Rab11 家族互作蛋白 4 在子痫前期发病中的生物学功能及其内在机制

IF 2.9 4区 医学 Q1 Medicine Journal of biomedical nanotechnology Pub Date : 2023-12-01 DOI:10.1166/jbn.2023.3745
Shanshan Yang, Guixia Sun, Yanxia Zhang
{"title":"Rab11 家族互作蛋白 4 在子痫前期发病中的生物学功能及其内在机制","authors":"Shanshan Yang, Guixia Sun, Yanxia Zhang","doi":"10.1166/jbn.2023.3745","DOIUrl":null,"url":null,"abstract":"To elucidate the biological function of Rab11-FIP4 in the development of preeclampsia, as well as its clinical significance and underlying mechanism. Relative levels of Rab11-FIP4, IL-6 and TNF-α in placental tissues of PE pregnant women and healthy pregnant women were\n detected by qRT-PCR. The correlation between Rab11-FIP4 and IL-6 or TNF-α was assessed by Pearson correlation test. After constructing overexpression lentivirus targeting Rab11-FIP4, its influences on biological characteristics of HTR-8/SVneo cells and expression levels of inflammatory\n cytokines were examined. Rab11-FIP4 was highly expressed in placental tissues of PE pregnant women. Overexpression of Rab11-FIP4 enhanced migratory and invasive capacities of trophoblasts, and upregulated inflammatory proteins. Rab11-FIP4 aggravates the development of PE by upregulating inflammatory\n proteins, and stimulating migratory and invasive capacities of trophoblasts.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":" 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biological Function of Rab11-Family Interacting Protein 4 in the Development of Preeclampsia and Their Underlying Mechanism\",\"authors\":\"Shanshan Yang, Guixia Sun, Yanxia Zhang\",\"doi\":\"10.1166/jbn.2023.3745\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To elucidate the biological function of Rab11-FIP4 in the development of preeclampsia, as well as its clinical significance and underlying mechanism. Relative levels of Rab11-FIP4, IL-6 and TNF-α in placental tissues of PE pregnant women and healthy pregnant women were\\n detected by qRT-PCR. The correlation between Rab11-FIP4 and IL-6 or TNF-α was assessed by Pearson correlation test. After constructing overexpression lentivirus targeting Rab11-FIP4, its influences on biological characteristics of HTR-8/SVneo cells and expression levels of inflammatory\\n cytokines were examined. Rab11-FIP4 was highly expressed in placental tissues of PE pregnant women. Overexpression of Rab11-FIP4 enhanced migratory and invasive capacities of trophoblasts, and upregulated inflammatory proteins. Rab11-FIP4 aggravates the development of PE by upregulating inflammatory\\n proteins, and stimulating migratory and invasive capacities of trophoblasts.\",\"PeriodicalId\":15260,\"journal\":{\"name\":\"Journal of biomedical nanotechnology\",\"volume\":\" 1\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biomedical nanotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1166/jbn.2023.3745\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical nanotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1166/jbn.2023.3745","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

阐明Rab11-FIP4在子痫前期发生发展中的生物学功能及其临床意义和机制。采用qRT-PCR检测PE孕妇与健康孕妇胎盘组织中Rab11-FIP4、IL-6、TNF-α的相对水平。采用Pearson相关检验评估Rab11-FIP4与IL-6或TNF-α的相关性。构建Rab11-FIP4过表达慢病毒后,检测其对HTR-8/SVneo细胞生物学特性及炎症因子表达水平的影响。Rab11-FIP4在PE孕妇胎盘组织中高表达。Rab11-FIP4的过表达增强了滋养细胞的迁移和侵袭能力,上调了炎症蛋白。Rab11-FIP4通过上调炎症蛋白,刺激滋养细胞的迁移和侵袭能力,从而加剧PE的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Biological Function of Rab11-Family Interacting Protein 4 in the Development of Preeclampsia and Their Underlying Mechanism
To elucidate the biological function of Rab11-FIP4 in the development of preeclampsia, as well as its clinical significance and underlying mechanism. Relative levels of Rab11-FIP4, IL-6 and TNF-α in placental tissues of PE pregnant women and healthy pregnant women were detected by qRT-PCR. The correlation between Rab11-FIP4 and IL-6 or TNF-α was assessed by Pearson correlation test. After constructing overexpression lentivirus targeting Rab11-FIP4, its influences on biological characteristics of HTR-8/SVneo cells and expression levels of inflammatory cytokines were examined. Rab11-FIP4 was highly expressed in placental tissues of PE pregnant women. Overexpression of Rab11-FIP4 enhanced migratory and invasive capacities of trophoblasts, and upregulated inflammatory proteins. Rab11-FIP4 aggravates the development of PE by upregulating inflammatory proteins, and stimulating migratory and invasive capacities of trophoblasts.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
期刊最新文献
Mequinol-Loaded Nano Clay Drug Carriers in a Gelatin Hydrogel for Wound Healing: An Antiinflammatory and Antioxidant Treatment Modality Resveratrol Inhibited Nanoparticles Stromal Interaction Molecule 2 in Regulating miR-20b-5p Signaling Pathway to Improve Mitochondrial Function During Myocardial Ischemia-Reperfusion Injury A Hierarchically Micro- and Nanofibrous Hybrid Hydrogel Derived from Decellularized Skin Matrix with High Bioactivity and Tunable Mechanical Properties for Accelerated Wound Healing Sport Medicine Principles Augment Healing Response in Spinal Cord Injury in a Rat Model Treated with a Curcumin-Loaded Nanocomposite Hydrogel Polyacrylic Acid-Modified Superparamagnetic Iron Oxide Nanoparticles Differentiate Between Hyperplastic and Metastatic Breast Cancer Lymph Nodes
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1