Pub Date : 2026-03-23DOI: 10.1007/s40618-026-02858-8
Luigi di Filippo, Umberto Terenzi, Simona Bolamperti, Camilla Bechini, Simonetta Bossoni, Marco Campaniolo, Licia Gifuni, Mauro Doga, Andrea Giustina
{"title":"Chronic cholecalciferol supplementation and adequate vitamin D status are associated with reduced risk of Long COVID.","authors":"Luigi di Filippo, Umberto Terenzi, Simona Bolamperti, Camilla Bechini, Simonetta Bossoni, Marco Campaniolo, Licia Gifuni, Mauro Doga, Andrea Giustina","doi":"10.1007/s40618-026-02858-8","DOIUrl":"https://doi.org/10.1007/s40618-026-02858-8","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1007/s40618-026-02860-0
Giulia Fiore, Asli Altayeva, Simona Panelli, Diego De Zan, Lodovico Sterzi, Valeria Calcaterra, Martina Tosi, Franco Folli, Gianvincenzo Zuccotti, Francesco Comandatore, Elvira Verduci
{"title":"Synergic effect of diet and polysaccharide-based complex administration in the treatment of children and adolescents with metabolically unhealthy obesity: the Polymets Study.","authors":"Giulia Fiore, Asli Altayeva, Simona Panelli, Diego De Zan, Lodovico Sterzi, Valeria Calcaterra, Martina Tosi, Franco Folli, Gianvincenzo Zuccotti, Francesco Comandatore, Elvira Verduci","doi":"10.1007/s40618-026-02860-0","DOIUrl":"https://doi.org/10.1007/s40618-026-02860-0","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s40618-026-02856-w
Yiyang Gao, Yue Jiang, Yabing Wang, Jing Yang, Jiajia Wang, An Song, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing, Min Nie, Ou Wang
{"title":"Clinical characteristics of chinese patients with autosomal dominant hypocalcemia type 1: a single-center study.","authors":"Yiyang Gao, Yue Jiang, Yabing Wang, Jing Yang, Jiajia Wang, An Song, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing, Min Nie, Ou Wang","doi":"10.1007/s40618-026-02856-w","DOIUrl":"https://doi.org/10.1007/s40618-026-02856-w","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-07DOI: 10.1007/s40618-026-02825-3
Yangming Qu, Yan Wang, Yulong Zhang, Hui Wu, Yan Yao
{"title":"POLK and KCNK17 as novel candidate genes for type 2 diabetes via stress response and ion channel regulation.","authors":"Yangming Qu, Yan Wang, Yulong Zhang, Hui Wu, Yan Yao","doi":"10.1007/s40618-026-02825-3","DOIUrl":"https://doi.org/10.1007/s40618-026-02825-3","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-07DOI: 10.1007/s40618-026-02835-1
Seohyun Kim, Minkyeong Kim, Sang Ho Park, Soojin Park, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Gyuri Kim
{"title":"Feasibility of a semiautomated, individualized coaching intervention for glycemic management in adults with type 1 diabetes: a pilot randomized controlled trial.","authors":"Seohyun Kim, Minkyeong Kim, Sang Ho Park, Soojin Park, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Gyuri Kim","doi":"10.1007/s40618-026-02835-1","DOIUrl":"https://doi.org/10.1007/s40618-026-02835-1","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-03DOI: 10.1007/s40618-026-02846-y
Antonio Matrone, Carla Gambale, Liborio Torregrossa, Alessandro Prete, Teresa Rago, Valeria Bottici, Virginia Cappagli, Leonardo Rossi, Clara Ugolini, Gabriele Materazzi, Rossella Elisei
Context: Although the diagnostic performance of calcitonin (CTN) in revealing medullary thyroid carcinoma (MTC) has been widely demonstrated, to date, neck ultrasound (neck US) and FNAC remain the first-line tools in searching for malignancy in thyroid nodules.
Objective: This study aims to determine which tool is more effective at suggesting MTC among preoperative CTN values and FNAC, compared with the estimated risk of malignancy at neck US according to the 5 main risk stratification systems (RSS), in a population of patients with already diagnosed MTC.
Methods: We evaluated preoperative serum CTN, FNAC, and neck US data in 104 patients with sporadic MTC (2014-2020) managed at the Unit of Endocrinology of the Pisa University Hospital, Italy.
Results: According to the neck US RSS, 59.6% of patients were classified as the intermediate-low suspicion (ILS) and 40.4% as the high suspicion (HS) group. FNAC, performed according to clinical judgment in 85/104 (81.7%) cases, was diagnostic of MTC in only 45.9% of cases. Moreover, according to the guidelines, 39 (62.9%) nodules in the ILS and 14 (33.3%) in the HS group would not even be submitted for FNAC. Of note, most of these MTCs had tumor dimensions > 1 cm and/or lymph node metastases. Conversely, the preoperative CTN values suggested at least a suspicion of MTC in both US risk groups and across all MTC US dimension categories, including microcarcinomas.
Conclusions: Among patients with a confirmed diagnosis of MTC, serum CTN values were the most reliable parameter, outperforming ultrasound features and FNAC in diagnostic accuracy. Delaying or failing to diagnose MTC is undesirable if the aim is to achieve early diagnosis and effective treatment of these patients.
{"title":"Comparison of pre-operative calcitonin, FNAC, and ultrasound risk stratification systems in patients with medullary thyroid carcinoma.","authors":"Antonio Matrone, Carla Gambale, Liborio Torregrossa, Alessandro Prete, Teresa Rago, Valeria Bottici, Virginia Cappagli, Leonardo Rossi, Clara Ugolini, Gabriele Materazzi, Rossella Elisei","doi":"10.1007/s40618-026-02846-y","DOIUrl":"https://doi.org/10.1007/s40618-026-02846-y","url":null,"abstract":"<p><strong>Context: </strong>Although the diagnostic performance of calcitonin (CTN) in revealing medullary thyroid carcinoma (MTC) has been widely demonstrated, to date, neck ultrasound (neck US) and FNAC remain the first-line tools in searching for malignancy in thyroid nodules.</p><p><strong>Objective: </strong>This study aims to determine which tool is more effective at suggesting MTC among preoperative CTN values and FNAC, compared with the estimated risk of malignancy at neck US according to the 5 main risk stratification systems (RSS), in a population of patients with already diagnosed MTC.</p><p><strong>Methods: </strong>We evaluated preoperative serum CTN, FNAC, and neck US data in 104 patients with sporadic MTC (2014-2020) managed at the Unit of Endocrinology of the Pisa University Hospital, Italy.</p><p><strong>Results: </strong>According to the neck US RSS, 59.6% of patients were classified as the intermediate-low suspicion (ILS) and 40.4% as the high suspicion (HS) group. FNAC, performed according to clinical judgment in 85/104 (81.7%) cases, was diagnostic of MTC in only 45.9% of cases. Moreover, according to the guidelines, 39 (62.9%) nodules in the ILS and 14 (33.3%) in the HS group would not even be submitted for FNAC. Of note, most of these MTCs had tumor dimensions > 1 cm and/or lymph node metastases. Conversely, the preoperative CTN values suggested at least a suspicion of MTC in both US risk groups and across all MTC US dimension categories, including microcarcinomas.</p><p><strong>Conclusions: </strong>Among patients with a confirmed diagnosis of MTC, serum CTN values were the most reliable parameter, outperforming ultrasound features and FNAC in diagnostic accuracy. Delaying or failing to diagnose MTC is undesirable if the aim is to achieve early diagnosis and effective treatment of these patients.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-02DOI: 10.1007/s40618-026-02843-1
Irene Bruno, Luisa De Sanctis, Nadia Edvige Foligno, Federica Giambò, Stefano Mora, Mattia Parolin, Giuseppe Vezzoli
{"title":"Optimizing diagnosis and management of patients with ENPP1 deficiency: an expert opinion.","authors":"Irene Bruno, Luisa De Sanctis, Nadia Edvige Foligno, Federica Giambò, Stefano Mora, Mattia Parolin, Giuseppe Vezzoli","doi":"10.1007/s40618-026-02843-1","DOIUrl":"https://doi.org/10.1007/s40618-026-02843-1","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-02DOI: 10.1007/s40618-026-02839-x
Changci Chenzhao, Min Zhu, Feng Zhang, Bingyu Xie, Jiamin Cao, Wei Xiong, Yao Tan
Purpose: Graves' orbitopathy (GO) is an autoimmune disease characterized by orbital inflammation, fibroblast activation, and adipogenesis, with limited effective therapies. This study aimed to investigate the role of biglycan (BGN) in GO pathogenesis and its underlying mechanisms.
Methods: Bioinformatic analyses were performed to identify differentially expressed genes in GO tissues. BGN protein levels were validated in orbital adipose tissues from GO patients. Functional effects of BGN were examined by overexpression or knockdown in human GO orbital fibroblasts (GO-OFs) in vitro. In vivo, a thyroid-associated ophthalmopathy (TAO) mouse model was used to evaluate the effects of Bgn knockdown on orbital fibrosis and adipogenesis.
Results: BGN expression was significantly upregulated in GO orbital tissues. In vitro, BGN overexpression promoted, while BGN knockdown attenuated, fibrosis and adipogenesis in GO-OFs. Mechanistically, BGN activated nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinase (ERK) signaling pathways. In vivo, Bgn knockdown reduced GO-like pathological features, including fibrosis and adipose expansion, and decreased NF‑κB and ERK signaling activation.
Conclusion: BGN contributes to fibrosis and adipogenesis in GO via NF‑κB and ERK signaling activation. These findings elucidate a pivotal role for BGN in GO pathogenesis and highlight its potential as a therapeutic target for GO treatment.
{"title":"Biglycan knockdown improves Graves' orbitopathy (GO)-like features via inhibiting NF-kB and ERK signaling.","authors":"Changci Chenzhao, Min Zhu, Feng Zhang, Bingyu Xie, Jiamin Cao, Wei Xiong, Yao Tan","doi":"10.1007/s40618-026-02839-x","DOIUrl":"https://doi.org/10.1007/s40618-026-02839-x","url":null,"abstract":"<p><strong>Purpose: </strong>Graves' orbitopathy (GO) is an autoimmune disease characterized by orbital inflammation, fibroblast activation, and adipogenesis, with limited effective therapies. This study aimed to investigate the role of biglycan (BGN) in GO pathogenesis and its underlying mechanisms.</p><p><strong>Methods: </strong>Bioinformatic analyses were performed to identify differentially expressed genes in GO tissues. BGN protein levels were validated in orbital adipose tissues from GO patients. Functional effects of BGN were examined by overexpression or knockdown in human GO orbital fibroblasts (GO-OFs) in vitro. In vivo, a thyroid-associated ophthalmopathy (TAO) mouse model was used to evaluate the effects of Bgn knockdown on orbital fibrosis and adipogenesis.</p><p><strong>Results: </strong>BGN expression was significantly upregulated in GO orbital tissues. In vitro, BGN overexpression promoted, while BGN knockdown attenuated, fibrosis and adipogenesis in GO-OFs. Mechanistically, BGN activated nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinase (ERK) signaling pathways. In vivo, Bgn knockdown reduced GO-like pathological features, including fibrosis and adipose expansion, and decreased NF‑κB and ERK signaling activation.</p><p><strong>Conclusion: </strong>BGN contributes to fibrosis and adipogenesis in GO via NF‑κB and ERK signaling activation. These findings elucidate a pivotal role for BGN in GO pathogenesis and highlight its potential as a therapeutic target for GO treatment.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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