硝普钠作为精神分裂症的辅助治疗可降低Ndel1寡肽酶活性。

IF 3.6 3区 医学 Q1 PSYCHIATRY Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-11-23 DOI:10.47626/1516-4446-2023-3315
João Victor Nani, Juliana Mayumi Ushirohira, Nicholas J Bradshaw, João Paulo Machado-de-Sousa, Jaime Eduardo Cecílio Hallak, Mirian A F Hayashi
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引用次数: 0

摘要

目的:精神分裂症(SCZ)是一种持续无视临床医生和研究人员的致残障碍。我们研究了硝普钠(sNP)在SCZ动物模型中的作用,并作为患者的附加治疗,以及sNP治疗与nDel1酶活性之间的关系,该酶参与了该疾病的病理生理,这在之前已经提出。方法:在自发性高血压大鼠(SHR;2.5或5.0 mg/kg),在SCZ患者的双盲试验中(0.5 μg/kg/min)。结果:与对照组相比,sNP输注后SHR血液中Ndel1活性显著降低,接受sNP治疗的患者与安慰剂相比(t = 7.756, df = 97, p < 0.0001, dcohen = 1.44)。Ndel1活性在基线和输注结束之间的降低仅在接受sNP治疗的患者中可见。结论:我们的研究结果表明,SCZ患者可能受益于sNP辅助治疗,Ndel1酶是该疾病精神病理的候选生物标志物。未来的研究应该关注Ndel1在SCZ中的作用,以及sNP和具有相似作用的药物对动物和患者的潜在影响。
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Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces Ndel1 oligopeptidase activity.

Objective: To assess nuclear distribution element-like 1 (Ndel1) enzyme activity following acute administration of sodium nitroprusside (sNP) in a rodent model of schizophrenia (SCZ) and in a cohort of chronic SCZ patients.

Methods: Ndel1 activity was measured following sNP infusions in spontaneously hypertensive rats (SHR) (2.5 or 5.0 mg/kg) and in a double-blind randomized trial with 15 SCZ patients (0.5 µg/kg/min). Patients were randomized into two groups (group I: n=7; group II: n=8), with one group receiving placebo and the other sNP in phase A. In phase B, the groups switched treatments. sNP was administered as an infusion of 0.5 µg/kg/min, for 4 h, while placebo was a 5% glucose solution infused under the same conditions. The infusions were administered once weekly over 4 weeks. Psychopathology was assessed using the 18-item figure 5 (BPRS-18 - Bech's version) and the negative subscale of the Positive and Negative Syndrome Scale.

Results: Ndel1 activity was significantly reduced after sNP infusion in SHR and in patients receiving sNP (t = 7.756, degrees of freedom [df] = 97, p < 0.0001, dcohen=1.44) compared to placebo. Reduced Ndel1 activity from baseline to the end of infusion was only seen in patients after treatment with sNP.

Conclusion: SCZ patients may benefit from adjunctive therapy with sNP and that the Ndel1 enzyme is a candidate biomarker of psychopathology in the disorder. Future research should look into the role of Ndel1 in SCZ and the potential effects of sNP and drugs with similar profiles of action in both animals and patients.

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来源期刊
Revista Brasileira de Psiquiatria
Revista Brasileira de Psiquiatria 医学-精神病学
CiteScore
6.60
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.
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