[应用单克隆抗体诊断动物狂犬病]。

O Akacem, A Taril, A Benelmouffok, A Bemansour, P Couillin, M Brahimi, M Benhassine
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引用次数: 0

摘要

两种病毒核衣壳特异性单克隆抗体(M.A. D-20和M.A. D-43)针对一种固定的狂犬病毒株(C.V.S. 11)而产生,并与标准抗狂犬血清(S.A.R.)平行进行了诊断动物狂犬病毒感染的试验。用单克隆抗体间接免疫荧光技术对44例狂犬病死亡动物脑印迹进行了检测。在所有研究的动物狂犬病毒感染的诊断中,m.a.d -43与S.A.R.之间存在持续的相关性。对于ma - D-20,仅在有限的病例中发现与S.A.R.结果一致。
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[Diagnosis of rabies infection in animals using monoclonal antibodies].

Two monoclonal antibodies (M.A.), specific for viral nucleocapsid, the M.A. D-20 and the M.A. D-43 raised against a fixed strain of rabies virus (C.V.S. 11), have been tested in parallel with a standard antirabies serum (S.A.R.) in diagnosis of animal rabies virus infection. 44 brain imprints from animals which died from rabies were tested by indirect immunofluorescent technique with monoclonal antibodies. Constant correlation has been found between the M.A. D-43 and the S.A.R. in the diagnosis of animal rabies virus infection in all cases studied. For M.A. D-20, concordance of results with S.A.R. was found only in limited number of cases.

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