金藤素可上调免疫抑制大鼠细胞因子的产生以及与自然杀伤细胞活性相关的 NKp30、NKp44 和 NKp44 的表达

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2023-12-12 DOI:10.1016/j.jgr.2023.12.001

BaiCheng Chen , Ajay Vijayakumar , Chul Park , Ulsoo Choi , Seung-Yeol Nah , Jong-Hoon Kim

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摘要

这项研究的目的是通过环磷酰胺（CY）诱导的免疫抑制动物中自然杀伤细胞（NK细胞）的活性，来评估金藤素作为一种免疫增强剂的潜力。研究结果表明，金藤素可减轻环磷酰胺诱导的免疫抑制，并可调节 NK 细胞的活性，从而增强免疫力。

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Gintonin upregulates cytokine production and expression of NKp30, NKp44 and NKp44 related to natural killer cell activity on immunosuppressive rat

The objective of the study is to estimate the potential of gintonin, as an immune enhancing agent through natural killer cell (NK cell) activity in cyclophosphamide (CY)-induced immunosuppressive animals. Accumulated results reveals that, gintonin attenuated CY-induced immunosuppression and it might modulate NK cell activity to boost the immunity.

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.