通过具有成本效益的战略和艾滋病毒/艾滋病伙伴关系,降低镰状细胞性贫血在青少 年中的流行率

IF 0.2 Q4 MULTIDISCIPLINARY SCIENCES Suranaree Journal of Science and Technology Pub Date : 2023-12-20 DOI:10.55766/sujst-2023-03-e03091
Minal Chetan Thakkar, Hitesh Natvarlal Shah, Prakashbhai Hirabhai Parma, Smit Kirtikumar Sukhadiya
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引用次数: 0

摘要

本研究旨在采用经济有效的筛查方法确定阿南德人民医疗保险协会(APMS)学生中镰状细胞病的患病率,并用高效液相色谱法(HPLC)确认筛查结果。古吉拉特邦阿南德市共有 395 名学生接受了筛查,主要筛查方法是镰状细胞试验和溶解度试验。血红蛋白病携带者在艾哈迈达巴德的印度红十字会州分会通过高效液相色谱法进行诊断和确诊。对血型图进行了全面分析,并将结果列表分析。结果表明,高效液相色谱法的灵敏度、特异性和准确性均为 100%,而镰状染色试验的灵敏度为 66.66%,特异性为 97.90%,准确性为 97.21%。溶解度测试的灵敏度为 53.84%,特异度为 96.85%,准确度为 95.44%。高效液相色谱法的阳性预测值(PPV)和阴性预测值(NPV)均为 100%,而镰刀菌检测法的 PPV 为 55.55%,NPV 为 99.20%。溶解度检测的 PPV 为 36.84%,NPV 为 98.40%。总之,镰刀试验和溶解度试验成本效益高,操作简便,镰刀试验与溶解度试验相比,结果更可靠,灵敏度和特异性更高。高效液相色谱法被认为是筛查的金标准检测方法。
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PREVALENCE OF SICKLE CELL ANEMIA IN YOUTH BY COST EFFECTIVE STRATEGY ALONG WITH HPLC
This study aimed to determine the prevalence of sickle cell disease among students of Anand People’s Medicare Society (APMS) using cost-effective screening methods and confirming the results with high-performance liquid chromatography (HPLC). A total of 395 students from Anand, Gujarat, were screened using the sickling test and solubility test as primary screening methods. Haemoglobinopathies carriers were diagnosed and confirmed using HPLC at the Indian Red Cross Society, State Branch in Ahmedabad. Complete hemogram analysis was performed, and the results were tabulated and analyzed. The results indicated that HPLC exhibited 100% sensitivity, specificity, and accuracy, while the sickling test demonstrated a sensitivity of 66.66%, specificity of 97.90%, and accuracy of 97.21%. The solubility test showed a sensitivity of 53.84%, specificity of 96.85%, and accuracy of 95.44%. HPLC had a 100% positive predictive value (PPV) and negative predictive value (NPV), whereas the sickling test had a PPV of 55.55% and NPV of 99.20%. The solubility test yielded a PPV of 36.84% and NPV of 98.40%. In conclusion, the sickling test and solubility test are cost-effective and easily conducted, with the sickling test providing more reliable results with higher sensitivity and specificity compared to the solubility test. HPLC is considered the gold standard test for screening.
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Suranaree Journal of Science and Technology
Suranaree Journal of Science and Technology MULTIDISCIPLINARY SCIENCES-
CiteScore
0.30
自引率
50.00%
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