兽用制剂“曲明加”脂肪酸、极性和非极性挥发性有机物的测定

IF 0.2 Q4 CHEMISTRY, MULTIDISCIPLINARY Izvestiya Vuzov-Prikladnaya Khimiya i Biotekhnologiya Pub Date : 2023-09-30 DOI:10.21285/2227-2925-2023-13-3-382-391
V. A. Chkhenkeli, G. D. Chkhenkeli, A. A. Nikonova, A. G. Gorshkov
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引用次数: 0

摘要

为了预防和治疗生长猪相关的胃肠道和呼吸道疾病,提出了一种新的兽用制剂“曲美丁+”。该药物是利用生物技术方法从木营养真菌中获得的。这类制剂的性质取决于其组合物中所含的生物活性物质。现有的出版物提供了关于木材破坏真菌合成的脂肪形成特征和脂肪酸组成的各种信息。本研究对脂肪酸的定性和定量组成进行了研究,并对“tramtin Plus”的挥发性极性和非极性有机化合物进行了分析。脂肪酸的总浓度为70µg/g,其中50.0%为游离酸,50.0%为脂肪酸酯。角鲨烯是最主要的非极性挥发性成分。至于“tramtin Plus”的少量非极性挥发性成分,这些是低分子量的氨基酸,如甘氨酸、精氨酸和β-丙氨酸。分析证实了该制剂的多组分组成,这说明了其多种生物学特性,即抗菌、抗病毒、抗氧化和增强免疫活性。这些特性决定了所研究的兽药制剂具有较高的健康促进功效。
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Determining the fatty acids, polar and non-polar volatile organic compounds of the veterinary preparation “Trametin Plus”
For the prevention and treatment of associated gastrointestinal and respiratory diseases of growing stock, a new veterinary preparation “Trametin Plus” is proposed. This drug is obtained from fungi-xylotrophs using biotechnology methods. The properties of such preparations depend on bioactive substances included in their composition. Available publications present miscellaneous information on the lipogenesis features and fatty acids composition synthesized by wood-destroying fungi. In this work, we study the qualitative and quantitative composition of fatty acids and analyze volatile polar and non-polar organic compounds of “Trametin Plus”. The total concentration of fatty acids was found to be 70 µg/g, with 50.0% being free acids and 50.0% being their esters. Squalene was established to be the most dominant non-polar volatile component. Concerning the minor non-polar volatile components of “Trametin Plus”, these are amino acids with a low molecular weight, such as glycine, arginine and β-alanine. The analysis confirms the multicomponent composition of the preparation, which accounts for its diverse biological properties, namely antibacterial, antiviral, antioxidant and immune-boosting activity. These properties determine the high health-promoting efficacy of the studied veterinary preparation.
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50.00%
发文量
63
审稿时长
12 weeks
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