胆管癌免疫微环境及免疫治疗进展

Xinyu Shao
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引用次数: 0

摘要

胆管癌(CCA)是一组整体预后较差的消化系统恶性肿瘤。诊断晚、治疗有限是CCA的主要问题。免疫治疗是一种很有希望改善预后的方法,但CCA肿瘤微环境的免疫抑制阻碍了免疫治疗的发展和实施。因此,充分了解CCA及其肿瘤免疫微环境(TiME)的复杂组成,可以更好地了解CCA的发病机制和耐药机制,有助于发现新的免疫治疗靶点。本文综述了近年来胆管癌免疫微环境的相关研究,全面探讨了胆管癌免疫微环境的组成,并介绍了胆管癌免疫治疗及免疫联合治疗的研究进展。
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Immune microenvironment and progress in immunotherapy of cholangiocarcinoma

Cholangiocarcinoma (CCA) is a group of malignant digestive system tumors with a poor overall prognosis. Late diagnosis and limited treatment are the main problems of CCA. Immunotherapy is a promising method to improve the prognosis, but the immunosuppression of CCA tumor microenvironment hinders the development and implementation of immunotherapy. Therefore, a full understanding of the complex components of CCA and its tumor immune microenvironment (TiME) can better understand the pathogenesis and drug resistance mechanism of CCA and contribute to the discovery of new immunotherapy targets. This article reviews the TiME related research on CCA, comprehensively discusses the components of the immune microenvironment of cholangiocarcinoma, and introduces the research progress of immunotherapy and immune combination therapy for CCA.

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