Teucrium polium L.(灯心草科)水醇提取物对百草枯引起的肺纤维化的潜在保护作用:大鼠实验研究。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-09-01 DOI:10.22038/AJP.2023.22121
Shahrzad Molavinia, Mehdi Goudarzi, Mohammad Ebrahim Azemi, Zahra Basir, Zahra Nazari Khorasgani, Mohammad Reza Rashidi Nooshabadi, Rezvan Ebrahimi, Mohammad Javad Khodayar
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引用次数: 0

摘要

目的:百草枯(PQ)是一种剧毒除草剂,可导致肺纤维化(PF),目前尚无特效解毒剂。柚木(Teucrium polium L.)是一种具有抗氧化和抗炎活性的植物。本研究评估了柚木提取物(TPE)对 PQ 诱导的大鼠肺纤维化的预防和治疗作用:我们将大鼠分为五组,每组八只。第一组和第二组分别接受生理盐水和 PQ(20 毫克/千克,静脉注射)治疗。三至五组在注射 PQ 前一周开始灌胃 TPE(50、100 和 200 毫克/千克),并在注射 PQ 后持续三周:结果:我们的研究结果表明,PQ 会明显增加肺部丙二醛、一氧化氮、羟脯氨酸、肺指数、Ashcroft 评分、红细胞堆积和炎症细胞浸润。此外,PQ 还会降低过氧化氢酶和谷胱甘肽过氧化物酶的活性以及谷胱甘肽的含量。苏木精-伊红和马森三色染色结果表明,PQ 破坏了肺实质,并形成了 PF(pConclusion):目前的调查表明,用 TPE 治疗可减少和逆转 PQ 诱导的 PF,这可能是由于 TPE 中含有酚类化合物。
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Protective potential effects of hydroalcoholic extract of Teucrium polium L. (Lamiaceae) against paraquat-induced lung fibrosis: An experimental study in rats.

Objective: Paraquat (PQ) is a highly toxic herbicide that causes pulmonary fibrosis (PF), and no specific antidote is available against it. Teucrium polium L. is a plant that exhibits antioxidant and anti-inflammatory activities. The present study evaluates the preventive and therapeutic effects of T. polium extract (TPE) against PQ-induced lung fibrosis in rats.

Materials and methods: We divided rats into five groups of eight. Groups one and two received saline and PQ (20 mg/kg, i.p.), respectively. Groups three to five were treated with TPE (50, 100, and 200 mg/kg, by gavage) started one week before PQ administration and lasted three weeks after PQ administration.

Results: Our findings showed that PQ significantly increased lung malondialdehyde, nitric oxide, hydroxyproline, lung index, Ashcroft score, red blood cells accumulation, and inflammatory cell infiltration. Moreover, PQ decreased catalase and glutathione peroxidase activities and glutathione content. The results of hematoxylin-eosin and Masson's trichrome staining indicated that PQ destroyed lung parenchyma and developed PF (p<0.05 to p<0.001). Gavage with TPE significantly improved biochemical and histological abnormalities induced by PQ in rats (p<0.05 to p<0.001).

Conclusion: The current survey indicated that treatment with TPE could reduce and reverse PQ-induced PF, which may be due to the phenolic compounds present in TPE.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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