CHECH 研究:中国天津妊娠期前瞻性队列研究:氯暴露与儿童健康

Yuxuan Zhao , Jing Wang , Gongshu Liu , Yeganeh Ataei , Carl-Gustaf Bornehag , Wei Liu , Qinghao Zhang , Jianjun Huang , Peizhe Sun , Yuexia Sun
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摘要

化学品暴露与儿童健康(CHECH)研究是一项正在中国天津进行的妊娠队列研究。本文介绍了该研究的背景、目的和研究设计,可供今后的研究人员在设计和开展类似研究时参考。干扰内分泌的化学物质(EDCs)的大量存在及其潜在的不良健康后果令人担忧。更值得注意的是,发育中的胎儿和婴儿更容易受到 EDCs 暴露的影响。CHECH研究旨在调查中国儿童早期暴露于多种EDCs(邻苯二甲酸盐及其代谢物、双酚A及其替代品、全氟化合物和多溴联苯醚)对其性发育、神经发育、新陈代谢和生长以及哮喘和过敏等多种健康结果的影响。2017年5月至2021年4月,天津市共招募了2238名孕妇,响应率为90%。在这些孕妇中,有资料可查的新生儿有 2255 名,其中包括 47 对双胞胎。研究人员采集了孕妇和儿童的尿液样本,并从孕期和婴儿期的家庭环境中采集了空气和灰尘样本。通过体检和问卷调查收集了有关儿童健康的信息。CHECH研究收集了多个时间点的暴露信息和健康结果,将有助于了解产前暴露于EDCs及其对儿童健康的影响,从而促进旨在减少暴露和相关健康风险的风险评估的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The CHECH study: A prospective pregnancy cohort study on CHemical exposure and children's health in Tianjin, China

The CHemical Exposure and Children's Health (CHECH) study is an ongoing pregnancy cohort study in Tianjin, China. This paper describes the background, aim and the study design, which can be followed by future researchers to design and conduct similar studies. The abundance and the potential adverse health outcomes of endocrine disrupting chemicals (EDCs) is concerning. More notably, developing fetuses and infants are more vulnerable to EDCs exposure. The CHECH study aims to investigate the importance of early life exposure to multiple EDCs (phthalates and their metabolites, bisphenol A and their substitutes, perfluorinated compounds and poly brominated diphenyl ethers) for multiple health outcomes in Chinese children, namely sexual development, neurodevelopment, metabolism and growth, as well as asthma and allergy. A total of 2238 pregnant women were recruited in Tianjin from May 2017 to April 2021 with a response rate of 90 %. Among these women, 2255 children were born with available information, including 47 pairs of twins. Urine samples were collected from pregnant women and children, while air and dust samples were obtained from the home environment during pregnancy and infancy periods. Information on children's health was gathered through physical examinations and questionnaires. The CHECH study, which collected exposure information and health outcomes at multiple time points, will contribute to the understanding of prenatal exposure to EDCs and their impact on children's health, thereby facilitating the development of risk assessments aimed at reducing exposure and associated health risks.

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来源期刊
Hygiene and environmental health advances
Hygiene and environmental health advances Environmental Science (General)
CiteScore
1.10
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0
审稿时长
38 days
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