Nakul Y Sampat, A. Valand, Rakshak Dinesh Prajapati, Pervaiz Ahmed Khan, Pradeep Wagh
{"title":"偶然的关联:急性髓性白血病与丝虫病--病例报告","authors":"Nakul Y Sampat, A. Valand, Rakshak Dinesh Prajapati, Pervaiz Ahmed Khan, Pradeep Wagh","doi":"10.18231/j.jdpo.2023.052","DOIUrl":null,"url":null,"abstract":"Acute myeloid leukemia (AML) is a hematological malignancy characterized by the abnormal proliferation of myeloid cells in the bone marrow. Symptoms include fatigue, frequent infections, easy bruising or bleeding, and shortness of breath. Filariasis is a parasitic infection caused by filarial worms (a nematode) transmitted through mosquito bites from infected individuals, leading to chronic lymphatic dysfunction, lymphedema, hydrocele, and elephantiasis. Here, we present the case of a 38-year-old male who was diagnosed with acute myeloid leukemia without maturation (M1) and an incidental finding of microfilariae in a peripheral blood smear. Interestingly, there was no accompanying eosinophilia in this case. This coexistence of filariasis and AML poses diagnostic challenges, as eosinophilia may not be a reliable indicator. Treatment options include Diethylcarbamazine, Ivermectin, Albendazole and Doxycycline for filarial and chemotherapy and stem cell transplantation for AML (M1). The prognosis for the patient is poor.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Incidental association: Acute myeloid leukemia and filariasis - A case report\",\"authors\":\"Nakul Y Sampat, A. Valand, Rakshak Dinesh Prajapati, Pervaiz Ahmed Khan, Pradeep Wagh\",\"doi\":\"10.18231/j.jdpo.2023.052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute myeloid leukemia (AML) is a hematological malignancy characterized by the abnormal proliferation of myeloid cells in the bone marrow. Symptoms include fatigue, frequent infections, easy bruising or bleeding, and shortness of breath. Filariasis is a parasitic infection caused by filarial worms (a nematode) transmitted through mosquito bites from infected individuals, leading to chronic lymphatic dysfunction, lymphedema, hydrocele, and elephantiasis. Here, we present the case of a 38-year-old male who was diagnosed with acute myeloid leukemia without maturation (M1) and an incidental finding of microfilariae in a peripheral blood smear. Interestingly, there was no accompanying eosinophilia in this case. This coexistence of filariasis and AML poses diagnostic challenges, as eosinophilia may not be a reliable indicator. Treatment options include Diethylcarbamazine, Ivermectin, Albendazole and Doxycycline for filarial and chemotherapy and stem cell transplantation for AML (M1). The prognosis for the patient is poor.\",\"PeriodicalId\":364340,\"journal\":{\"name\":\"IP Journal of Diagnostic Pathology and Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IP Journal of Diagnostic Pathology and Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18231/j.jdpo.2023.052\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IP Journal of Diagnostic Pathology and Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18231/j.jdpo.2023.052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Incidental association: Acute myeloid leukemia and filariasis - A case report
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the abnormal proliferation of myeloid cells in the bone marrow. Symptoms include fatigue, frequent infections, easy bruising or bleeding, and shortness of breath. Filariasis is a parasitic infection caused by filarial worms (a nematode) transmitted through mosquito bites from infected individuals, leading to chronic lymphatic dysfunction, lymphedema, hydrocele, and elephantiasis. Here, we present the case of a 38-year-old male who was diagnosed with acute myeloid leukemia without maturation (M1) and an incidental finding of microfilariae in a peripheral blood smear. Interestingly, there was no accompanying eosinophilia in this case. This coexistence of filariasis and AML poses diagnostic challenges, as eosinophilia may not be a reliable indicator. Treatment options include Diethylcarbamazine, Ivermectin, Albendazole and Doxycycline for filarial and chemotherapy and stem cell transplantation for AML (M1). The prognosis for the patient is poor.