集中行为干预对脑大麻素信号和内感受功能的影响:对情绪和焦虑的影响

Otto Muzik , Timothy Mann , John Kopchick , Asadur Chowdury , Mario Yacou , Jamie Vadgama , Daniel Bonello , Vaibhav A. Diwadkar
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摘要

威姆霍夫方法(WHM)是一种行为干预技术,包括深呼吸练习、寒冷暴露和冥想。鉴于大麻素系统通过负反馈机制调节神经递质释放的关键作用,旨在维持网络稳态,我们的研究调查了4名男性对照者在使用F18]FMPEP-d2 PET示踪剂(一种逆CB1受体激动剂)纵向(6周)WHM干预后大麻素1型(CB1)受体结合的变化。结果显示,CB1受体结合的全球增加了约20%,其中与内感受网络相关的大脑区域增加最多,如前扣带、眶额皮质OFC、前岛皮质(AIC)和脑干。此外,在相同的参与者中,使用全身冷应激范式系统地唤起交感和副交感神经反应。干预后,参与者的脑岛前部和眼窝额叶皮层等区域的活动增加,这两个区域分别属于大脑的内感受(AIC)和执行(OFC)子网络。我们的研究结果表明,相对较短的6周WHM干预对与应激抵抗、情绪、焦虑和内感受功能相关的大脑标志物产生了积极影响。
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The impact of a focused behavioral intervention on brain cannabinoid signaling and interoceptive function: Implications for mood and anxiety

The Wim Hof method (WHM) is a behavioral intervention technique that consists of deep breathing exercises, cold exposure and meditation. In light of the crucial role of the cannabinoid system in modulating neurotransmitter release through a negative feedback mechanism that aims at the maintenance of network homeostasis, our study investigated changes in cannabinoid type 1 (CB1) receptor binding following a longitudinal (6 weeks) WHM intervention in 4 male controls using the F18]FMPEP-d2 PET tracer, an inverse CB1 receptor agonist. Results revealed a global increase in CB1 receptor binding of ∼20%, with largest increases found in brain regions associated with the interoceptive network such as the anterior cingulate, the orbitofrontal cortex OFC), the anterior insular cortex (AIC) and the brainstem. Furthermore, in the same participants a whole-body cold-stress paradigm was used to systematically evoke sympathetic and parasympathetic responses. Post-intervention, participants showed increased engagement of regions like the anterior insula and the orbitofrontal cortex that have been respectively classified as belonging to the brain’s interoceptive (AIC) and executive (OFC) sub-networks. Our results suggest that a relatively short 6-week WHM intervention positively impacts brain markers that have been associated with stress resistance, mood, anxiety and interoceptive function.

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