Ca2+信号在表观遗传机制调控中的作用。

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2023-11-21 DOI:10.1016/j.ceca.2023.102836
Andrés Hernández-Oliveras, Angel Zarain-Herzberg
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引用次数: 0

摘要

表观遗传机制调节多种细胞功能,如基因表达、染色质构象和稳定性,其失调可能导致包括癌症在内的多种疾病。表观遗传药物目前正在广泛的疾病研究中,但参与调节表观遗传机制的细胞过程尚未完全了解。钙(Ca2+)信号调节多种细胞机制,如增殖、基因表达和代谢等。此外,Ca2+信号还与神经系统疾病、心脏病和癌症等疾病有关。有证据表明,Ca2+信号和表观遗传学参与相同的细胞功能,这表明两种机制之间可能存在相互作用。Ca2+激活的转录因子调节染色质重塑复合物进入靶基因的募集,Ca2+感应蛋白调节其活性和细胞内定位。因此,Ca2+信号是表观遗传机制的重要调节因子。此外,Ca2+信号激活表观遗传机制,而表观遗传机制反过来调节参与Ca2+信号传导的基因,这表明两种机制之间可能存在反馈。理解表观遗传学是如何被调控的可能会导致开发更好的治疗方法。
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The role of Ca2+-signaling in the regulation of epigenetic mechanisms

Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca2+) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca2+ signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca2+ signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca2+-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca2+-sensing proteins modulate their activity and intracellular localization. Thus, Ca2+ signaling is an important regulator of epigenetic mechanisms. Moreover, Ca2+ signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca2+ signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.

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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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