托伐非尼对携带BRAF融合的低级别胶质瘤有效

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2023-12-11 DOI:10.1038/s41571-023-00845-z
Peter Sidaway
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引用次数: 0

摘要

2023 年 3 月,美国食品及药物管理局批准了达拉非尼加曲美替尼,为 BRAFV600E 突变低级别胶质瘤(LGG)患者提供了一种亟需的靶向治疗选择。然而,作为 I 型激酶抑制剂,达拉非尼对 BRAF 融合患者无效,包括 KIAA1549-BRAF。现在,II 期 FIREFLY-1 试验的数据表明,II 型 RAF 抑制剂托伐非尼对携带 BRAF 融合或 BRAFV600E 突变的难治性 LGG 儿科患者(1-24 岁)具有疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Tovorafenib effective against low-grade gliomas harbouring BRAF fusions
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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