O. L. Boriskina, V. N. Tsigan, A. S. Rumyantsev, A. A. Yakovenko
{"title":"晚期糖化终末产物在慢性肾脏病患者肌少症中的作用","authors":"O. L. Boriskina, V. N. Tsigan, A. S. Rumyantsev, A. A. Yakovenko","doi":"10.36485/1561-6274-2023-27-4-43-51","DOIUrl":null,"url":null,"abstract":"The accumulation of glycation end products (AGEs) is closely related to chronic inflammation, oxidative stress and can affect muscle function. An increase of the concentration of AGEs in the serum can be observed in patients already at the initial stages of the formation of chronic kidney disease (CKD). At the same time, there is no need for a violation of carbohydrate tolerance or diabetes mellitus. Sarcopenia is one of the complications of CKD. Its development in CKD can be considered not only as a result of endogenous intoxication, but also as one of the variants of premature aging. This literature review is devoted to the analysis of the mechanisms of the influence of AGEs on the occurrence and progression of sarcopenia in CKD.","PeriodicalId":19089,"journal":{"name":"Nephrology (Saint-Petersburg)","volume":"110 22","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of advanced glycation end products in sarcopenia in CKD patients\",\"authors\":\"O. L. Boriskina, V. N. Tsigan, A. S. Rumyantsev, A. A. Yakovenko\",\"doi\":\"10.36485/1561-6274-2023-27-4-43-51\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The accumulation of glycation end products (AGEs) is closely related to chronic inflammation, oxidative stress and can affect muscle function. An increase of the concentration of AGEs in the serum can be observed in patients already at the initial stages of the formation of chronic kidney disease (CKD). At the same time, there is no need for a violation of carbohydrate tolerance or diabetes mellitus. Sarcopenia is one of the complications of CKD. Its development in CKD can be considered not only as a result of endogenous intoxication, but also as one of the variants of premature aging. This literature review is devoted to the analysis of the mechanisms of the influence of AGEs on the occurrence and progression of sarcopenia in CKD.\",\"PeriodicalId\":19089,\"journal\":{\"name\":\"Nephrology (Saint-Petersburg)\",\"volume\":\"110 22\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nephrology (Saint-Petersburg)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36485/1561-6274-2023-27-4-43-51\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nephrology (Saint-Petersburg)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36485/1561-6274-2023-27-4-43-51","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The role of advanced glycation end products in sarcopenia in CKD patients
The accumulation of glycation end products (AGEs) is closely related to chronic inflammation, oxidative stress and can affect muscle function. An increase of the concentration of AGEs in the serum can be observed in patients already at the initial stages of the formation of chronic kidney disease (CKD). At the same time, there is no need for a violation of carbohydrate tolerance or diabetes mellitus. Sarcopenia is one of the complications of CKD. Its development in CKD can be considered not only as a result of endogenous intoxication, but also as one of the variants of premature aging. This literature review is devoted to the analysis of the mechanisms of the influence of AGEs on the occurrence and progression of sarcopenia in CKD.