糖原合成酶激酶3信号在体内神经再生中的作用。

IF 5.3 2区 生物学 Q2 CELL BIOLOGY Journal of Molecular Cell Biology Pub Date : 2024-04-10 DOI:10.1093/jmcb/mjad075
Jing Zhang, Shu-Guang Yang, Feng-Quan Zhou
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引用次数: 0

摘要

糖原合成酶激酶3 (GSK3)信号在体外和体内神经发育调控中发挥着重要而广泛的作用。在这里,我们回顾了gsk3调节外周和中枢神经系统轴突再生的最新发现,并讨论了该领域的一些有争议的发现。总的来说,目前的证据表明,GSK3β信号作为PI3K-AKT通路的重要下游介质,与mTORC1通路平行调节轴突再生。具体来说,mTORC1通路主要通过调节帽依赖性蛋白翻译来支持轴突再生,而GSK3β信号可能参与调节n6 -甲基腺苷(m6A) mRNA甲基化介导的帽非依赖性蛋白翻译。此外,GSK3信号也在神经再生过程中重塑神经元转录组景观中发挥关键作用。最后,我们提出了进一步阐明GSK3信号调控功能的分子机制,发现新的GSK3信号相关治疗靶点的研究方向。总之,我们希望提供GSK3信号如何调节体内神经再生的最新和有见地的概述。
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Glycogen synthase kinase 3 signaling in neural regeneration in vivo.

Glycogen synthase kinase 3 (GSK3) signaling plays important and broad roles in regulating neural development in vitro and in vivo. Here, we reviewed recent findings of GSK3-regulated axon regeneration in vivo in both the peripheral and central nervous systems and discussed a few controversial findings in the field. Overall, current evidence indicates that GSK3β signaling serves as an important downstream mediator of the PI3K-AKT pathway to regulate axon regeneration in parallel with the mTORC1 pathway. Specifically, the mTORC1 pathway supports axon regeneration mainly through its role in regulating cap-dependent protein translation, whereas GSK3β signaling might be involved in regulating N6-methyladenosine mRNA methylation-mediated, cap-independent protein translation. In addition, GSK3 signaling also plays a key role in reshaping the neuronal transcriptomic landscape during neural regeneration. Finally, we proposed some research directions to further elucidate the molecular mechanisms underlying the regulatory function of GSK3 signaling and discover novel GSK3 signaling-related therapeutic targets. Together, we hope to provide an updated and insightful overview of how GSK3 signaling regulates neural regeneration in vivo.

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来源期刊
CiteScore
9.60
自引率
1.80%
发文量
1383
期刊介绍: The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.
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