基于场效应晶体管的生物传感器检测阿尔茨海默病生物标志物。

IF 4.9 3区工程技术 Q1 CHEMISTRY, ANALYTICAL Biosensors-Basel Pub Date : 2023-11-17 DOI:10.3390/bios13110987

Phan Gia Le, Seong Hye Choi, Sungbo Cho

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引用次数: 0

摘要

阿尔茨海默病(AD)与神经退行性变密切相关，可导致痴呆和认知功能障碍，尤其是65岁以上的人群。生物标志物的检测在阿尔茨海默病的诊断和治疗中起着关键作用，特别是在发病阶段。基于场效应晶体管(FET)的传感器是新兴的器件，由于其在超低浓度下识别各种生物标志物的关键能力而引起了相当大的关注。因此，FET广泛用于AD生物标志物检测。本文详细介绍了场效应管的典型特征及其工作机制。此外，本文还对AD生物标志物的检测和FET生物传感器在该研究领域的适用性进行了概述和讨论。此外，还讨论了FET器件在AD诊断中的应用趋势和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alzheimer's Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor.

Alzheimer's disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor (FET)-based sensors are emerging devices that have drawn considerable attention due to their crucial ability to recognize various biomarkers at ultra-low concentrations. Thus, FET is broadly manipulated for AD biomarker detection. In this review, an overview of typical FET features and their operational mechanisms is described in detail. In addition, a summary of AD biomarker detection and the applicability of FET biosensors in this research field are outlined and discussed. Furthermore, the trends and future prospects of FET devices in AD diagnostic applications are also discussed.

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来源期刊

Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

6.60

自引率

14.80%

发文量

983

审稿时长

11 weeks

期刊介绍： Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.