脂蛋白颗粒转运氧脂素及其对心脏代谢和神经系统疾病的功能意义。

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in lipid research Pub Date : 2023-11-17 DOI:10.1016/j.plipres.2023.101265
Nuanyi Liang , Brian A. Harsch , Sitong Zhou , Alison Borkowska , Gregory C. Shearer , Rima Kaddurah-Daouk , John W. Newman , Kamil Borkowski
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引用次数: 0

摘要

脂蛋白代谢对炎症至关重要。虽然外周神经系统和中枢神经系统(CNS)具有独立但相互联系的脂蛋白系统,但脂蛋白代谢受损与心脏代谢和神经系统疾病都有关系。尽管对脂蛋白的组成、结构和功能进行了大量的研究,但脂蛋白氧脂质谱、它们对脂蛋白功能的影响及其潜在的生物学意义尚不清楚。脂蛋白携带大部分的循环氧脂素。重要的是,脂蛋白介导的氧脂转运允许这些脂质介质的内分泌信号,长期以来被认为只有自分泌和旁分泌功能。血浆脂蛋白氧脂素组成的改变可直接影响脂蛋白代谢细胞的炎症反应。到目前为止,对中枢神经系统脂蛋白氧脂素的类似研究尚不存在。然而,由于APOE4与阿尔茨海默病相关的小胶质细胞功能障碍和氧化脂素失调有关,因此APOE4依赖性脂蛋白氧化脂素在神经系统病理中的调节作用被提出。这样的研究对于弥合外周和中枢神经系统中与氧脂素和脂蛋白相关疾病之间的知识差距至关重要。在本文中,我们在总结了现有的关于脂蛋白氧脂质分析方法的文献后,强调了脂蛋白在氧脂质运输中的重要性,并认为了解脂蛋白氧脂质的区隔化和分布可能会从根本上改变我们对脂蛋白在心脏代谢和神经系统疾病中的作用的认识。
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Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders

Lipoprotein metabolism is critical to inflammation. While the periphery and central nervous system (CNS) have separate yet connected lipoprotein systems, impaired lipoprotein metabolism is implicated in both cardiometabolic and neurological disorders. Despite the substantial investigation into the composition, structure and function of lipoproteins, the lipoprotein oxylipin profiles, their influence on lipoprotein functions, and their potential biological implications are unclear. Lipoproteins carry most of the circulating oxylipins. Importantly, lipoprotein-mediated oxylipin transport allows for endocrine signaling by these lipid mediators, long considered to have only autocrine and paracrine functions. Alterations in plasma lipoprotein oxylipin composition can directly impact inflammatory responses of lipoprotein metabolizing cells. Similar investigations of CNS lipoprotein oxylipins are non-existent to date. However, as APOE4 is associated with Alzheimer's disease-related microglia dysfunction and oxylipin dysregulation, ApoE4-dependent lipoprotein oxylipin modulation in neurological pathologies is suggested. Such investigations are crucial to bridge knowledge gaps linking oxylipin- and lipoprotein-related disorders in both periphery and CNS. Here, after providing a summary of existent literatures on lipoprotein oxylipin analysis methods, we emphasize the importance of lipoproteins in oxylipin transport and argue that understanding the compartmentalization and distribution of lipoprotein oxylipins may fundamentally alter our consideration of the roles of lipoprotein in cardiometabolic and neurological disorders.

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来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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