S Comi, G Lanzolla, G Cosentino, M N Maglionico, C Posarelli, F Menconi, F Santini, R Elisei, M Marinò
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Here we investigated the possible association between IgG4 and GO.</p><p><strong>Methods: </strong>Retrospective investigation in 297 patients with Graves' disease (GD), 152 with GO.</p><p><strong>Primary outcome: </strong>prevalence of IgG4 ≥ 135 mg/dL (cut-off for IgG4-RD).</p><p><strong>Secondary objectives: </strong>(1) serum IgG4 concentrations; (2) IgG4/IgG ratio; (3) prevalence of IgG4/IgG ratio ≥ 8.0%; (4) relationship between IgG4 and eye features; (5) relationship between IgG4 and anti-TSH receptor antibodies (TRAbs).</p><p><strong>Results: </strong>Because GO patients had lower FT3 concentrations, we evaluated the main objectives in the second and third FT3 quartiles subpopulation, in which there were no relevant differences between patients with (n = 81) or without GO (n = 67) for baseline parameters. Within this population, the prevalence of IgG4 levels ≥ 135 mg/dL did not differ between patients without and with GO (17.9% vs 17.3%). No difference was observed concerning IgG4 concentrations, prevalence of IgG4/IgG ≥ 8.0%, and IgG4/IgG ratio. There was no relationship between IgG4 and eye features and no correlation between IgG4 levels and TRAb was found.</p><p><strong>Conclusions: </strong>Our results suggest that, within GD, there is no relationship between serum IgG4 and GO.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"IgG4 serum levels in Graves' orbitopathy.\",\"authors\":\"S Comi, G Lanzolla, G Cosentino, M N Maglionico, C Posarelli, F Menconi, F Santini, R Elisei, M Marinò\",\"doi\":\"10.1007/s40618-023-02265-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>IgG4-related disease (IgG4-RD) can involve many organs, including thyroid and orbital tissues. A link between IgG4, Graves' disease (GD) and Graves' orbitopathy (GO) has been proposed, but results are conflicting. Here we investigated the possible association between IgG4 and GO.</p><p><strong>Methods: </strong>Retrospective investigation in 297 patients with Graves' disease (GD), 152 with GO.</p><p><strong>Primary outcome: </strong>prevalence of IgG4 ≥ 135 mg/dL (cut-off for IgG4-RD).</p><p><strong>Secondary objectives: </strong>(1) serum IgG4 concentrations; (2) IgG4/IgG ratio; (3) prevalence of IgG4/IgG ratio ≥ 8.0%; (4) relationship between IgG4 and eye features; (5) relationship between IgG4 and anti-TSH receptor antibodies (TRAbs).</p><p><strong>Results: </strong>Because GO patients had lower FT3 concentrations, we evaluated the main objectives in the second and third FT3 quartiles subpopulation, in which there were no relevant differences between patients with (n = 81) or without GO (n = 67) for baseline parameters. Within this population, the prevalence of IgG4 levels ≥ 135 mg/dL did not differ between patients without and with GO (17.9% vs 17.3%). No difference was observed concerning IgG4 concentrations, prevalence of IgG4/IgG ≥ 8.0%, and IgG4/IgG ratio. There was no relationship between IgG4 and eye features and no correlation between IgG4 levels and TRAb was found.</p><p><strong>Conclusions: </strong>Our results suggest that, within GD, there is no relationship between serum IgG4 and GO.</p>\",\"PeriodicalId\":48802,\"journal\":{\"name\":\"Journal of Endocrinological Investigation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Endocrinological Investigation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40618-023-02265-3\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Endocrinological Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40618-023-02265-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的IgG4相关疾病（IgG4-RD）可累及许多器官，包括甲状腺和眼眶组织。有人提出了IgG4、巴塞杜氏病（GD）和巴塞杜氏眼眶病（GO）之间的联系，但结果并不一致。在此，我们研究了IgG4与GO之间可能存在的关联：主要结果：IgG4≥135 mg/dL（IgG4-RD的临界值）的患病率。次要目标：(1) 血清IgG4浓度；(2) IgG4/IgG比率；(3) IgG4/IgG比率≥8.0%的患病率；(4) IgG4与眼部特征的关系；(5) IgG4与抗TSH受体抗体（TRAbs）的关系：由于GO患者的FT3浓度较低，我们对第二和第三FT3四分位数亚群的主要目标进行了评估，在这些亚群中，GO患者（81人）和非GO患者（67人）的基线参数没有相关差异。在这一人群中，IgG4 水平≥ 135 mg/dL 的患病率在无 GO 和有 GO 的患者之间没有差异（17.9% vs 17.3%）。在 IgG4 浓度、IgG4/IgG ≥ 8.0% 的患病率和 IgG4/IgG 比值方面，未观察到差异。IgG4与眼部特征之间没有关系，IgG4水平与TRAb之间也没有相关性：我们的研究结果表明，在 GD 中，血清 IgG4 与 GO 之间没有关系。
Objective: IgG4-related disease (IgG4-RD) can involve many organs, including thyroid and orbital tissues. A link between IgG4, Graves' disease (GD) and Graves' orbitopathy (GO) has been proposed, but results are conflicting. Here we investigated the possible association between IgG4 and GO.
Methods: Retrospective investigation in 297 patients with Graves' disease (GD), 152 with GO.
Primary outcome: prevalence of IgG4 ≥ 135 mg/dL (cut-off for IgG4-RD).
Secondary objectives: (1) serum IgG4 concentrations; (2) IgG4/IgG ratio; (3) prevalence of IgG4/IgG ratio ≥ 8.0%; (4) relationship between IgG4 and eye features; (5) relationship between IgG4 and anti-TSH receptor antibodies (TRAbs).
Results: Because GO patients had lower FT3 concentrations, we evaluated the main objectives in the second and third FT3 quartiles subpopulation, in which there were no relevant differences between patients with (n = 81) or without GO (n = 67) for baseline parameters. Within this population, the prevalence of IgG4 levels ≥ 135 mg/dL did not differ between patients without and with GO (17.9% vs 17.3%). No difference was observed concerning IgG4 concentrations, prevalence of IgG4/IgG ≥ 8.0%, and IgG4/IgG ratio. There was no relationship between IgG4 and eye features and no correlation between IgG4 levels and TRAb was found.
Conclusions: Our results suggest that, within GD, there is no relationship between serum IgG4 and GO.
期刊介绍：
The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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