墨西哥生物医学动物研究中的伦理知识、态度和实践。

Anayántzin Heredia-Antúnez, Miguela Galarde-López, Elizabetha Téllez-Ballesteros, Beatriz Vanda-Cantón
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摘要

在减轻生物医学研究中对动物的伤害方面,最被广泛接受的伦理概念被称为3r,即替换(replacement)、减少(reduction)和改进(refine)。我们研究的目的是确定墨西哥研究人员在制定动物研究方案时考虑的伦理和监管标准,以及伦理委员会成员在评估和批准这些方案时使用的标准。我们向来自不同研究机构的300人分发了一份调查问卷,并收到了179名研究人员和伦理委员会成员关于他们对基于3r的研究中使用动物的知识、态度和实践的回答。所获得的回应表明,受访者意识到3R概念,他们声称应用这些原则。然而,调查结果显示,在研究、测试和教学中,对使用替代方案的抵制(66%)。19%的研究人员报告说,他们的机构没有一个综合的机构动物护理和使用委员会(IACUC)。大约80%的受访者了解墨西哥的法规。研究人员和IACUC成员对3r的认识和应用是动物研究中的一个基本概念。这些知识有助于运用与在研究中使用动物有关的道德标准、态度和实践。
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Knowledge, Attitudes, and Practices on Ethics in Biomedical Animal Research in Mexico.

The most widely accepted ethical concept for the mitigation of harm to animals used in biomedical research is known as the 3Rs, which refer to replacement, reduction, and refinement. The aim of our study was to determine the ethical and regulatory criteria that researchers in Mexico consider when developing their animal research protocols and that members of the ethics committees use when they evaluate and approve these protocols. We circulated a survey to 300 individuals from different research institutions and received responses from 179 researchers and members of ethics committees on questions related to their knowledge, attitudes, and practices toward the use of animals in research based on the 3Rs. The responses obtained indicate that the respondents were aware of the 3R concept, and they claim to apply these principles. However, the responses revealed resistance to using alternatives for research, testing, and teaching (66%). Nineteen percent of the researchers reported that their institutions do not have an integrated Institutional Animal Care and Use Committee (IACUC). Around 80% of respondents were aware of Mexican regulations. The knowledge and application of the 3Rs by researchers and members of the IACUC is a fundamental concept in animal research. Such knowledge contributes the use of ethical standards, attitudes, and practices relevant to the use of animals in research.

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American Society of Laboratory Animal Practitioners Position Statement: Handling and Physical Restraint of Research Animals. American Society of Laboratory Animal Practitioners Position Statement: Definition of Animal Welfare. Effect of Novel High-fat Diet Feeding Methods on Food Wastage, Weight Gain, Hair Coat Grease Accumulation, and Scratching Behavior in C57BL/6NCrl Mice. Identification and Treatment of Fur Mites (Radfordia lemnina) in California Deer Mice (Peromyscus californicus) Using Selamectin. American Society of Laboratory Animal Practitioners Position Statement: Animal Care Principles.
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