p53和RNA病毒:拉锯战。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-11-20 DOI:10.1002/wrna.1826
Apala Pal, Sachin Kumar Tripathi, Priya Rani, Meghana Rastogi, Saumitra Das
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引用次数: 0

摘要

宿主因子在病毒感染中起着至关重要的作用,它们与病毒蛋白的相互作用是建立有效发病机制的必要条件。P53是一种通过控制细胞周期进程和细胞存活来维持基因组完整性的宿主因子。它是一种众所周知的肿瘤抑制蛋白,可被各种应激信号激活,从而调节细胞通路。不同应激的细胞结果与p53动力学密切相关,包括其在基因、mRNA或蛋白质水平上的改变。P53还有助于免疫反应,从而消除病毒病原体。反过来,病毒已经进化出破坏p53介导的宿主反应的策略,以改善其生命周期和发病机制。一些病毒减弱野生型p53 (WT-p53)的功能以成功致病,包括降解和隔离p53。相反,其他一些研究通过转录/翻译水平的调控利用WT-p53功能来传播感染。这类宿主因子的重要性日益显现的一个领域是导致致命病毒感染的正链RNA病毒。在这篇综述中,我们深入研究了正链RNA病毒利用p53调节来建立感染的所有可能机制。这篇文章被分类为:RNA与蛋白质和其他分子的相互作用>蛋白质-RNA相互作用:功能意义翻译>在疾病和发展中的调控RNA >在疾病中的RNA。
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p53 and RNA viruses: The tug of war.

Host factors play essential roles in viral infection, and their interactions with viral proteins are necessary for establishing effective pathogenesis. p53 is a host factor that maintains genomic integrity by controlling cell-cycle progression and cell survival. It is a well-known tumor suppressor protein that gets activated by various stress signals, thereby regulating cellular pathways. The cellular outcomes from different stresses are tightly related to p53 dynamics, including its alterations at gene, mRNA, or protein levels. p53 also contributes to immune responses leading to the abolition of viral pathogens. In turn, the viruses have evolved strategies to subvert p53-mediated host responses to improve their life cycle and pathogenesis. Some viruses attenuate wild-type p53 (WT-p53) function for successful pathogenesis, including degradation and sequestration of p53. In contrast, some others exploit the WT-p53 function through regulation at the transcriptional/translational level to spread infection. One area in which the importance of such host factors is increasingly emerging is the positive-strand RNA viruses that cause fatal viral infections. In this review, we provide insight into all the possible mechanisms of p53 modulation exploited by the positive-strand RNA viruses to establish infection. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications Translation > Regulation RNA in Disease and Development > RNA in Disease.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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