Hygiene and environmental health advances最新文献

Eye-level greenspace exposure and residents’ diabetes/glucose homeostasis status in Northeast China: A gender perspective 东北地区眼平绿地暴露与居民糖尿病/葡萄糖稳态状态：性别视角

IF 2.7

Hygiene and environmental health advances

Pub Date : 2026-01-09 DOI: 10.1016/j.heha.2026.100170

Changda Yu , Zeeshan Mohammed , Hong-Zhi Zhang , Dao-Sen Wang , Yun-Ting Zhang , Guang-Hui Dong , Mei-Po Kwan , Li-Zi Lin

Diabetes is a prevalent chronic disease. Its interaction with environmental factors, especially greenspace, has garnered substantial scholarly attention. However, prevailing research has yielded disparate outcomes. The objective of our research was to elucidate the association between individual eye-level greenspace exposure and diabetes risk, employing data acquired from the 33 Communities Chinese Health Study, comprising 15,477 participants in Liaoning Province, China. Greenspace exposure was measured using the Greenness Visibility Index (GVI) from street view images, while the markers of blood glucose were ascertained via a systematic oral glucose tolerance test. Our findings indicate that eye-level greenspace exposure retains a substantial inverse association with the risk of diabetes, fasting and 2-hour glucose levels. Nevertheless, no significant associations were identified between eye-level greenspace exposure and either fasting or 2-hour insulin levels when gender was not considered. However, upon taking gender into consideration, a positive association was manifested between greenspace exposure and fasting insulin levels in male subjects, while a reverse association was exhibited in females. Regarding markers of Homeostasis Model Assessment, eye-level greenspace exposure had a significant negative relationship with the HOMA-IR index, which implies a conceivable connection with diminished levels of insulin resistance. Concurrently, a positive association was discerned between eye-level greenspace exposure and the HOMA-β index, hinting at a possible relationship with augmented beta-cell functionality. Nonetheless, these associations varied across different greenspace components and gender groups. This study provides novel evidence in revealing a negative association between individual eye-level greenspace exposure in residential environments and the prevalence of diabetes. It also sheds light on the intricate relationships between eye-level greenspace exposure and diverse markers of blood glucose homeostasis.

糖尿病是一种普遍的慢性疾病。它与环境因素，特别是绿色空间的相互作用，已经引起了大量的学术关注。然而，主流研究得出了截然不同的结果。我们的研究目的是阐明个体眼平绿色空间暴露与糖尿病风险之间的关系，采用来自33个社区的中国健康研究数据，包括中国辽宁省的15,477名参与者。通过街景图像中的绿色可见度指数（GVI）来测量绿地暴露，而通过系统口服葡萄糖耐量试验来确定血糖指标。我们的研究结果表明，与眼睛水平的绿色空间暴露与糖尿病、禁食和2小时血糖水平的风险保持着实质性的负相关。然而，在不考虑性别的情况下，没有发现眼睛水平的绿色空间暴露与禁食或2小时胰岛素水平之间有显著关联。然而，考虑到性别因素，绿地暴露与男性受试者的空腹胰岛素水平呈正相关，而女性受试者的空腹胰岛素水平呈负相关。关于稳态模型评估的标记，眼睛水平的绿色空间暴露与HOMA-IR指数呈显著负相关，这意味着可能与胰岛素抵抗水平降低有关。同时，眼睛水平的绿色空间暴露与HOMA-β指数之间存在正相关，暗示可能与增强的β细胞功能有关。然而，这些关联在不同的绿色空间组成部分和性别群体中有所不同。本研究提供了新的证据，揭示了个人在住宅环境中接触绿色空间与糖尿病患病率之间的负相关关系。它还揭示了眼睛水平的绿色空间暴露与血糖稳态的各种标记物之间的复杂关系。

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引用次数: 0

Environmental health disparities among elderly population in New York State 纽约州老年人口的环境健康差异

IF 2.7

Hygiene and environmental health advances

Pub Date : 2026-01-05 DOI: 10.1016/j.heha.2026.100168

Randy T. Tangang , Yineng Chen , Junrong Ma , Samantha Friedman , Imran Hossain Mithu , Zhongguo Huang , Najm Alsadat Madani , Bennett Gayle DeeDee , Xiaobo X Romeiko , Shao Lin

Background

With increasing environmental disparities and understudied older adult populations, our study aims to evaluate whether older adults and subgroups are more likely to live in communities with higher environmental hazards.

Methods

Using 2014–2019 data from the American Community Survey, we identified census county subdivisions with elevated proportions (≥ 75%) of four subgroups: adults aged ≥ 65 years, older adults living alone, older adults below the poverty line, and Black older adults, while comparing them with other groups. We integrated data for extreme weather and several air pollutants (UFP, PM₂.₅, O₃, SO₂, NH₃, NO_2, and CO), as well as the Disaster Risk Index derived from FEMA, using the 75th percentile as the cutoff point for these exposures. We then applied a multivariate mixed-effects logistic regression to examine exposure disparities.

Results

Older adults living alone resided in areas with greater vulnerability to disaster (P < 0.001). Additionally, poor older adults were more likely to live in areas with multiple environmental hazards, including higher levels of UFP (OR: 1.89, 95% CI: 1.11–3.21) and SO₂ (OR: 1.68, 95% CI: 1.04–2.70), 5–8 extreme events (OR=3.1, 95% CI: 1.90–5.12), as well as significant overall disaster risk index. Furthermore, areas with a higher % of Black older adults faced more environmental hazards, such as a higher likelihood of living in communities with high levels of extreme heat (OR: 4.08; 95% CI: 1.69–9.86), high PM₂.₅ (OR: 2.69; 95% CI: 1.43–5.05), and UFP (OR: 2.1; 95% CI: 1.26–3.49), as well as multiple extreme events (OR=2.18, 95%CI: 1.36–3.64 for 1–4 events; OR=14.83, 95%CI: 8.54–26.77 for 5–8 events).

Conclusion

We conclude that poor or Black older adults, face significantly greater exposure to multiple environmental hazards, extreme weather events, and disaster vulnerabilities – compared to other subgroups.

随着环境差异的增加和对老年人口的研究不足，我们的研究旨在评估老年人和亚群体是否更有可能生活在环境危害较高的社区。方法利用2014-2019年美国社区调查（American Community Survey）的数据，我们确定了人口普查县细分中四个亚组比例较高（≥75%）的亚组：≥65岁的成年人、独居老年人、贫困线以下的老年人和黑人老年人，并将其与其他群体进行比较。我们整合了极端天气和几种空气污染物（UFP, PM 2）的数据。₅，O₃，SO₂，NH₃，NO2和CO)，以及来自FEMA的灾害风险指数，使用第75个百分位数作为这些风险的截止点。然后，我们应用多元混合效应逻辑回归来检验暴露差异。结果独居成年人居住的地区灾害易损性较高（P < 0.001）。此外，贫困老年人更有可能生活在多重环境危害的地区，包括较高水平的UFP （OR: 1.89, 95% CI: 1.11-3.21）和SO2 （OR: 1.68, 95% CI: 1.04-2.70）、5-8次极端事件（OR=3.1, 95% CI: 1.90-5.12），以及显著的总体灾害风险指数。此外，黑人老年人比例较高的地区面临更多的环境危害，例如生活在极端高温（OR: 4.08; 95% CI: 1.69-9.86）、高PM 2的社区的可能性更高。₅（OR: 2.69; 95%CI: 1.43-5.05）和UFP (OR: 2.1; 95%CI: 1.26-3.49)，以及多个极端事件（1-4事件OR=2.18, 95%CI: 1.36-3.64； 5-8事件OR=14.83, 95%CI: 8.54-26.77）。我们的结论是，与其他亚群体相比，贫困或黑人老年人面临的多种环境危害、极端天气事件和灾害脆弱性的暴露程度要高得多。

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引用次数: 0

Analyzing novel crowdsourced data sources and their role in understanding health outcomes of climate change-driven disasters 分析新的众包数据源及其在了解气候变化驱动的灾害的健康后果方面的作用

IF 2.7

Hygiene and environmental health advances

Pub Date : 2026-01-02 DOI: 10.1016/j.heha.2026.100167

Ramya S. Nayaka , Jennifer L. Chan , Michael S. Bloom , Hemant Purohit

Climate change has increased the frequency and severity of natural disasters that pose significant mental and physical health risks to the public during and after the event. Simultaneously, the dependency on social media to provide real-time information on how a disaster unfolds has also grown. We performed a scoping review using the Arksey and O’Malley framework to identify how crowdsourced data from social media platforms from the year 2010 to 2024 can be used to understand health outcomes during climate change-driven natural disasters in the United States. We reviewed thirty-four peer-reviewed articles using an interdisciplinary multi-method approach of human-machine collaboration. Two key research questions guided the review: (1) How is social media used to inform early warning systems for public health risks during climate-related disasters? and (2) Do social media indicators reflect disparities in health outcomes across different populations and geographic regions in such disaster events? The scoping review revealed four dominant thematic areas where the value of social media has been demonstrated: Health Concerns, Affected Populations, Disaster Impact & Response, and Environmental Factors. Social media platforms have frequently supported early warning efforts and detection of health risks, offering real-time insights into public perceptions and changing situations on the ground. Our findings highlight the value of social media as a complementary tool for real-time surveillance of disaster situations and public health response. The insights from social media can support timely action by public health officials, emergency services, nonprofits, and volunteers to plan and act efficiently during disaster response and relief. Future research should focus on extracting granular health-related information from social media data to enhance disaster response effectiveness and support for affected communities.

气候变化增加了自然灾害发生的频率和严重程度，在灾害发生期间和之后对公众的身心健康构成重大风险。与此同时，人们对社交媒体提供灾难如何展开的实时信息的依赖也在增加。我们使用Arksey和O 'Malley框架进行了范围审查，以确定如何使用2010年至2024年来自社交媒体平台的众包数据来了解美国气候变化驱动的自然灾害期间的健康结果。我们使用人机协作的跨学科多方法方法回顾了34篇同行评议的文章。两个关键的研究问题指导了这次审查：(1)在气候相关灾害期间，如何利用社交媒体为公共卫生风险预警系统提供信息？(2)在此类灾害事件中，社交媒体指标是否反映了不同人群和地理区域之间健康结果的差异？范围审查揭示了社会媒体价值已得到证明的四个主要专题领域：健康问题、受影响人口、灾害影响和应对以及环境因素。社交媒体平台经常支持早期预警工作和健康风险检测，提供对公众看法和实地情况变化的实时洞察。我们的研究结果强调了社交媒体作为实时监测灾害情况和公共卫生反应的补充工具的价值。来自社交媒体的见解可以支持公共卫生官员、应急服务机构、非营利组织和志愿者及时采取行动，在灾难响应和救济期间有效地制定计划和采取行动。未来的研究应侧重于从社交媒体数据中提取与健康相关的详细信息，以提高救灾效率和对受影响社区的支持。

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引用次数: 0

Potential effect of co-exposure to Per- and polyfluoroalkyl substances on the risk of insomnia 共接触全氟烷基和多氟烷基物质对失眠风险的潜在影响

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-20 DOI: 10.1016/j.heha.2025.100163

Ziyi Zhang , Nan Li , Zeping Yang , Ming Jin , Xiaojing Liu , Yanyan Zhang , Nan Lin , Zhiwen Li , Lili Zhuang , Hongchu Bao , Ran Zhao , Bin Wang

Per- and polyfluoroalkyl substances (PFASs) can interfere with the endocrine and central nervous systems, and may further disrupt sleep quality. To address this concern, we investigated the association between the whole-blood levels of several PFASs and insomnia. A total of 394 female adults were recruited and 30 PFASs were measured. Multivariate logistic regression models were employed to test the individual associations between the level of each component and insomnia. Quantile-based g-computation and Bayesian kernel machine regression models were used to estimate whether co-exposure to PFASs increased the risk of insomnia. The individual exposure analyses revealed that the levels of perfluorodecanoic acid [odds ratio (OR) = 1.22, 95 % confidence interval (CI): 1.03, 1.45)], perfluoroundecanoic acid [OR = 1.59 (95 % CI: 1.02, 2.47)], perfluorononanoic acid [OR = 2.20 (95 % CI: 1.15, 4.21)], and 6:2 chlorinated polyfluorinated ether sulfonate [OR for quartile 2 (Q2) = 2.07 (95 % CI: 1.10, 3.88), OR for Q4 = 2.27 (95 % CI: 1.17, 4.42)] were positively associated with the risk of insomnia. Our findings nonetheless suggest that reducing exposure to such substances would probably lower the risk of insomnia in adults.

全氟和多氟烷基物质（PFASs）会干扰内分泌和中枢神经系统，并可能进一步破坏睡眠质量。为了解决这一问题，我们调查了几种PFASs的全血水平与失眠之间的关系。总共招募了394名女性成年人，测量了30个PFASs。采用多元逻辑回归模型检验各成分水平与失眠之间的个体关联。使用基于分位数的g计算和贝叶斯核机回归模型来估计共同暴露于PFASs是否会增加失眠的风险。个人接触分析表明perfluorodecanoic酸的水平(比值比(或)= 1.22,95%可信区间(CI): 1.03, 1.45)], perfluoroundecanoic酸(或= 1.59(95%置信区间CI: 1.02, 2.47)], perfluorononanoic酸(或= 2.20(95%置信区间CI: 1.15, 4.21)],和以氯化polyfluorinated醚磺酸盐(或四分位数2 (Q2) = 2.07(95%置信区间CI: 1.10, 3.88),或第四季度= 2.27(95%置信区间CI: 1.17, 4.42)]与失眠的风险呈正相关。尽管如此，我们的研究结果表明，减少接触这些物质可能会降低成年人失眠的风险。

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引用次数: 0

Human internal exposure to polycyclic aromatic hydrocarbon: A global review of monohydroxylated metabolites and associated health risks 人体内部暴露于多环芳烃：单羟基化代谢物及其相关健康风险的全球综述

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-19 DOI: 10.1016/j.heha.2025.100165

Senyuan Huang , Lei Fang , Shengbing Yu , Chaoyang Long , Yingxin Yu

Anthropogenic activities have exacerbated the environmental contamination of polycyclic aromatic hydrocarbons (PAHs) with adverse health effects on human health. In response, various human biomonitoring utilizing urine, hair, nails, breast milk or blood have been established to assess PAH exposure levels as alternatives to external exposure assessment, with monohydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) used as biomarkers. However, comprehensive summaries of internal exposure levels of OH-PAHs remain scarce, except for the urinary OH-PAHs in children. In this review, available studies on OH-PAHs in human biomatrices were synthesized to estimate the internal levels of PAH exposure along with health risks in populations worldwide. While the composition profiles of urinary OH-PAHs among countries were similar with OHNap as the predominant metabolite, variations among different human biomatrices were observed. Influencing factors such as gender, age, living environment, smoking, season, and occupation could affect OH-PAH levels. The carcinogenic risk posed by PAH exposure warranted greater attention than non-carcinogenic risk. Currently, significant gaps persist in human biomonitoring in South America and Africa particularly. Future research should conduct human biomonitoring of OH-PAHs frequently and refine health risk assessment to inform evidence-based regulatory decisions.

人类活动加剧了多环芳烃（PAHs）对环境的污染，对人类健康产生不利影响。为此，已经建立了各种人体生物监测方法，利用尿液、头发、指甲、母乳或血液来评估多环芳烃暴露水平，以单羟基化多环芳烃（OH-PAHs）作为生物标志物，作为外部暴露评估的替代方法。然而，除了儿童尿液中的OH-PAHs外，关于OH-PAHs内部暴露水平的综合总结仍然很少。在这篇综述中，对人类生物基质中羟基多环芳烃的现有研究进行了综合，以估计全球人群中多环芳烃暴露的内部水平以及健康风险。虽然各国尿液中OH-PAHs的组成特征相似，OHNap是主要代谢物，但不同人类生物基质之间存在差异。性别、年龄、生活环境、吸烟、季节、职业等影响因素均可影响OH-PAH水平。多环芳烃暴露的致癌风险比非致癌风险更值得关注。目前，特别是在南美洲和非洲，人体生物监测方面仍然存在重大差距。未来的研究应频繁开展人体对OH-PAHs的生物监测，完善健康风险评估，为基于证据的监管决策提供信息。

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引用次数: 0

Ecological risk assessment of dieldrin presence in soil and vegetables: a case study in Indo-Gangetic region, Gaya, India 狄氏剂在土壤和蔬菜中存在的生态风险评估：以印度伽耶印度-恒河地区为例

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-19 DOI: 10.1016/j.heha.2025.100164

Akriti Ashesh, Ningombam Linthoingambi Devi

Contamination of dieldrin in soil and vegetables are reported even after its regulatory ban in many countries. However, monitoring of such persistent organic pollutants is not consistent in India. Still regional-level studies and report on dieldrin contamination are limited. Gaya Ji, being the 2nd largest economic district of the 3rd most populous state, Bihar, in India, is chosen for monitoring regional dieldrin contamination levels in soil and vegetable grown in the area. The present study monitored contamination of dieldrin in soil-vegetable samples to assess the health and ecological risk related to its exposure. 53 soil and vegetable samples were collected from Gaya district. Dieldrin was extracted with soxhlet extraction unit and estimated by Gas Chromatography Mass Spectrometry Detector (GCMSD). 2,4,5,6-tetrachloro-m-xylene (TCmX) was used as a surrogate standard, which yielded 71.94% - 89.91% recovery. Dieldrin concentration in soil and vegetable ranged from 0.04–1.33μg/g and 0.0019–0.97μg/g, respectively. 95.75% of the contaminated soil samples showed higher concentration than limit set by the Dutch Serious Risk Concentration (SRC) in 1976. 93.75% of vegetable samples showed contamination above the MRLs set by EU/WHO in 1994. Human risk assessment indicated that children (5–11 years) and adults (≥20 years) were the most vulnerable to cancer risk due to dieldrin exposure via dermal route. Adults and toddlers (7 months- 4 years) were the most vulnerable to the non-cancerous risk due to dieldrin exposure via ingestion route. Ecological risk assessment carried for earthworms, rats, and birds based on their modeled toxicity values given by Agriculture & Environment Research Unit (AERU) at the University of Hertfordshire, UK in 2016. The assessment indicated moderate risk for 47.82% soil and 12.5% vegetable samples. The findings of the present research reveal serious contamination and risks related to dieldrin exposure. Thus, demands regular monitoring and remediation studies to reduce its persistence in the environment.

即使在许多国家禁用狄氏剂后，土壤和蔬菜中仍有狄氏剂污染的报道。然而，对这种持久性有机污染物的监测在印度并不一致。然而，区域一级关于狄氏剂污染的研究和报告仍然有限。Gaya Ji是印度第三人口大国比哈尔邦的第二大经济区，被选中监测该地区土壤和蔬菜中的狄氏剂污染水平。本研究监测了土壤-蔬菜样品中狄氏剂的污染情况，以评估与接触狄氏剂有关的健康和生态风险。在Gaya地区采集了53份土壤和蔬菜样本。用索氏提取装置提取狄氏剂，用气相色谱质谱检测器（GCMSD）测定狄氏剂含量。以2,4,5,6-四氯间二甲苯（TCmX）为替代标准品，回收率为71.94% ~ 89.91%。土壤和蔬菜中狄氏剂浓度分别为0.04 ~ 1.33μg和0.0019 ~ 0.97μg。95.75%的污染土壤样品浓度高于荷兰1976年规定的严重危险浓度（SRC）限值。93.75%的蔬菜样本污染水平高于欧盟/世界卫生组织1994年制定的最高限量。人类风险评估表明，儿童（5-11岁）和成人（≥20岁）最容易因皮肤途径接触狄氏剂而发生癌症风险。成人和幼儿（7个月- 4岁）最容易因摄入狄氏剂而发生非癌性风险。根据2016年英国赫特福德大学农业与环境研究中心（AERU）给出的模拟毒性值，对蚯蚓、老鼠和鸟类进行了生态风险评估。47.82%的土壤样品和12.5%的蔬菜样品存在中度风险。目前的研究结果揭示了与狄氏剂接触有关的严重污染和风险。因此，需要定期监测和补救研究，以减少其在环境中的持久性。

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引用次数: 0

NLRP3 inflammasome inhibition attenuates liver injury and dysfunction induced by noise exposure in rats 抑制NLRP3炎性体可减轻大鼠噪声暴露引起的肝损伤和功能障碍

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-19 DOI: 10.1016/j.heha.2025.100166

Yongke He , Yixian Ren , Hangqian Zhang , Runping Liang , Kangyong Wu , Zhenming Zheng , Zhou Li , Wanmin Liang , Liping Zhou , Jiu Chen , Guanhao Guo , Shihua Wu , Xueji Yang , Weijie Ling , Jiaming Guo , Yanmei Ruan , Wenchong Tan , Bin Wang , Zhi Wang

Noise, a significant environmental stressor, has been demonstrated to induce dysregulated glucose and lipid metabolism. However, the precise molecular mechanisms driving liver dysfunction in noise-induced dysregulated glucose and lipid metabolism remain incompletely elucidated. Recent studies have underscored the pivotal role of the NLRP3 (Nod-like receptor protein 3) inflammasome in the context of liver pathology. To this end, a noise-exposure rat model was established (100 dB, 4 h/day for 30 days) to investigate whether the NLRP3 inflammasome mediates noise-caused hepatic injury and dysfunction. Exposure to noise resulted in significant alterations to liver architecture and dysfunction in rats. Furthermore, we found that noise triggered assembly and activation of the NLRP3 inflammasome, effects that were suppressed by the NLRP3 inhibitor MCC950. Such inhibition thereby attenuated liver damage and improved hepatic function. In conclusion, our findings indicate that noise-induced NLRP3 inflammasome activation promotes hepatic inflammation, contributing to liver injury and dysregulation of glucose and lipid metabolism. These results provide new mechanistic insights into the pathogenesis of noise-induced liver damage and dysfunction.

噪音是一种重要的环境应激源，已被证明可诱导糖脂代谢失调。然而，在噪声诱导的糖脂代谢失调中驱动肝功能障碍的精确分子机制仍未完全阐明。最近的研究强调了NLRP3 （nod样受体蛋白3）炎症小体在肝脏病理中的关键作用。为此，我们建立噪声暴露大鼠模型（100 dB，每天4小时，持续30天），研究NLRP3炎性体是否介导噪声引起的肝损伤和功能障碍。暴露于噪音导致大鼠肝脏结构和功能障碍的显著改变。此外，我们发现噪音触发NLRP3炎性体的组装和激活，而这种作用被NLRP3抑制剂MCC950所抑制。这种抑制减轻了肝损伤，改善了肝功能。总之，我们的研究结果表明，噪声诱导的NLRP3炎性小体激活可促进肝脏炎症，导致肝损伤和糖脂代谢失调。这些结果为噪声引起的肝损伤和功能障碍的发病机制提供了新的见解。

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引用次数: 0

HEHA editorial - Perspectives on climate change and health HEHA社论-对气候变化和健康的看法

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 DOI: 10.1016/j.heha.2025.100150

Shao Lin , Michael S. Bloom , Guang-Hui Dong , Samantha Friedman , Wenjun Ma , Di Wu , Xiaobo Romeiko , Jennifer Manganello , Xiaojun Yuan , DeeDee Bennett Gayle

引用次数: 0

Exposure to organophosphate esters (OPEs) of children (1-12y) in Guangxi, China: Predictors evaluation by machine learning 中国广西儿童（1-12岁）暴露于有机磷酸酯（OPEs）：机器学习预测评估

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 DOI: 10.1016/j.heha.2025.100159

Na Li , Ting Fan Leung , Linwei Tian , Huachang Hong , Wen-Jing Deng

Organophosphate esters (OPEs), widely employed as flame-retardants and plasticizers, have been linked to adverse health outcomes in children. This study evaluated the predictors of OPE exposure in children aged 1 to 12 years in Guangxi, China. Eleven OPEs were detected in a cohort of 84 children and their parents’ urine, with geometric mean (GM) levels ranging from 0.11 ng/g_crea (tri-n-propyl phosphate, TPP) to 25.93 ng/g_crea (tris(2,3-dichloropropyl) phosphate, TDCPP) in children, and from 0.04 ng/g_crea (triphenyl phosphate, TPHP) to 18.71 ng/g_crea (TDCPP) in parents. These findings are consistent with values reported in several large-scale national urinary biomonitoring studies on OPEs. Significant positive correlations among most target OPEs and no significant gender and age differences in children’s urine were found. The eXtreme Gradient Boosting (XGBoost) coupled with Shapley Additive explanations (SHAP), was employed to analyse the importance of 93 variables from the questionnaire and interpret the levels of OPEs in children’s urine. Models for six OPEs were constructed, revealing that daily use of fans affected the levels of five OPEs. Additionally, egg consumption and the number of family members were associated with higher levels of TPP/TCEP, and CDP/TEHP, respectively. There is a need to conduct more precise quantitative assessments of OPE exposure routes.

广泛用作阻燃剂和增塑剂的有机磷酸酯（OPEs）与儿童的不良健康结果有关。本研究评估了中国广西1至12岁儿童暴露于OPE的预测因素。在84名儿童及其父母的尿液中检测到11种OPEs，儿童的几何平均（GM）水平从0.11 ng/gcrea（三正丙基磷酸，TPP）到25.93 ng/gcrea（三（2,3-二氯丙基）磷酸，TDCPP）到0.04 ng/gcrea（三苯基磷酸，TPHP）到18.71 ng/gcrea（三苯基磷酸，TDCPP）。这些发现与几项大规模国家泌尿系统生物监测研究报告的结果一致。大多数目标OPEs之间存在显著的正相关，儿童尿液中没有显著的性别和年龄差异。采用极限梯度提升法（XGBoost）结合Shapley加性解释法（SHAP）分析问卷中93个变量的重要性，并解释儿童尿液中OPEs的水平。构建了6个OPEs的模型，揭示了风机的日常使用影响了5个OPEs的水平。此外，鸡蛋摄入量和家庭成员数量分别与较高水平的TPP/TCEP和CDP/TEHP有关。有必要对接触外伤性脑炎的途径进行更精确的定量评估。

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引用次数: 0

Effects of occupational exposure factors interacting with NLRP3 gene polymorphisms on mild cognitive impairment: A cross-sectional study of workers in an aluminum electrolysis production environment 职业暴露因素与NLRP3基因多态性相互作用对轻度认知障碍的影响：铝电解生产环境中工人的横断面研究

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 DOI: 10.1016/j.heha.2025.100144

Youxing Li , Yaqin Pang , Wenxue Li , Dongshun Chen , Caiping Zhang , Yufang Cen , Junhong Wei , Rongqing Xiao , Wenlian Rao , Yinxia Lin , Ahmad Razali Ishak , Mohd Shukri Bin Mohd Aris , Guangzi Qi

Mild cognitive impairment (MCI) is an early stage of Alzheimer's disease and is the result of interactions between environmental and genetic factors. However, their impact on aluminum workers is not yet clear. This study aimed to explore the interaction between occupational exposure and NLRP3 gene polymorphisms on the odds of MCI among aluminum production workers. We assessed the cognitive function of 478 workers in a factory in Guangxi, China, and identified two main occupational exposure factors: principal component 1 (PC1: noise, high temperature, carbon monoxide, sulfur dioxide, nitrogen oxides) and principal component 2 (PC2: aluminum oxide dust, magnetic field, fluoride, manganese dioxide). Genotyping of polymorphisms in the NLRP3 gene (rs10754558, rs10925027, rs3806265, rs4612666) was performed. The results of the analysis showed that high PC2 exposure significantly increased the odds of MCI [OR (95 % CI): 1.99 (1.36, 2.91)], and the rs10754558 G/C genotype was independently associated with MCI [OR (95 % CI): 1.56 (1.05, 2.33)]. PC2 interacted with rs3806265 C/T [OR (95 % CI):2.13 (1.16, 3.92)] and rs4612666 C/T [OR (95 % CI): 2.84 (1.19,6.81)], further increasing the odds of MCI. These findings suggest that alumina dust, magnetic fields, fluoride, and manganese dioxide are the main occupational hazards factors for MCI. rs10754558 G/C is an independent susceptibility genotype for MCI, while rs3806265 C/T and rs4612666 C/T are environmental susceptibility genotypes for MCI. This study emphasizes that reducing occupational exposure and screening for susceptibility genes can provide a basis for targeted interventions to reduce the odds of MCI in this population.

轻度认知障碍（MCI）是阿尔茨海默病的早期阶段，是环境和遗传因素相互作用的结果。然而，它们对铝业工人的影响尚不清楚。本研究旨在探讨职业暴露与NLRP3基因多态性对铝生产工人MCI患病几率的相互作用。我们评估了中国广西某工厂478名工人的认知功能，并确定了两个主要的职业暴露因素：主成分1 （PC1：噪音、高温、一氧化碳、二氧化硫、氮氧化物）和主成分2 （PC2：氧化铝粉尘、磁场、氟化物、二氧化锰）。对NLRP3基因（rs10754558、rs10925027、rs3806265、rs4612666）的多态性进行基因分型。分析结果显示，高PC2暴露显著增加MCI的发生几率[OR (95% CI): 1.99 (1.36, 2.91)]， rs10754558 G/C基因型与MCI独立相关[OR (95% CI): 1.56(1.05, 2.33)]。PC2与rs3806265 C/T [OR (95% CI):2.13(1.16, 3.92)]和rs4612666 C/T [OR (95% CI): 2.84(1.19,6.81)]相互作用，进一步增加MCI的发生几率。综上所述，氧化铝粉尘、磁场、氟化物和二氧化锰是MCI的主要职业危害因素。rs10754558 G/C为MCI的独立易感基因型，rs3806265 C/T和rs4612666 C/T为MCI的环境易感基因型。本研究强调，减少职业暴露和筛查易感基因可以为有针对性的干预提供基础，以降低这一人群MCI的发生率。

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