纳米氧化石墨烯和洗必泰复合膜用作牙周病功能分级膜表层的潜力

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2023-12-16 DOI:10.1007/s10856-023-06767-7
Syed Saad Bin Qasim, Jasim Ahmed, Maribasappa Karched, Adel Al-Asfour
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引用次数: 0

摘要

薄膜已被用于治疗牙周缺损,并在引导骨再生应用中发挥着重要作用。纳米氧化石墨烯因其生物力学特性已被用于组织工程。其与羟基磷灰石和壳聚糖的复合配方可控制降解,有助于成为功能分级膜表层的一部分。本研究旨在利用溶剂浇铸技术合成壳聚糖以及纳米氧化石墨烯、羟基磷灰石和洗必泰双葡萄糖酸盐的复合配方,并对膜的物理化学、机械、水蒸气透过率(阻隔性)、降解和抗菌潜力进行表征。共制备了四种不同的膜(CH、CCG、3511 和 3322)。结果表明,羟基磷灰石、壳聚糖和纳米氧化石墨因分子间和分子内氢键而产生化学作用。3322 的拉伸强度(33.72 ± 6.3 兆帕)和 3511 的拉伸强度(32.06 ± 5.4 兆帕)高于 CH(27.46 ± 9.6 兆帕)。CCG 的水蒸气透过率最低(0.23 ± 0.01 g/h.m2),但第 14 天的失重率最高(76.6%)。3511 在 72 小时后显示出更高的药物释放率(55.6%)。 所有膜都能显著抑制生物膜的生长。3511 对放线菌有完全的抑制作用。对合成膜进行的详细表征显示,3511 复合膜被证明是一种很有前途的候选材料,可用作牙周病变引导骨再生膜的表层。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The potential of nano graphene oxide and chlorhexidine composite membranes for use as a surface layer in functionally graded membranes for periodontal lesions

Membranes have been used for treating periodontal defects and play a crucial role in guided bone regeneration applications. Nano graphene oxide have been exploited in tissue engineering due to its biomechanical properties. Its composite formulations with hydroxyapatite and chitosan with controlled degradation could aid in becoming part of a surface layer in a functionally graded membrane. The aim of the study was to synthesize chitosan and composite formulations of nano graphene oxide, hydroxyapatite and chlorhexidine digluconate using solvent casting technique and to characterize the physiochemical, mechanical, water vapor transmission rate (barrier), degradation and antimicrobial potential of the membranes. Altogether four different membranes were prepared (CH, CCG, 3511 and 3322). Results revealed the chemical interactions of hydroxyapatite, chitosan and nanographene oxide due to inter and intra molecular hydrogen bonding. The tensile strength of 3322 (33.72 ± 6.3 MPa) and 3511 (32.06 ± 5.4 MPa) was higher than CH (27.46 ± 9.6 MPa). CCG showed the lowest water vapor transmission rate (0.23 ± 0.01 g/h.m2) but the highest weight loss at day 14 (76.6 %). 3511 showed a higher drug release after 72 h (55.6 %) Significant biofilm growth inhibition was observed for all membranes. 3511 showed complete inhibition against A. actinomycetemcomitans. Detailed characterization of the synthesized membranes revealed that 3511 composite membrane proved to be a promising candidate for use as a surface layer of membranes for guided bone regeneration of periodontal lesions.

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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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