体内淀粉样蛋白-β荧光探针的研究进展

IF 4.9 3区 工程技术 Q1 CHEMISTRY, ANALYTICAL Biosensors-Basel Pub Date : 2023-11-19 DOI:10.3390/bios13110990
Zhen-Yu Zhang, Ze-Jun Li, Ying-Hao Tang, Liang Xu, De-Teng Zhang, Tian-Yi Qin, Ya-Long Wang
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引用次数: 0

摘要

阿尔茨海默病(AD)是一种神经退行性疾病。由于其病理机制复杂,病因尚不清楚。淀粉样蛋白-β (Aβ)是AD的主要病理标志物之一,在AD的发生发展中起着重要作用。a β的沉积不仅与神经元的退行性变有关,还可激活星形胶质细胞和小胶质细胞的活化、血脑屏障的破坏、微循环的改变等一系列病理事件,是AD患者脑病变和死亡的主要原因。因此,开发高效可靠的a β特异性探针对于AD的早期诊断和治疗至关重要。本文重点综述了近年来小分子荧光探针在体内Aβ成像中的应用。这些探针有效地定位了a β在体内的存在,为AD的早期诊断提供了途径,并为未来a β特异性探针的设计提供了启示。
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Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo.

Alzheimer's disease (AD) is a neurodegenerative disease. Due to its complex pathological mechanism, its etiology is not yet clear. As one of the main pathological markers of AD, amyloid-β (Aβ) plays an important role in the development of AD. The deposition of Aβ is not only related to the degeneration of neurons, but also can activate a series of pathological events, including the activation of astrocytes and microglia, the breakdown of the blood-brain barrier, and the change in microcirculation, which is the main cause of brain lesions and death in AD patients. Therefore, the development of efficient and reliable Aβ-specific probes is crucial for the early diagnosis and treatment of AD. This paper focuses on reviewing the application of small-molecule fluorescent probes in Aβ imaging in vivo in recent years. These probes efficiently map the presence of Aβ in vivo, providing a pathway for the early diagnosis of AD and providing enlightenment for the design of Aβ-specific probes in the future.

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来源期刊
Biosensors-Basel
Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍: Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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