{"title":"从贯叶连翘枝和叶中提取的具有抗血管生成活性的三种新酰基间苯三酚。","authors":"Hao Zhang, Kunling Wang, Fan Chen","doi":"10.1080/14786419.2023.2278176","DOIUrl":null,"url":null,"abstract":"<p><p>Three new acylphloroglucinols were isolated from the branches and leaves of <i>Hypericum perforatum</i> L., named as hyperipersions A-C (<b>1-3</b>), together with three known compounds which were identified as elegaphenone (<b>4</b>), 2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester (<b>5</b>) and 2,3-methylenedioxyxanthone (<b>6</b>), respectively. The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR analysis. Their antiangiogenic activities were studied against HUVECs. The IC<sub>50</sub> value of compound <b>3</b> was 2.39 ± 0.21 <i>μ</i>M against HUVECs, which was stronger than vatalanib, and other compounds had moderate antiangiogenic activity.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4134-4140"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of <i>Hypericum perforatum</i> L. with antiangiogenic activities.\",\"authors\":\"Hao Zhang, Kunling Wang, Fan Chen\",\"doi\":\"10.1080/14786419.2023.2278176\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Three new acylphloroglucinols were isolated from the branches and leaves of <i>Hypericum perforatum</i> L., named as hyperipersions A-C (<b>1-3</b>), together with three known compounds which were identified as elegaphenone (<b>4</b>), 2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester (<b>5</b>) and 2,3-methylenedioxyxanthone (<b>6</b>), respectively. The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR analysis. Their antiangiogenic activities were studied against HUVECs. The IC<sub>50</sub> value of compound <b>3</b> was 2.39 ± 0.21 <i>μ</i>M against HUVECs, which was stronger than vatalanib, and other compounds had moderate antiangiogenic activity.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"4134-4140\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2023.2278176\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2023.2278176","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of Hypericum perforatum L. with antiangiogenic activities.
Three new acylphloroglucinols were isolated from the branches and leaves of Hypericum perforatum L., named as hyperipersions A-C (1-3), together with three known compounds which were identified as elegaphenone (4), 2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester (5) and 2,3-methylenedioxyxanthone (6), respectively. The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR analysis. Their antiangiogenic activities were studied against HUVECs. The IC50 value of compound 3 was 2.39 ± 0.21 μM against HUVECs, which was stronger than vatalanib, and other compounds had moderate antiangiogenic activity.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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