斋月间歇禁食对健康超重和肥胖男性肾功能和肝功能指标的影响:一项前瞻性队列研究

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2023-11-11 DOI:10.1016/j.hnm.2023.200227
Ahmed Ismail Mohamed , Jama Mohamed , Mohamed Mussa Abdilahi , Barkhad Aden Abdek , Kalkidan Hassen Abate
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引用次数: 0

摘要

间歇性禁食(IF)因其促进健康和对抗慢性疾病的潜力而受到关注。这项研究的重点是斋月禁食对健康超重和肥胖男性的肾脏和肝脏功能指标、人体测量和饮食摄入的影响。斋月禁食是穆斯林观察到的一种IF形式。该研究涉及来自索马里兰哈尔格萨的60名参与者,平均年龄为40.01±7.99岁。结果显示斋月禁食后体重(P≤0.001)、腰围(P≤0.001)和体重指数(P≤0.001)均显著降低。尿素水平显著降低(P = 0.003),肌酐水平无显著降低,尿酸水平在正常范围内显著升高(P≤0.001)。血清谷草转氨酶(GOT)水平显著降低(P≤0.001),谷丙转氨酶(GPT)和碱性磷酸酶(ALP)水平保持稳定。膳食分析显示,总碳水化合物(P = 0.023)、蛋白质(P = 0.006)和膳食胆固醇摄入量显著降低(P≤0.001)。这些发现表明,斋月禁食对健康超重和肥胖男性的人体测量和肾-肝功能指标有积极影响。这项研究有助于扩大对间歇性禁食潜在健康益处的理解,强调了将斋月禁食作为预防代谢紊乱方法的重要性。进一步的研究应该探索长期影响、机制见解和个性化的临床应用,而公共卫生倡议可以教育个人关于安全和明智的禁食做法。
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Effect of Ramadan intermittent fasting on renal and liver function markers among healthy overweight and obese males: A prospective cohort study

Intermittent fasting (IF) has garnered attention for its potential to promote health and combat chronic diseases. This study focused on the effects of Ramadan fasting, a form of IF observed by Muslims, on renal and liver function markers, anthropometric measurements, and dietary intake in healthy overweight and obese men. The study involved 60 participants from Hargeisa, Somaliland, with an average age of 40.01 ± 7.99 years. Results revealed significant reductions in body weight (P ≤ 0.001), waist circumference (P ≤ 0.001), and body mass index (P ≤ 0.001) after Ramadan fasting. Urea levels decreased significantly (P = 0.003), and though creatinine levels showed a non-significant decrease, uric acid levels increased significantly within the normal range (P ≤ 0.001). Serum glutamate oxaloacetate transaminase (GOT) levels decreased significantly (P ≤ 0.001), while glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels remained stable. Dietary analysis indicated a significant decrease in total carbohydrates (P = 0.023), proteins (P = 0.006), and dietary cholesterol intake (P ≤ 0.001). These findings suggest that Ramadan fasting positively impacts anthropometric and renal-liver function markers in healthy overweight and obese men. The study contributes to the expanding understanding of intermittent fasting's potential health benefits, emphasizing the importance of considering Ramadan fasting as a preventive approach for metabolic disorders. Further research should explore long-term effects, mechanistic insights, and personalized clinical applications, while public health initiatives could educate individuals about safe and informed fasting practices.

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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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