进入折叠:了解 aPKC 膜动力学的进展

IF 4.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemical Journal Pub Date : 2023-12-20 DOI:10.1042/bcj20230390
Cobbaut, Mathias, Parker, Peter J., McDonald, Neil Q.
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引用次数: 0

摘要

非典型蛋白激酶 C(aPKC)是蛋白激酶 PKC 家族的一部分,之所以是非典型的,是因为它们对典型 PKC 激活剂二酰甘油(DAG)和 Ca2+ 没有反应。它们是极化细胞组织的核心,在几种癌症中都出现了失调。将 aPKC 招募到质膜区是它们遇到与极化功能相关的底物的关键。然而,与其他 PKCs 不同的是,非典型 PKCs 被招募到质膜区的机制直到最近仍不为人所知。在此,我们将 aPKC 纳入研究范围,总结了最近有关 aPKC 直接招募到膜上的报道,深入分析了看似不一致的发现,并将其与现有文献进行了整合。
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Into the fold: advances in understanding aPKC membrane dynamics
Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don't respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+. They are central to the organization of polarized cells and are deregulated in several cancers. aPKC recruitment to the plasma membrane compartment is crucial to their encounter with substrates associated with polarizing functions. However, in contrast with other PKCs, the mechanism by which atypical PKCs are recruited there has remained elusive until recently. Here, we bring aPKC into the fold, summarizing recent reports on the direct recruitment of aPKC to membranes, providing insight into seemingly discrepant findings and integrating them with existing literature.
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来源期刊
Biochemical Journal
Biochemical Journal 生物-生化与分子生物学
CiteScore
8.00
自引率
0.00%
发文量
255
审稿时长
1 months
期刊介绍: Exploring the molecular mechanisms that underpin key biological processes, the Biochemical Journal is a leading bioscience journal publishing high-impact scientific research papers and reviews on the latest advances and new mechanistic concepts in the fields of biochemistry, cellular biosciences and molecular biology. The Journal and its Editorial Board are committed to publishing work that provides a significant advance to current understanding or mechanistic insights; studies that go beyond observational work using in vitro and/or in vivo approaches are welcomed. Painless publishing: All papers undergo a rigorous peer review process; however, the Editorial Board is committed to ensuring that, if revisions are recommended, extra experiments not necessary to the paper will not be asked for. Areas covered in the journal include: Cell biology Chemical biology Energy processes Gene expression and regulation Mechanisms of disease Metabolism Molecular structure and function Plant biology Signalling
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