长期接受阿片类药物治疗的慢性疼痛患者对阿片类药物减量的态度。

Rami Jabakhanji, Freesia Tokunaga, Gaelle Rached, Andrew David Vigotsky, James W Griffith, Thomas Schnitzer, A Vania Apkarian
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摘要

慢性疼痛和阿片类药物成瘾的流行相互影响,可能会加剧各自的病情。尽管疗效一般,但美国仍有数百万慢性疼痛患者将阿片类药物作为治疗疼痛的主要药物。美国疾病控制中心建议逐渐减少阿片类药物的用量,以降低慢性疼痛患者对阿片类药物产生依赖的风险。然而,即使有医生的监督,减量也会带来额外的伤害。因此,许多疼痛科临床医生对进行阿片类药物减量仍持矛盾态度。在此,我们从长期服用阿片类药物的慢性疼痛患者的角度调查了他们对此问题的态度。我们询问了 127 名长期服用阿片类药物(10.3 +/- 8.2 年)的慢性疼痛患者(疼痛持续时间 = 13.5 +/- 9.6 年),他们主要服用氢可酮或羟考酮。66%的参与者表示 "非常 "或 "非常 "有兴趣参加阿片类药物减量研究。患者强调了在阿片类药物减量过程中控制疼痛的重要性,50% 以上的患者还担心会出现渴求症状。在持续背痛程度较高的参与者中,减量的愿望和对疼痛控制的担忧都更为明显。这项研究表明,大多数使用阿片类药物的慢性疼痛患者都希望减少阿片类药物的用量。然而,他们担心失去对慢性疼痛的控制。这些结果意味着医生和患者可以采取一些策略,帮助双方参与阿片类药物的减量治疗。
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Attitudes of chronic pain patients on long-term opioid therapy toward opioid tapering.
The chronic pain and opioid addiction epidemics interact with each other, potentially exacerbating each respective condition. Despite having modest efficacy, millions of chronic pain patients in the USA continue to use opioids as their primary source of pain management. The Centers for Disease Control recommends opioid tapering to diminish the risk of opioid dependence in chronic pain patients. However, tapering, even with physician oversight, can introduce additional harm. Thus, many pain clinicians remain ambivalent about undertaking opioid tapering. Here, we surveyed attitudes on the topic from the viewpoint of chronic pain patients who have been consuming opioids over long duration. We queried 127 chronic pain patients (pain duration = 13.5 +/- 9.6 years) on long-term opioids (10.3 +/- 8.2 years), primarily consuming hydrocodone or oxycodone. Sixty-six percent of participants were ″very″ or ″extremely″ interested in participating in an opioid tapering study. Patients emphasized the importance of controlling their pain during opioid tapering, and over 50% were also worried about craving symptoms. Both the desire for tapering and the worry of pain control were more pronounced in participants with a higher magnitude of ongoing back pain. The study demonstrates that most chronic pain patients using opioids are interested in decreasing opioid consumption. Yet, they worry about losing control of their chronic pain. These results imply patient-physician strategies that may aid the engagement of both parties in opioid tapering.
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