{"title":"牛尿对毒死蜱诱导的氧化应激的缓解作用","authors":"Shelly Sharma, Sukanya Mehra, Pooja Chadha","doi":"10.18311/ti/2023/v30i4/33071","DOIUrl":null,"url":null,"abstract":"The present study was planned to evaluate the mitigating effect of cow urine against the detrimental effects induced by Chlorpyrifos (CPF), an organophosphate pesticide, in different tissues of rat. The LD50 was determined and 1/4th of LD50 i.e., 38mg/ kg b.wt was selected for treatment. Sexually mature rats weighing 120±10 g was orally administered with selected dose and cow urine. After 24, 48 and 72 hours biochemical analysis was done using different biomarkers in different tissues. In light of available data, it was deduced that CPF has propensity to cause marked perturbations in the antioxidant enzymes. Further, cow urine mitigated the oxidative stress induced by CPF in different tissues. Thus, this study emphasizes the importance of use of cow urine as a natural source of antioxidants which could be beneficial in the therapeutic world for the treatment of various disorders implicating oxidative stress.","PeriodicalId":23205,"journal":{"name":"Toxicology International","volume":"11 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mitigating Effect of Cow Urine against Chlorpyrifos Induced Oxidative Stress\",\"authors\":\"Shelly Sharma, Sukanya Mehra, Pooja Chadha\",\"doi\":\"10.18311/ti/2023/v30i4/33071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study was planned to evaluate the mitigating effect of cow urine against the detrimental effects induced by Chlorpyrifos (CPF), an organophosphate pesticide, in different tissues of rat. The LD50 was determined and 1/4th of LD50 i.e., 38mg/ kg b.wt was selected for treatment. Sexually mature rats weighing 120±10 g was orally administered with selected dose and cow urine. After 24, 48 and 72 hours biochemical analysis was done using different biomarkers in different tissues. In light of available data, it was deduced that CPF has propensity to cause marked perturbations in the antioxidant enzymes. Further, cow urine mitigated the oxidative stress induced by CPF in different tissues. Thus, this study emphasizes the importance of use of cow urine as a natural source of antioxidants which could be beneficial in the therapeutic world for the treatment of various disorders implicating oxidative stress.\",\"PeriodicalId\":23205,\"journal\":{\"name\":\"Toxicology International\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicology International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18311/ti/2023/v30i4/33071\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18311/ti/2023/v30i4/33071","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Mitigating Effect of Cow Urine against Chlorpyrifos Induced Oxidative Stress
The present study was planned to evaluate the mitigating effect of cow urine against the detrimental effects induced by Chlorpyrifos (CPF), an organophosphate pesticide, in different tissues of rat. The LD50 was determined and 1/4th of LD50 i.e., 38mg/ kg b.wt was selected for treatment. Sexually mature rats weighing 120±10 g was orally administered with selected dose and cow urine. After 24, 48 and 72 hours biochemical analysis was done using different biomarkers in different tissues. In light of available data, it was deduced that CPF has propensity to cause marked perturbations in the antioxidant enzymes. Further, cow urine mitigated the oxidative stress induced by CPF in different tissues. Thus, this study emphasizes the importance of use of cow urine as a natural source of antioxidants which could be beneficial in the therapeutic world for the treatment of various disorders implicating oxidative stress.
期刊介绍：
Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
