补充肉桂对脂肪因子和食欲调节激素的影响:随机临床试验的系统回顾。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-09-01 DOI:10.22038/AJP.2022.21538
Alireza Gheflati, Naseh Pahlavani, Elyas Nattagh-Eshtivani, Zahra Namkhah, Mohammad Ghazvinikor, Golnaz Ranjbar, Mostafa Shahraki Jazinaki, Abdolreza Norouzy
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引用次数: 0

摘要

目的:肉桂是从肉桂树的内皮中提取的。最近的研究表明,肉桂是一种安全且经济有效的治疗方法,可改善体重、血脂、胰岛素抵抗和血压。本系统综述旨在总结肉桂补充剂对脂肪因子和食欲调节激素的影响:我们使用 PubMed、Scopus、ISI Web of Science 和 Google Scholar 等数据库对截至 2022 年 3 月的文献进行了全面检索。通过 Cochrane 协作组织的偏倚风险评估工具对符合条件的研究进行了质量评估:本系统综述包括六项临床试验研究(363 名参与者),其中只有一项研究针对儿童,两项调查针对肥胖参与者。研究发现,补充肉桂后,瘦素和粘脂水平会下降。三项研究中有两项对脂肪连素水平进行了检测,结果显示食用肉桂对这一参数的影响不明显。两项研究评估了胃泌素水平,发现补充肉桂后胃泌素水平有所上升。补充肉桂对其他生物标志物(如葡萄糖依赖性促胰岛素多肽、胰高血糖素样肽 1 和抵抗素)的影响并不一致:本系统综述的结果表明,补充肉桂对胃泌素水平的影响越来越大,而对瘦素和粘脂水平的影响则越来越小。然而,由于研究结果存在争议,还需要更多的临床数据来阐明肉桂对脂肪因子水平的有益影响。
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The effects of cinnamon supplementation on adipokines and appetite-regulating hormones: A systematic review of randomized clinical trials.

Objective: Cinnamon is extracted from the inner bark of Cinnamomum trees. Recent studies have indicated that cinnamon is a safe and cost-effective treatment for improving body weight, lipid profiles, insulin resistance, and blood pressure. This systematic review aimed to summarize the effect of cinnamon supplementation on adipokines and appetite-regulating hormones.

Materials and methods: This comprehensive literature search was conducted using databases such as PubMed, Scopus, ISI Web of Science, and Google Scholar up to March 2022 without any limitation. The quality of eligible studies was evaluated through the Cochrane Collaboration's tool for assessing the risk of bias.

Results: This systematic review included six clinical trial studies (363 participants), among which, only one study was performed on children, and two investigations were conducted on obese participants. A decreasing effect was found in the level of leptin and visfatin after cinnamon supplementation. Two out of three studies examined adiponectin levels and revealed non-significant effects of cinnamon consumption on this parameter. Two studies evaluated ghrelin levels and found an increase after cinnamon supplementation. The result of cinnamon supplementation on other biomarkers such as glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and resistin was inconsistent.

Conclusion: The result of this systematic review indicated the increasing effect of cinnamon supplementation on ghrelin levels and decreasing effect on leptin and visfatin levels. However, more clinical data are required to clarify the beneficial effects of cinnamon on adipokines levels due to the controversial findings of the studies.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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