妊娠滋养细胞瘤的最新进展

N.J. Sebire, I. Lindsay, R.A. Fisher
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引用次数: 9

摘要

妊娠滋养细胞瘤是指以母体滋养细胞增生为特征的一系列疾病,包括部分和完全葡萄胎(HM)、侵袭性葡萄胎、绒毛膜癌和胎盘部位滋养细胞瘤及其变体。随着近年来妊娠早期并发症管理的变化,大多数HMs现在在妊娠早期晚期排出,此时,现在认识到,它们的组织病理学特征,尽管具有特征性,但可能与传统上描述的妊娠中期排出不同。鉴于这些表现的变化,本文提出了最新的组织病理学标准,并讨论了具体的附加问题,包括分子遗传学的最新进展、辅助调查、复发风险、持续性滋养细胞瘤的发展、胎盘内绒毛膜癌和伴有共存胎儿的痣。
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Recent advances in gestational trophoblastic neoplasia

Gestational trophoblastic neoplasia refers to the spectrum of conditions characterised by proliferation of conceptus-derived trophoblast, and includes partial and complete hydatidiform mole (HM), invasive mole, choriocarcinoma and placental site trophoblastic tumour and its variants. With changes in the management of early pregnancy complications in recent years, the majority of HMs are now evacuated in the late first trimester, at which time, it is now recognised, their histopathological features, although characteristic, may differ from those traditionally described following second-trimester evacuation. In view of these changes in presentation, updated histopathological criteria are presented and specific additional issues discussed, including recent advances in molecular genetics, ancillary investigations, recurrence risk, development of persistent trophoblastic neoplasia, intraplacental choriocarcinoma and mole with coexisting fetus.

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