原核途径的影响:痴呆症和认知障碍。

Aditya Singh, Vaseem A Ansari, Tarique Mahmood, Farogh Ahsan, Shubhrat Maheshwari
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引用次数: 0

摘要

神经退行性疾病,如阿尔茨海默病、帕金森病和朊病毒病,其特征是正常的可溶性蛋白质或肽转化为聚集的淀粉样纤维。这些疾病会导致特定类型神经元的永久性丧失,因而是无法治愈的毁灭性疾病。本文提到的记忆问题动物模型研究有助于我们了解大脑的健康和功能。神经退行性疾病通常会导致认知障碍和痴呆症,随着全球人均寿命的延长,这种疾病正变得越来越普遍。这些疾病会导致严重的神经损伤和神经元死亡,使人极度衰弱。探索和了解这些复杂的疾病,有助于深入了解维持大脑健康所必需的基本过程。探索神经退行性疾病的复杂机制不仅有望找到潜在的治疗方法,还能增进我们对大脑基本健康和功能的了解。通过揭示这些疾病的复杂性,研究人员可以为诊断、治疗以及最终改善神经退行性疾病患者的生活铺平道路。
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Repercussion of Primary Nucleation Pathway: Dementia and Cognitive Impairment.

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and prion disease, are characterized by the conversion of normally soluble proteins or peptides into aggregated amyloidal fibrils. These diseases result in the permanent loss of specific types of neurons, making them incurable and devastating. Research on animal models of memory problems mentioned in this article contributes to our knowledge of brain health and functionality. Neurodegenerative disorders, which often lead to cognitive impairment and dementia, are becoming more prevalent as global life expectancy increases. These diseases cause severe neurological impairment and neuronal death, making them highly debilitating. Exploring and understanding these complex diseases offer significant insights into the fundamental processes essential for maintaining brain health. Exploring the intricate mechanisms underlying neurodegenerative diseases not only holds promise for potential treatments but also enhances our understanding of fundamental brain health and functionality. By unraveling the complexities of these disorders, researchers can pave the way for advancements in diagnosis, treatment, and ultimately, improving the lives of individuals affected by neurodegenerative diseases.

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来源期刊
Current aging science
Current aging science Medicine-Geriatrics and Gerontology
CiteScore
3.90
自引率
0.00%
发文量
40
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