姜黄素和抗坏血酸泡腾剂的全因子设计融合工艺配方、优化及评价

Q4 Pharmacology, Toxicology and Pharmaceutics Journal of Natural Remedies Pub Date : 2023-10-27 DOI:10.18311/jnr/2023/33927
Manisha Jadav, None Vikas Pal, Himanshi Pandit, Nikhil Suthar, Anand Pithadia, Lalit Lata Jha
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引用次数: 0

摘要

最近的研究表明,姜黄素与抗坏血酸结合具有强大的免疫活性。因此,研究了姜黄素和抗坏血酸起泡颗粒作为COVID-19的预防措施。采用Stat-Ease Design-Expert v7.0.0软件,采用融合法,应用32个全因子设计,得到13个公式(F1 ~ F13)。为了提高姜黄素的溶解度,采用冻干法制备了羟丙基-环糊精与姜黄素的配合物。用柠檬酸、酒石酸、碳酸氢钠、聚乙二醇和山梨醇配制泡腾状颗粒。对13种配方进行相容性、流动性、泡沫化时间等评价研究。结果表明,该颗粒具有良好的流动性能,具有合适的堆积密度和抽头密度。FTIR研究也表明辅料之间没有相互作用。所有批次的起泡时间均小于3分钟。公式4给出了最佳的泡沫化效果。这篇研究文章涵盖了含有姜黄素的泡腾状颗粒的发展,姜黄素具有抗病毒特性(通过对病毒的直接运动和调节免疫系统)。在我们面临冠状病毒大流行的情况下,姜黄素和抗坏血酸可以通过保持我们的免疫力和抵御感染的冲击,为我们提供预防COVID-19的保护。
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Formulation, Optimization and Evaluation of Nutraceutical Effervescent Granules Containing Curcumin and Ascorbic Acid by Fusion Technique Using Full Factorial Design
Recent studies suggest that curcumin has potent immunological activity in combination with ascorbic acid. Hence, research was carried out to formulate effervescent granules of curcumin and ascorbic acid as preventive measures for COVID-19. Thirteen formulas (F1 to F13) were prepared by applying 32 full factorial designs by applying the fusion method using Stat-Ease Design-Expert v7.0.0 software. Here, a complex of hydroxypropyl beta-cyclodextrin and curcumin was prepared by lyophilization technique to improve the solubility of curcumin. Citric acid, tartaric acid, sodium bicarbonate, polyethylene glycol, and sorbitol were used in the formulation of effervescent granules. Evaluation studies were carried out for all 13 formulas, including compatibility study, flowability study and effervescence time. The results show that granules have excellent flow property with an appropriate bulk density and tapped density for the uniting dose. The FTIR study also indicates that there is no interaction between excipients. The effervescence time is less than 3 minutes for all the batches. Formula 4 shows the best effervescence. This research article covers the development of effervescent granules containing curcumin, which has antiviral properties (both through direct movement on viruses and through modulating the immune system). With the pandemic of coronavirus that we are facing, curcumin and ascorbic acid can provide us protection against COVID-19 by keeping our immunity up and protecting against the onslaught of infections.
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来源期刊
Journal of Natural Remedies
Journal of Natural Remedies Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
27
期刊介绍: Nature can provide all the remedies, for all. All substances produced by nature can be recognized; all cells talk the same language as we all are from the same mother cell. Journal of Natural Remedies is devoted toward the understandings of all remedies from nature. Journal of Natural Remedies publishes original articles related to utilisation of any natural source for remedy including bioactive natural products. Studies related to the resources, chemistry (including analytical), biological activity, biotechnology and pharmacology (including toxicology) of archaea, bacteria, protistas, fungi, plants, animals, viruses and minerals fall within the journal’s scope.
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