cancer, cervical cancer, ovarian cancer, thyroid cancer, colorectal cancer, lung cancer, lymphomas, and melanoma. The aim of this work is to present optimal methods for the treatment and diagnosis of cancers during pregnancy, as the approach for pregnant patients is limited in options. Methods: We analyzed scientific papers on the safety of diagnostics and treatment of breast cancer, cervical cancer, ovarian cancer, thyroid cancer, colorectal cancer, lung cancer, lymphomas, and melanoma. We used PubMed, Google Scholar, and specialized literature to search for information. Conclusions: Due to the limited options for treatment and diagnosis in pregnant women, each case of illness should be considered individually, with an assessment of potential risks and benefits for both the mother and the child. Increased oncological vigilance should be maintained in pregnant women since some pregnancy symptoms often overlap with the initial symptoms of cancer.
{"title":"CANCER DURING PREGNANCY AND POSSIBLE TREATMENT OPTIONS - LITERATURE REVIEW","authors":"Karolina Borowska-Waniak, Maja Borowska, Dominik Michalik, Anita Marcinkiewicz, Aleksandra Ochotnicka","doi":"10.35630/2023/13/6.607","DOIUrl":"https://doi.org/10.35630/2023/13/6.607","url":null,"abstract":"Cancers during pregnancy are a relatively rare phenomenon, but the risk of developing them increases with a woman's age. As more women choose to become pregnant at an older age, the incidence of cases may rise in the future. This article discusses the diagnosis and treatment of the most common cancers in pregnant women: breast cancer, cervical cancer, ovarian cancer, thyroid cancer, colorectal cancer, lung cancer, lymphomas, and melanoma. The aim of this work is to present optimal methods for the treatment and diagnosis of cancers during pregnancy, as the approach for pregnant patients is limited in options. Methods: We analyzed scientific papers on the safety of diagnostics and treatment of breast cancer, cervical cancer, ovarian cancer, thyroid cancer, colorectal cancer, lung cancer, lymphomas, and melanoma. We used PubMed, Google Scholar, and specialized literature to search for information. Conclusions: Due to the limited options for treatment and diagnosis in pregnant women, each case of illness should be considered individually, with an assessment of potential risks and benefits for both the mother and the child. Increased oncological vigilance should be maintained in pregnant women since some pregnancy symptoms often overlap with the initial symptoms of cancer.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"172 2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric and adolescent scoliosis is one of the most common and prevailing orthopedic pathologies leading to spinal deformation. Cases of scoliosis where curving of the spine is <45% treated mostly surgically. However, when the spine is straightened with an implant, there are risks and complications. Hence, interest to conservative treatment methods has increased significantly. This article discusses advantages and disadvantages of non-invasive methods for treating scoliosis. The disadvantage is the duration of treatment: treating scoliosis using conservative methods such as physical therapy and wearing bondages can take a long time to achieve results. Also, there is a need for regular control: conservative treatment of scoliosis requires regular control by doctors and specialists to assess progress and change treatment plan if necessary. The most promising methods of conservative treatment, including correction of the muscular system, have been identified – adaptation physical exercises and gymnastics due to physical impact on kyphotic and scoliotic deformity. This includes breathing and physical exercises, therapeutic horse riding and wearing rigid torsion brace.
{"title":"A COMPARATIVE REVIEW OF NON-INVASIVE SCOLIOSIS TREATMENT IN CHILDREN AND TEENAGERS","authors":"Iskander Kasimov, Ivan Oshchepkov","doi":"10.35630/2023/13/6.608","DOIUrl":"https://doi.org/10.35630/2023/13/6.608","url":null,"abstract":"Pediatric and adolescent scoliosis is one of the most common and prevailing orthopedic pathologies leading to spinal deformation. Cases of scoliosis where curving of the spine is <45% treated mostly surgically. However, when the spine is straightened with an implant, there are risks and complications. Hence, interest to conservative treatment methods has increased significantly. This article discusses advantages and disadvantages of non-invasive methods for treating scoliosis. The disadvantage is the duration of treatment: treating scoliosis using conservative methods such as physical therapy and wearing bondages can take a long time to achieve results. Also, there is a need for regular control: conservative treatment of scoliosis requires regular control by doctors and specialists to assess progress and change treatment plan if necessary. The most promising methods of conservative treatment, including correction of the muscular system, have been identified – adaptation physical exercises and gymnastics due to physical impact on kyphotic and scoliotic deformity. This includes breathing and physical exercises, therapeutic horse riding and wearing rigid torsion brace.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"171 S1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Puchkina, Nadezhda Bondarenko, Vyacheslav Mikhaylichenko, DMITRY PARSHIN, A. Sulima, Zoya Rumyantseva, Svetlana Murunova
Purpose of the Study: To analyze the effectiveness of using sodium deoxyribonucleate (SDN) for pelvic adhesions in rats in experiment. Materials and Methods: The experiment was carried out on 90 laboratory rats. Three groups of 30 animals each were formed: group 1 – control; group 2 – rats with a simulated adhesive process in the pelvis without subsequent treatment; group 3 – animals with a model of adhesive process in the pelvis receiving intramuscular SDN for 10 days. The adhesive process in the pelvis was modeled in rats by ligating the uterine horns on both sides. The expression of CD4, CD8, CD20, CD138 was studied using DP-SOFT software program and subsequent statistical processing. Results: In animals of the control group, a small number of cells with expression of CD4+, CD8+ and CD138 markers were found in the parietal peritoneum (PP). In perimetrium (PM), no positively stained cells of the studied immunophenotype were found. In group 2, animals showed an increase in the number of cells in the PP positively expressing CD4+ and CD138+, and the appearance of CD56+ cells. An increase in the number of CD138+ and CD4+ cells was found in the rats’ PM. In group 3, compared to the control, the count of CD4+ cells, CD56+ cells and CD138+ cells significantly increased. In the PM of the operated animals, we found an increase in the number of cells positively expressing CD4+ and CD138+, and the appearance of CD56+ cells. In the PM of rats, an increase in the number of CD138+ and CD4+ cells was noted, which indicates activation of the humoral immune system. In group 3, the count of CD4+, CD56+ and CD138+ – cells in the PP significantly increased compared to the control. PM was characterized by a similar distribution of cells. Conclusion: After surgery, the adhesive process causes a change in the ratio of leukocyte subpopulations in the affected area towards an increase in their number in the parietal peritoneum rather than in the perimetrium. The use of SDN has an immunomodulatory effect and stimulates immune responses by increasing the number of immunocompetent cells in the surgical site.
{"title":"EFFECTIVENESS OF IMMUNOSTIMULATION FOR POSTOPERATIVE INTRA-ABDOMINARY ADHESION IN AN EXPERIMENTAL RAT MODEL","authors":"G. Puchkina, Nadezhda Bondarenko, Vyacheslav Mikhaylichenko, DMITRY PARSHIN, A. Sulima, Zoya Rumyantseva, Svetlana Murunova","doi":"10.35630/2023/13/6.602","DOIUrl":"https://doi.org/10.35630/2023/13/6.602","url":null,"abstract":"Purpose of the Study: To analyze the effectiveness of using sodium deoxyribonucleate (SDN) for pelvic adhesions in rats in experiment. Materials and Methods: The experiment was carried out on 90 laboratory rats. Three groups of 30 animals each were formed: group 1 – control; group 2 – rats with a simulated adhesive process in the pelvis without subsequent treatment; group 3 – animals with a model of adhesive process in the pelvis receiving intramuscular SDN for 10 days. The adhesive process in the pelvis was modeled in rats by ligating the uterine horns on both sides. The expression of CD4, CD8, CD20, CD138 was studied using DP-SOFT software program and subsequent statistical processing. Results: In animals of the control group, a small number of cells with expression of CD4+, CD8+ and CD138 markers were found in the parietal peritoneum (PP). In perimetrium (PM), no positively stained cells of the studied immunophenotype were found. In group 2, animals showed an increase in the number of cells in the PP positively expressing CD4+ and CD138+, and the appearance of CD56+ cells. An increase in the number of CD138+ and CD4+ cells was found in the rats’ PM. In group 3, compared to the control, the count of CD4+ cells, CD56+ cells and CD138+ cells significantly increased. In the PM of the operated animals, we found an increase in the number of cells positively expressing CD4+ and CD138+, and the appearance of CD56+ cells. In the PM of rats, an increase in the number of CD138+ and CD4+ cells was noted, which indicates activation of the humoral immune system. In group 3, the count of CD4+, CD56+ and CD138+ – cells in the PP significantly increased compared to the control. PM was characterized by a similar distribution of cells. Conclusion: After surgery, the adhesive process causes a change in the ratio of leukocyte subpopulations in the affected area towards an increase in their number in the parietal peritoneum rather than in the perimetrium. The use of SDN has an immunomodulatory effect and stimulates immune responses by increasing the number of immunocompetent cells in the surgical site.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"100 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vyacheslav Mykhaylichenko, Magomed Ahmadov, DMITRY PARSHIN, A. Butyrskii, Enver Kеrimov
The authors presented a clinical case of left subclavian steal syndrome in a 62-year-old man. The main complaints were dizziness, tinnitus, memory loss and unsteady gait. The patient had severe concomitant pathology: coronary heart disease, hypertension, heart failure. X-ray endovascular technologies (balloon dilatation and stenting) made it possible to completely restore blood flow in the affected segment. After treatment, the above complaints disappeared. Minimally invasive X-ray endovascular techniques have particular benefits in patients with severe comorbid pathology.
作者介绍了一例 62 岁男性左锁骨下动脉盗血综合征的临床病例。患者主要表现为头晕、耳鸣、记忆力减退和步态不稳。患者伴有严重的并发症：冠心病、高血压、心力衰竭。X 射线血管内技术（球囊扩张术和支架植入术）使受影响区段的血流得以完全恢复。治疗后，上述不适症状消失了。微创 X 射线血管内技术对合并严重病症的患者特别有益。
{"title":"ENDOVASCULAR TREATMENT OF SUBCLAVIAN STEAL SYNDROME: A CLINICAL CASE","authors":"Vyacheslav Mykhaylichenko, Magomed Ahmadov, DMITRY PARSHIN, A. Butyrskii, Enver Kеrimov","doi":"10.35630/2023/13/6.606","DOIUrl":"https://doi.org/10.35630/2023/13/6.606","url":null,"abstract":"The authors presented a clinical case of left subclavian steal syndrome in a 62-year-old man. The main complaints were dizziness, tinnitus, memory loss and unsteady gait. The patient had severe concomitant pathology: coronary heart disease, hypertension, heart failure. X-ray endovascular technologies (balloon dilatation and stenting) made it possible to completely restore blood flow in the affected segment. After treatment, the above complaints disappeared. Minimally invasive X-ray endovascular techniques have particular benefits in patients with severe comorbid pathology.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"126 18","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Serik Abdreshov, U. Kozhaniyazova, Natalia Bgatova, Georgy Demchenko, S. Shynybekova, Berikzhan Oxikbayev
Lymph nodes play an important role in the life of humans and animals. In the modern concept, the lymph nodes are the main homeostatic organs of the internal environment of the body, the lymph nodes are part of the lymphatic bed, on the other hand, they are the organs of the lymphoid (immune) system. Purpose: The work presents data on the morphofunctional state and microstructure of regional lymph nodes in experimental hypothyroidism and under correction. Materials and Methods: Experimental hypothyroidism in animals was induced by per os administration of mercazolil at a dose of 20 mg per 100 g of body weight with drinking water for 21 days. To correct thyroid disorders, starting from the 22nd day of the experiment, the animals received for 30 days an iodine-containing dietary supplement "Renaissance Plus" balm in powder at the rate of 2 μg/100 g of body weight and a decoction of the roots of the white cinquefoil (Potentilla alba L.) 50 ml per 100 g per day with drinking water. Results: The results of the study showed that in conditions of hypothyroidism, the lymph node becomes compacted with a decrease in the main structural and functional zones against the background of reduced lymphopoietic function. In the lymphoid nodule, there is a decrease of 1.43 times in the number of lymphoblasts, 1.56 times in the number of medium lymphocytes, 1.50 times in the number of small lymphocytes due to an increase of 1.29 times in the number of macrophages per unit area of the lymphoid nodule in the lymph node. There was a static decrease in the number of small lymphocytes in all structural and functional areas; the number of blasts decreases in the lymphoid nodule and increases in the paracortex and Billroth's strand; the number of macrophages increases in the lymphoid nodule, cerebral sinus, the number of mature plasma cells decreases in the paracortex and Billroth's strand, and there is also inhibition of cellular reactions in the lymph node, which reflects a decrease in the lymphopoietic function of immune activity and as a result of the immunosuppressive action of mercazolil. Conclusions: After an administration of corrigents, the area of the medulla and paracortex was restored to the control level and the ratio of cortical and medulla in the overall structure of the lymph node was leveled.
淋巴结在人类和动物的生命中扮演着重要角色。在现代概念中，淋巴结是机体内环境的主要平衡器官，淋巴结是淋巴床的一部分，另一方面，淋巴结也是淋巴（免疫）系统的器官。目的：本研究介绍了实验性甲状腺功能减退症和矫正过程中区域淋巴结的形态功能状态和微观结构。材料与方法以每100克体重20毫克的剂量，通过饮水诱导动物实验性甲状腺机能减退，连续21天。为了纠正甲状腺功能紊乱，从实验的第 22 天开始，连续 30 天以每 100 克体重 2 μg 的剂量给动物服用含碘的食物补充剂 "Renaissance Plus "香膏粉末，以及以每 100 克体重 50 毫升的剂量将白花蛇舌草（Potentilla alba L.）根部煎煮后与饮用水一起服用。研究结果研究结果表明，在甲状腺机能减退的情况下，淋巴结会变小，主要结构和功能区减少，淋巴造血功能降低。在淋巴结中，淋巴母细胞数量减少了1.43倍，中淋巴细胞数量减少了1.56倍，小淋巴细胞数量减少了1.50倍，而淋巴结中淋巴结单位面积的巨噬细胞数量增加了1.29倍。所有结构和功能区的小淋巴细胞数量都在静态减少；淋巴结中的胚泡数量减少，而副皮质和比洛斯股中的胚泡数量增加；淋巴结、脑窦的巨噬细胞数量增加，皮质旁和比洛斯股的成熟浆细胞数量减少，淋巴结的细胞反应也受到抑制，这反映了免疫活动的淋巴造血功能下降，是巯基乙酸免疫抑制作用的结果。结论服用可瑞吉后，髓质和皮质旁的面积恢复到了对照组的水平，淋巴结整体结构中皮质和髓质的比例也趋于平衡。
{"title":"MORPHOFUNCTIONAL STATE AND MICROSTRUCTURE OF REGIONAL LYMPH NODES IN EXPERIMENTAL HYPOTHYROIDISM AND UNDER CORRECTION","authors":"Serik Abdreshov, U. Kozhaniyazova, Natalia Bgatova, Georgy Demchenko, S. Shynybekova, Berikzhan Oxikbayev","doi":"10.35630/2023/13/6.601","DOIUrl":"https://doi.org/10.35630/2023/13/6.601","url":null,"abstract":"Lymph nodes play an important role in the life of humans and animals. In the modern concept, the lymph nodes are the main homeostatic organs of the internal environment of the body, the lymph nodes are part of the lymphatic bed, on the other hand, they are the organs of the lymphoid (immune) system. Purpose: The work presents data on the morphofunctional state and microstructure of regional lymph nodes in experimental hypothyroidism and under correction. Materials and Methods: Experimental hypothyroidism in animals was induced by per os administration of mercazolil at a dose of 20 mg per 100 g of body weight with drinking water for 21 days. To correct thyroid disorders, starting from the 22nd day of the experiment, the animals received for 30 days an iodine-containing dietary supplement \"Renaissance Plus\" balm in powder at the rate of 2 μg/100 g of body weight and a decoction of the roots of the white cinquefoil (Potentilla alba L.) 50 ml per 100 g per day with drinking water. Results: The results of the study showed that in conditions of hypothyroidism, the lymph node becomes compacted with a decrease in the main structural and functional zones against the background of reduced lymphopoietic function. In the lymphoid nodule, there is a decrease of 1.43 times in the number of lymphoblasts, 1.56 times in the number of medium lymphocytes, 1.50 times in the number of small lymphocytes due to an increase of 1.29 times in the number of macrophages per unit area of the lymphoid nodule in the lymph node. There was a static decrease in the number of small lymphocytes in all structural and functional areas; the number of blasts decreases in the lymphoid nodule and increases in the paracortex and Billroth's strand; the number of macrophages increases in the lymphoid nodule, cerebral sinus, the number of mature plasma cells decreases in the paracortex and Billroth's strand, and there is also inhibition of cellular reactions in the lymph node, which reflects a decrease in the lymphopoietic function of immune activity and as a result of the immunosuppressive action of mercazolil. Conclusions: After an administration of corrigents, the area of the medulla and paracortex was restored to the control level and the ratio of cortical and medulla in the overall structure of the lymph node was leveled.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"174 4","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vyacheslav Mykhaylichenko, Alexander Tsaturyan, DMITRY PARSHIN, Seyfeddine Khizriev, Andrey Pilipchuk
Purpose of the Study: In this article, the team of authors shares their own experience of performing the procedure of therapeutic angiogenesis with plasmid DNA in the department of surgery. Materials and Methods: From November 2020 to December 2021, the department performed 64 procedures of therapeutic angiogenesis using plasmid DNA in 32 patients with distal steno-occlusive lesions of lower limb arteries, with CAI II-A - CAI III according to Pokrovsky-Fontaine. All patients included in the statistics of this work were questionnaired (SF-36) and thoroughly interviewed during the writing of this article. Results: Of the 32 patients, only two (6.25%) noted a deterioration in their condition, of which one patient with CAI III and diabetes underwent hip amputation after 1.5 months. In the second patient, three months after the repeated procedure of therapeutic angiogenesis, the distance of pain-free walking decreased from 350 to 250 meters, which can be associated with severe nicotine addiction and inability to quit smoking. Four patients did not note any significant changes in their condition in the period from 2.5 to 6 months after repeated administration of the drug. 12 patients (37.5%) noted moderate positive changes in the form of an increase in pain-free walking distance, a decrease in pain, and an improvement in quality of life. 14 patients (43.75%) claimed a significant increase in pain-free walking distance and assessed the results of the therapy as good. The greatest positive dynamics were observed in the groups CAI II-A and CAI II-B. The peak of positive dynamics of pain-free walking distance was noted 3-6 months after the second administration of the drug. Conclusion: As a result of treatment with plasmid DNA, we noted a significant positive effect from the procedure, especially in patients with intermittent claudication. In a group of patients with critical ischemia, the procedure of therapeutic angiogenesis became the only means to preserve the limb.
研究目的：在本文中，作者团队分享了他们在外科使用质粒 DNA 进行治疗性血管生成的经验。材料与方法：2020 年 11 月至 2021 年 12 月，该科室为 32 名下肢动脉远端狭窄闭塞病变患者实施了 64 例使用质粒 DNA 的治疗性血管生成手术，根据 Pokrovsky-Fontaine 标准，这些患者的 CAI 为 II-A - CAI III。在撰写本文期间，对所有纳入统计的患者进行了问卷调查（SF-36）和详细访谈。结果：在 32 名患者中，只有两名患者（6.25%）的病情出现恶化，其中一名患有 CAI III 和糖尿病的患者在 1.5 个月后接受了髋关节截肢手术。第二名患者在重复治疗性血管生成手术三个月后，无痛行走距离从 350 米减少到 250 米，这可能与严重的尼古丁成瘾和无法戒烟有关。有 4 名患者在反复用药 2.5 至 6 个月期间病情没有发生明显变化。12名患者（37.5%）指出病情有中度积极变化，表现为无痛行走距离增加、疼痛减轻和生活质量改善。14名患者（43.75%）声称无痛行走距离明显增加，并将治疗效果评定为良好。在 CAI II-A 组和 CAI II-B 组观察到了最大的积极动态。在第二次用药 3-6 个月后，无痛行走距离的积极动态达到顶峰。结论使用DNA质粒进行治疗后，我们发现该疗法具有显著的积极效果，尤其是对间歇性跛行患者。在一组严重缺血的患者中，治疗性血管生成程序成为保存肢体的唯一方法。
{"title":"EXPERIENCE IN THE USE OF THERAPEUTIC ANGIOGENESIS WITH PLASMID DEOXYRIBONUCLEIC ACID IN PATIENTS WITH NON-SHUNTABLE LESIONS OF LOWER LIMB ARTERIES","authors":"Vyacheslav Mykhaylichenko, Alexander Tsaturyan, DMITRY PARSHIN, Seyfeddine Khizriev, Andrey Pilipchuk","doi":"10.35630/2023/13/6.605","DOIUrl":"https://doi.org/10.35630/2023/13/6.605","url":null,"abstract":"Purpose of the Study: In this article, the team of authors shares their own experience of performing the procedure of therapeutic angiogenesis with plasmid DNA in the department of surgery. Materials and Methods: From November 2020 to December 2021, the department performed 64 procedures of therapeutic angiogenesis using plasmid DNA in 32 patients with distal steno-occlusive lesions of lower limb arteries, with CAI II-A - CAI III according to Pokrovsky-Fontaine. All patients included in the statistics of this work were questionnaired (SF-36) and thoroughly interviewed during the writing of this article. Results: Of the 32 patients, only two (6.25%) noted a deterioration in their condition, of which one patient with CAI III and diabetes underwent hip amputation after 1.5 months. In the second patient, three months after the repeated procedure of therapeutic angiogenesis, the distance of pain-free walking decreased from 350 to 250 meters, which can be associated with severe nicotine addiction and inability to quit smoking. Four patients did not note any significant changes in their condition in the period from 2.5 to 6 months after repeated administration of the drug. 12 patients (37.5%) noted moderate positive changes in the form of an increase in pain-free walking distance, a decrease in pain, and an improvement in quality of life. 14 patients (43.75%) claimed a significant increase in pain-free walking distance and assessed the results of the therapy as good. The greatest positive dynamics were observed in the groups CAI II-A and CAI II-B. The peak of positive dynamics of pain-free walking distance was noted 3-6 months after the second administration of the drug. Conclusion: As a result of treatment with plasmid DNA, we noted a significant positive effect from the procedure, especially in patients with intermittent claudication. In a group of patients with critical ischemia, the procedure of therapeutic angiogenesis became the only means to preserve the limb.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"3 2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vladimir Murga, Leonid Rasskazov, V. Krestyashin, N. Marasanov
The article presents almost forty years of experience in the treatment and follow-up of congenital hip dislocation in 839 children at Tver Children's Regional Clinical Hospital (Russia). An analysis of conservative and surgical treatment methods was carried out taking into account concomitant pathology. The children were aged from 3 months to 13 years, girls predominated (78%). Bilateral damage to the hip joints was observed in 278 children (33%), unilateral - in 561 children (67%). Surgical treatment was performed in 312 patients (37.2%).The majority of patients admitted with a diagnosis of congenital hip dislocation were treated conservatively (527 - 62.8%). Long-term results of treatment (12-27 years from the start of treatment) were monitored in 174 patients. 123 of them (70.7%) obtained good anatomical and functional treatment results (no complaints or functional limitations, anatomically correct formation of the hip joints according to radiation diagnostics), 45 (25.8%) - the treatment results were assessed by us as satisfactory (patients considered themselves healthy, but X-rays revealed subluxation of the femoral head without degenerative-dystrophic changes). In 6 surgically treated patients (3.4%), deforming coxarthrosis occurred, which required endoprosthetics at the age of 27-33 years. Dysplastic changes in the musculoskeletal system require an integrated approach involving specialists of various profiles at all stages of the child’s treatment.
{"title":"AN INTEGRATED APPROACH TO THE TREATMENT OF CONGENITAL HIP DISLOCATION","authors":"Vladimir Murga, Leonid Rasskazov, V. Krestyashin, N. Marasanov","doi":"10.35630/2023/13/6.603","DOIUrl":"https://doi.org/10.35630/2023/13/6.603","url":null,"abstract":"The article presents almost forty years of experience in the treatment and follow-up of congenital hip dislocation in 839 children at Tver Children's Regional Clinical Hospital (Russia). An analysis of conservative and surgical treatment methods was carried out taking into account concomitant pathology. The children were aged from 3 months to 13 years, girls predominated (78%). Bilateral damage to the hip joints was observed in 278 children (33%), unilateral - in 561 children (67%). Surgical treatment was performed in 312 patients (37.2%).The majority of patients admitted with a diagnosis of congenital hip dislocation were treated conservatively (527 - 62.8%). Long-term results of treatment (12-27 years from the start of treatment) were monitored in 174 patients. 123 of them (70.7%) obtained good anatomical and functional treatment results (no complaints or functional limitations, anatomically correct formation of the hip joints according to radiation diagnostics), 45 (25.8%) - the treatment results were assessed by us as satisfactory (patients considered themselves healthy, but X-rays revealed subluxation of the femoral head without degenerative-dystrophic changes). In 6 surgically treated patients (3.4%), deforming coxarthrosis occurred, which required endoprosthetics at the age of 27-33 years. Dysplastic changes in the musculoskeletal system require an integrated approach involving specialists of various profiles at all stages of the child’s treatment.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"17 68","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anita Marcinkiewicz, Aleksandra Ochotnicka, Karolina Borowska-Waniak, Kinga Skorupińska, Dominik Michalik, Maja Borowska
Combustion of fossil fuels, industrial emissions, biomass and waste combustion results in an increase in the amount of harmful substances such as sulfur dioxides, nitrogen oxides, carbon monoxide, ozone, particulate matter or aromatic hydrocarbons in the environment. The air full of pollutants that we all breathe affects our respiratory and cardiovascular systems and is also a factor leading to the development of cancer. The polluted air we breathe in every day drives the influx macrophages that release inflammatory mediators such as interleukin-1β, accelerating the expansion of cells with EGFR mutations. Overexpression mutated EGFR gene is characteristic of non-small cell lung cancer. Adenocarcinoma is one of the most common lung cancers. It accounts for 40% of all types of lung cancer. In the European Union, Bulgaria and Poland are among the most polluted countries, while Sofia, Nicosia and Warsaw are the three most polluted capitals. Solid particles suspended in the air have been recognized by the International Agency for Research on Cancer (IARC) as a factor group I carcinogen. The concentration of PM10 measured at regional background stations, i.e. outside the direct impact of traffic pollution and outside city centers, in Poland is almost the highest in Europe and amounts to over 60 µg/m3 with the standard up to 20 µg/m3. An adult person inhales 10-12 m3 of air per day, and with it inhales the pollutants contained in it into the body. The aim of our work was to examine the correlation between air pollution and lung cancer and to conclude that anyone may be at risk.
{"title":"THE IMPACT OF AIR POLLUTION ON THE OCCURRENCE OF LUNG CANCER: A LITERATURE REVIEW","authors":"Anita Marcinkiewicz, Aleksandra Ochotnicka, Karolina Borowska-Waniak, Kinga Skorupińska, Dominik Michalik, Maja Borowska","doi":"10.35630/2023/13/5.507","DOIUrl":"https://doi.org/10.35630/2023/13/5.507","url":null,"abstract":"Combustion of fossil fuels, industrial emissions, biomass and waste combustion results in an increase in the amount of harmful substances such as sulfur dioxides, nitrogen oxides, carbon monoxide, ozone, particulate matter or aromatic hydrocarbons in the environment. The air full of pollutants that we all breathe affects our respiratory and cardiovascular systems and is also a factor leading to the development of cancer. The polluted air we breathe in every day drives the influx macrophages that release inflammatory mediators such as interleukin-1β, accelerating the expansion of cells with EGFR mutations. Overexpression mutated EGFR gene is characteristic of non-small cell lung cancer. Adenocarcinoma is one of the most common lung cancers. It accounts for 40% of all types of lung cancer. In the European Union, Bulgaria and Poland are among the most polluted countries, while Sofia, Nicosia and Warsaw are the three most polluted capitals. Solid particles suspended in the air have been recognized by the International Agency for Research on Cancer (IARC) as a factor group I carcinogen. The concentration of PM10 measured at regional background stations, i.e. outside the direct impact of traffic pollution and outside city centers, in Poland is almost the highest in Europe and amounts to over 60 µg/m3 with the standard up to 20 µg/m3. An adult person inhales 10-12 m3 of air per day, and with it inhales the pollutants contained in it into the body. The aim of our work was to examine the correlation between air pollution and lung cancer and to conclude that anyone may be at risk.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136312568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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