{"title":"Ca2+信号在表观遗传机制调控中的作用。","authors":"Andrés Hernández-Oliveras, Angel Zarain-Herzberg","doi":"10.1016/j.ceca.2023.102836","DOIUrl":null,"url":null,"abstract":"<div><p>Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca<sup>2+</sup>) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca<sup>2+</sup> signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca<sup>2+</sup> signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca<sup>2+</sup><span>-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca</span><sup>2+</sup>-sensing proteins modulate their activity and intracellular localization. Thus, Ca<sup>2+</sup> signaling is an important regulator of epigenetic mechanisms. Moreover, Ca<sup>2+</sup> signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca<sup>2+</sup> signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.</p></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of Ca2+-signaling in the regulation of epigenetic mechanisms\",\"authors\":\"Andrés Hernández-Oliveras, Angel Zarain-Herzberg\",\"doi\":\"10.1016/j.ceca.2023.102836\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca<sup>2+</sup>) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca<sup>2+</sup> signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca<sup>2+</sup> signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca<sup>2+</sup><span>-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca</span><sup>2+</sup>-sensing proteins modulate their activity and intracellular localization. Thus, Ca<sup>2+</sup> signaling is an important regulator of epigenetic mechanisms. Moreover, Ca<sup>2+</sup> signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca<sup>2+</sup> signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.</p></div>\",\"PeriodicalId\":9678,\"journal\":{\"name\":\"Cell calcium\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2023-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell calcium\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0143416023001471\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell calcium","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143416023001471","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
The role of Ca2+-signaling in the regulation of epigenetic mechanisms
Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca2+) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca2+ signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca2+ signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca2+-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca2+-sensing proteins modulate their activity and intracellular localization. Thus, Ca2+ signaling is an important regulator of epigenetic mechanisms. Moreover, Ca2+ signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca2+ signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.
期刊介绍:
Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include:
Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling
Influence of calcium regulation in affecting health and disease outcomes