自然发生的全身性炎症的嗅觉提示:季节性过敏的初步研究。

IF 2.2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2023-01-01 Epub Date: 2023-11-16 DOI:10.1159/000535047
Arnaud Tognetti, Supreet Saluja, Nathalie Lybert, Julie Lasselin, Sandra Tamm, Catarina Lensmar, Bianka Karshikoff, Simon Cervenka, Mats Lekander, Mats J Olsson
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引用次数: 0

摘要

导言:为了避免与传染性个体接触,人类可能会对一般的而不是特定的疾病标志物作出反应。因此,如果一个没有传染性的人看起来(例如,面部变色)、动作(例如,走路速度较慢)或声音(例如,打喷嚏)不舒服,人们可能会认为他在社交上不那么有吸引力。这项初步研究测试了人类是否厌恶患有低度全身性炎症的非传染性个体的体味。方法:采集严重季节性变态反应患者(14例)和健康对照(10例)在变态反应季节和季节外的腋窝体味,测定两种炎症因子(肿瘤坏死因子-α、白细胞介素-5)的血清水平。然后,独立参与者(N = 67)对这些气味进行取样,并根据强度和愉悦度对其进行评级。结果:虽然与非过敏季节和健康对照相比,季节性过敏患者在过敏季节有更多令人不快和强烈的体臭,但这些影响并不显著。当检查免疫标记物时,个体体味感知愉悦度的变化(从花粉季节到花粉季节)与白细胞介素-5水平的变化显著相关,但与肿瘤坏死因子-α无关。讨论:我们的研究结果初步表明,人类嗅觉系统可能对非传染性疾病中的炎症敏感。为了确定嗅觉在感知传染性和非传染性(如慢性病)疾病中的作用,需要进行更大规模的重复实验。
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Olfactory Cues of Naturally Occurring Systemic Inflammation: A Pilot Study of Seasonal Allergy.

Introduction: In an attempt to avoid contact with infectious individuals, humans likely respond to generalized rather than specific markers of disease. Humans may thus perceive a noninfectious individual as socially less attractive if they look (e.g., have facial discolouration), move (e.g., have a slower walking pace), or sound (e.g., sneeze) sick. This pilot study tested whether humans are averse to the body odour of noninfectious individuals with a low-grade systemic inflammation.

Methods: We collected the axillary body odour of individuals with severe seasonal allergy (N = 14) and healthy controls (N = 10) during and outside the allergy season and measured serum levels of two inflammatory cytokines (tumour necrosis factor-α and interleukin-5). Independent participants (N = 67) then sampled and rated these odours on intensity and pleasantness.

Results: While individuals with seasonal allergy had nominally more unpleasant and intense body odours during the allergy season, relative to outside the allergy season and to healthy controls, these effects were not significant. When examining immune markers, the change in perceived pleasantness of an individual's body odour (from out-to-inside pollen season) was significantly related to the change in their interleukin-5 levels but not to tumour necrosis factor-α.

Discussion: Our findings tentatively suggest that the human olfactory system could be sensitive to inflammation as present in a noncommunicable condition. Larger replications are required to determine the role of olfaction in the perception of infectious and noninfectious (e.g., chronic diseases) conditions.

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来源期刊
Neuroimmunomodulation
Neuroimmunomodulation 医学-免疫学
CiteScore
3.60
自引率
4.20%
发文量
35
审稿时长
>12 weeks
期刊介绍: The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.
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