金黄色葡萄球菌的流行病学、病理生理、临床表现及纳米治疗作为对抗耐甲氧西林金黄色葡萄球菌的一种有前途的方法的应用。

IF 4.9 4区 医学 Q1 PARASITOLOGY Pathogens and Global Health Pub Date : 2024-05-01 Epub Date: 2023-11-25 DOI:10.1080/20477724.2023.2285187
Raghad H F Bashabsheh, O'la Al-Fawares, Iyad Natsheh, Roba Bdeir, Rozan O Al-Khreshieh, Hasan H F Bashabsheh
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引用次数: 0

摘要

金黄色葡萄球菌是一种革兰氏阳性细菌,是成年人发病和死亡的最普遍的传染病相关原因之一。这种病原体可以引发广泛的疾病,从败血症和肺炎到可能致命的严重皮肤感染。在这篇综述中,我们将提供金黄色葡萄球菌的概述,并讨论广泛的文献流行病学,传播,遗传多样性,进化和抗生素耐药菌株,特别是耐甲氧西林金黄色葡萄球菌(MRSA)。虽然金黄色葡萄球菌产生的许多不同的毒力因子已被研究作为治疗靶点,但本文综述了最近的纳米技术方法,这些方法使用具有原子或分子尺寸的材料,并被用于诊断、治疗或消除金黄色葡萄球菌的活性。最后,对金黄色葡萄球菌决定因子、抗生素耐药性和纳米技术的作用和贡献有了更深入的了解和更清晰的把握,将有助于我们制定抗毒策略,以应对金黄色葡萄球菌有效抗生素日益短缺的问题。
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Staphylococcus aureus epidemiology, pathophysiology, clinical manifestations and application of nano-therapeutics as a promising approach to combat methicillin resistant Staphylococcus aureus.

Staphylococcus aureus is a Gram-positive bacterium and one of the most prevalent infectious disease-related causes of morbidity and mortality in adults. This pathogen can trigger a broad spectrum of diseases, from sepsis and pneumonia to severe skin infections that can be fatal. In this review, we will provide an overview of S. aureus and discuss the extensive literature on epidemiology, transmission, genetic diversity, evolution and antibiotic resistance strains, particularly methicillin resistant S. aureus (MRSA). While many different virulence factors that S. aureus produces have been investigated as therapeutic targets, this review examines recent nanotechnology approaches, which employ materials with atomic or molecular dimensions and are being used to diagnose, treat, or eliminate the activity of S. aureus. Finally, having a deeper understanding and clearer grasp of the roles and contributions of S. aureus determinants, antibiotic resistance, and nanotechnology will aid us in developing anti-virulence strategies to combat the growing scarcity of effective antibiotics against S. aureus.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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