性别化荷尔蒙二元论与 "荷尔蒙依赖性癌症 "类别的发展,1940-1980 年

IF 0.9 2区 哲学 Q4 HEALTH CARE SCIENCES & SERVICES Bulletin of the History of Medicine Pub Date : 2023-12-19 DOI:10.1353/bhm.2023.a915270
Gina Surita
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引用次数: 0

摘要

摘要:本文探讨了 "激素依赖性癌症 "这一类别的确立,这一类别在二十世纪中叶左右被确定为由特定激素维持的癌症。对前列腺癌和乳腺癌的激素治疗方法进行比较后发现,"激素依赖性癌症 "作为一个生物医学类别,其起源依赖于将雄激素和雌激素作为健康与疾病的性别激素二元对立面的假设。20 世纪 30 年代,癌症研究人员声称 "女性性激素"(雌激素)会加重乳腺癌,而 "男性性激素"(雄激素)则会预防乳腺癌。20 世纪 40 年代初,查尔斯-哈金斯博士将相反的逻辑应用于人类前列腺癌的治疗,他认定前列腺癌是 "激素依赖性 "的。在随后的几十年里,"激素依赖性 "在人类乳腺癌中也得到了认可,雌激素在乳腺癌的致病、诊断和治疗讨论中占据了重要位置。雌激素与乳腺癌之间的密切联系促使人们对这两个生物医学范畴进行重新解释。
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Gendered Hormonal Binaries and the Development of the Category of "Hormone-Dependent Cancers," 1940-1980

summary:

This article considers the establishment of the category of "hormone-dependent cancers," identified around the middle of the twentieth century as cancers sustained by particular hormones. A comparison of hormonal treatments for prostate cancer and those for breast cancer reveals that the genesis of "hormone-dependent cancer" as a biomedical category relied upon assumptions that cast androgens and estrogens as opposing ends of a gendered hormonal binary of health and disease. In the 1930s, cancer researchers claimed "female sex hormones" (estrogens) exacerbated breast cancer and "male sex hormones" (androgens) prevented it. In the early 1940s, Dr. Charles Huggins applied the opposite logic to the treatment of human prostate cancer, which he determined to be "hormone-dependent." As "hormone dependency" was also recognized in human breast cancer over the subsequent decades, estrogen claimed a prominent place in discussions of breast cancer's causation, diagnosis, and treatment. This close association between estrogen and breast cancer contributed to reinterpretations of both biomedical categories.

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来源期刊
Bulletin of the History of Medicine
Bulletin of the History of Medicine 医学-科学史与科学哲学
CiteScore
0.90
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: A leading journal in its field for more than three quarters of a century, the Bulletin spans the social, cultural, and scientific aspects of the history of medicine worldwide. Every issue includes reviews of recent books on medical history. Recurring sections include Digital Humanities & Public History and Pedagogy. Bulletin of the History of Medicine is the official publication of the American Association for the History of Medicine (AAHM) and the Johns Hopkins Institute of the History of Medicine.
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