纳米结构碳纤维材料的特性及其用于生产医疗用片状肠吸收剂的工艺特点

IF 0.9 4区 材料科学 Q3 MATERIALS SCIENCE, CERAMICS Powder Metallurgy and Metal Ceramics Pub Date : 2023-12-20 DOI:10.1007/s11106-023-00393-2
V. P. Serhieiev, I. V. Kononko, N. V. Boshytska, V. D. Klipov
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引用次数: 0

摘要

我们的研究团队利用一种固相热解纳米结构活性碳纤维材料,开发了一种用于生产医疗用片状纳米结构纤维肠道吸附剂的实验技术。研究了药丸中作为有效吸附成分的主要活性成分的特性。根据苯蒸汽的吸收情况,采用干燥器法对多孔结构参数进行了检测,而比表面积则采用布鲁瑙尔-艾美特-泰勒(BET)法进行了分析。分光光度法用于测定溶液中吸附剂的浓度。使用扫描电子显微镜(Superprobe-733 X 射线显微分析仪,日本 JEOL 公司)研究了样品的微观结构。能量色散 X 射线分析提供了有关样品化学成分和生物相容性的数据,可作为一项综合指标。实验测试了肠吸附剂生产过程中关键阶段的条件。分析了不同类型的粘合剂对片剂装填工艺性能和试验肠溶丸特性的影响。所开发工艺的新颖之处在于使用具有特殊特性的材料生产肠道吸附剂,其结构中存在的结合碳纳米形式促进了这种材料的使用。提出了改进工艺操作的建议,如降低压实速度,同时增加片剂在压力下的保持时间,从而导致应变的重新分布。还有人建议在压制过程中使用纯度为 10 级的平面冲头,以防止粘连。因此,我们的研究团队开发出了具有其主要成分--纳米结构活性纤维碳材料--典型特征的片状肠吸附剂,作为吸附范围相对较广的不同化合物的有效吸附剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Properties of Nanostructured Carbon Fiber Material and Process Features of Its Use in Producing Tableted Enterosorbent for Medical Applications

An experimental technique was developed for the production of tableted nanostructured fibrous enterosorbent for medical applications using a nanostructured activated carbon fiber material of solid-phase pyrolytic origin, created by our research team. The properties of the main active ingredient in the pills, as an effective adsorbing component, were studied. The porous structure parameters were examined with the desiccator method based on the absorption of benzene vapors, while the specific surface area was analyzed with the Brunauer–Emmett–Teller (BET) method. Spectrophotometric methods were employed to determine the concentration of the sorbate in solutions. The microstructure of the samples was studied using a scanning electron microscope (Superprobe-733 X-ray microanalyzer, JEOL, Japan). Energy-dispersive X-ray analysis provided data on the chemical composition and biocompatibility of the samples, serving as an integral indicator. Conditions for the key stages in the enterosorbent production process were experimentally tested. The influence of different types of binders on the process properties of the tablet charge and on the characteristics of test enterosorbent pills was analyzed. The novelty of the developed process was the use of material with special characteristics, promoted by bound carbon nanoforms present in its structure, for enterosorbent production. Improvements in the process operations were proposed, such as decreasing the compaction speed and simultaneously increasing the time the tablet charge was kept under pressure, leading to the redistribution of strains. It was proposed that the compaction process be conducted using punches with a flat surface of purity class 10 to prevent sticking. Therefore, our research team developed tableted enterosorbent with typical features of its main component—nanostructured activated fibrous carbon material—as an effective adsorbent for a relatively wide range of different compounds.

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来源期刊
Powder Metallurgy and Metal Ceramics
Powder Metallurgy and Metal Ceramics 工程技术-材料科学:硅酸盐
CiteScore
1.90
自引率
20.00%
发文量
43
审稿时长
6-12 weeks
期刊介绍: Powder Metallurgy and Metal Ceramics covers topics of the theory, manufacturing technology, and properties of powder; technology of forming processes; the technology of sintering, heat treatment, and thermo-chemical treatment; properties of sintered materials; and testing methods.
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