生物正交连接和生物偶联的最新进展。

IF 8.6 2区化学 Q1 Chemistry Topics in Current Chemistry Pub Date : 2023-11-22 DOI:10.1007/s41061-023-00445-6

Florian M. Zielke, Floris P. J. T. Rutjes

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引用次数: 0

摘要

创造具有超越自然工具箱功能的生物分子的愿望导致了生物相容性和选择性方法和试剂的发展，每种方法和试剂都有不同的范围和局限性。在本综述中，我们重点介绍了2016年至2023年生物偶联领域的最新进展。首先，将讨论利用氨基酸的特异性反应性来实现(金属介导的)蛋白质功能化，然后讨论用于修饰生物分子的生物偶联的新型生物正交试剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Advances in Bioorthogonal Ligation and Bioconjugation

The desire to create biomolecules modified with functionalities that go beyond nature’s toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconjugation from 2016 to 2023. First, (metal-mediated) protein functionalization by exploiting the specific reactivity of amino acids will be discussed, followed by novel bioorthogonal reagents for bioconjugation of modified biomolecules.

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.