宁泌泰胶囊通过抗氧化和抗炎改善慢性前列腺炎男性不育患者的精液质量

Xiaoyu Wu, Zhen Ye, Li-hua Li, Huiping Zhang, Xunbing Huang, Jingsong Chai, Xinzong Zhang
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Subsequently, assessments were conducted on parameters including sperm concentration, forward progressive motility, total motility, oxidative and anti-oxidative indicators, as well as the concentration of interleukin-8 (IL-8) in seminal plasma before and after the treatment period.\nResults: Compared to pre-treatment, forward progressive motility and total motility of the semen increased significantly (37.15% ± 18.77% vs. 45.44% ± 19.08%, P < 0.05 and 42.56% ± 21.22% vs. 51.64% ± 19.48%, P < 0.05). And the expression of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) increased significantly after treatment as well (11.36 μmol/L ± 3.28 μmol/L vs. 12.79 μmol/L ± 2.87 μmol/L, P < 0.05 and 9.34 U/mL ± 3.22 U/mL vs. 11.21 U/mL ± 4.87 U/mL, P < 0.05). 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摘要

目的:观察宁泌泰胶囊对慢性前列腺炎(CP)不育患者精液参数的影响,并探讨其机制:方法:研究共纳入43名确诊为慢性前列腺炎的患者,他们服用宁泌泰胶囊(每次4粒),疗程为6周。随后,对治疗前后精浆中的精子浓度、前向运动能力、总运动能力、氧化和抗氧化指标以及白细胞介素-8(IL-8)浓度等参数进行评估:与治疗前相比,精液的前向运动能力和总运动能力显著增加(37.15% ± 18.77% vs. 45.44% ± 19.08%,P < 0.05;42.56% ± 21.22% vs. 51.64% ± 19.48%,P < 0.05)。超氧化物歧化酶(SOD)和总抗氧化能力(T-AOC)的表达在治疗后也显著增加(11.36 μmol/L ± 3.28 μmol/L vs. 12.79 μmol/L ± 2.87 μmol/L,P < 0.05;9.34 U U/mL ± 3.22 U/mL vs. 11.21 U U/mL ± 4.87 U/mL,P < 0.05)。此外,治疗后丙二醛(MDA)和IL-8的表达也显著下降(41.06 μmol/L ± 24.39 μmol/L vs. 32.17 μmol/L ± 15.04 μmol/L,P < 0.05;79.69 ng/L ± 26.24 ng/L vs. 61.35 ng/L ± 23.41 ng/L,P < 0.05)。治疗后精子浓度和精子DNA碎片指数无明显差异(P > 0.05):结论:宁神胶囊能增强精液的抗氧化能力,下调精液中细胞因子的表达,从而改善CP不育患者的精液指标。
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Ningmitai capsule improves the semen quality of male infertile with chronic prostatitis by antioxidant and anti-inflammatory
Aim: To observe the effects of Ningmitai capsule on semen parameters of infertile patients with chronic prostatitis (CP) and explore the mechanisms. Methods: A total of 43 patients diagnosed with CP were included in the study and administered Ningmitai capsules (4 capsules per dose) for a duration of 6 weeks. Subsequently, assessments were conducted on parameters including sperm concentration, forward progressive motility, total motility, oxidative and anti-oxidative indicators, as well as the concentration of interleukin-8 (IL-8) in seminal plasma before and after the treatment period. Results: Compared to pre-treatment, forward progressive motility and total motility of the semen increased significantly (37.15% ± 18.77% vs. 45.44% ± 19.08%, P < 0.05 and 42.56% ± 21.22% vs. 51.64% ± 19.48%, P < 0.05). And the expression of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) increased significantly after treatment as well (11.36 μmol/L ± 3.28 μmol/L vs. 12.79 μmol/L ± 2.87 μmol/L, P < 0.05 and 9.34 U/mL ± 3.22 U/mL vs. 11.21 U/mL ± 4.87 U/mL, P < 0.05). In addition, the expression of malondialdehyde (MDA) and IL-8 decreased significantly after treatment (41.06 μmol/L ± 24.39 μmol/L vs. 32.17 μmol/L ± 15.04 μmol/L, P < 0.05 and 79.69 ng/L ± 26.24 ng/L vs. 61.35 ng/L ± 23.41 ng/L, P < 0.05). No significant difference in sperm concentration and sperm DNA fragmentation index was observed after the treatment (P > 0.05). Conclusions: Ningmitai capsule can enhance the antioxidant capacity and down-regulate the expression of cytokines in the semen, thereby improving the semen parameters of infertile patients with CP.
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