内皮细胞在自身免疫性风湿病中的作用

IF 2.5 Q2 PHYSIOLOGY Current Opinion in Physiology Pub Date : 2023-12-01 DOI:10.1016/j.cophys.2023.100732
Medha Kanitkar, Christopher P Denton
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引用次数: 0

摘要

血管病变是自身免疫性风湿病的一个共同特征,有大量证据表明,内皮细胞功能障碍在这组具有挑战性的疾病的发病机制和临床表现中起着重要作用。内皮细胞(EC)是损伤的目标,由于其在血管稳态中发挥着重要的功能作用,因此具有重大影响。此外,人们逐渐认识到内皮细胞是其他细胞类型的重要调节器,并能分化成其他相关细胞类型,这与内皮细胞有直接关系。本文对这些方面进行了综述,并重点分析了最近发表的有关心肌细胞在自身免疫性风湿病的发生、发展和治疗中的重要性的证据。还将综述适应性免疫系统和先天性免疫系统在造成内皮细胞损伤(包括抗内皮细胞自身抗体)方面的潜在作用。还将综述了解内皮细胞如何分化为间充质系的最新进展,以及在愈合或组织修复中的生理作用与获得性结缔组织疾病中的功能障碍反应之间的相互作用。
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The role of endothelial cells in autoimmune rheumatic disease

Vasculopathy is a generic feature of autoimmune rheumatic disease and there is substantial evidence that endothelial cell dysfunction has a role in pathogenesis and clinical manifestations of this challenging group of diseases. Endothelial cells (EC) are a target for injury and through their essential functional role in vascular homoeostasis, this has significant impact. In addition, the emerging recognition that EC are important regulators of other cell types and can differentiate into other relevant cell types has direct relevance. These aspects are reviewed with a focus on recent published evidence regarding the importance of EC in development, progression and treatment of autoimmune rheumatic disease. The potential role of the adaptive and innate immune system in causing endothelial cell damage, including anti-endothelial cell autoantibodies, will be reviewed. Recent advances in understanding how EC may differentiate into mesenchymal lineages and the interplay between physiological roles in healing or tissue repair and dysfunctional responses in acquired connective tissue disease will be reviewed.

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来源期刊
Current Opinion in Physiology
Current Opinion in Physiology Medicine-Physiology (medical)
CiteScore
5.80
自引率
0.00%
发文量
52
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