开发一种空气辅助分散液-液微萃取方法,作为评估邻苯二甲酸盐暴露的重要生物监测工具

IF 1.1 Q4 CHEMISTRY, ANALYTICAL Brazilian Journal of Analytical Chemistry Pub Date : 2023-12-15 DOI:10.30744/brjac.2179-3425.ar-91-2023
Bruno Rocha, M. Gallimberti, Marília Souza, João Ximenez, A. Martino-Andrade, José Domingo, F. Barbosa Jr.
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引用次数: 0

摘要

近年来,可为健康风险评估提供信息和帮助更新的邻苯二甲酸盐流行病学研究数量迅速增加。开发可靠、快速的分析方法来测定邻苯二甲酸酯单酯(m-PAEs)是评估接触情况的重要生物监测工具。本研究开发了一种快速灵敏的方法来测定人体尿样中的 15 种 m-PAEs,作为评估暴露的有效生物标志物。该方法采用了空气辅助分散液液微萃取和液相色谱-质谱联用技术。为了确定最佳萃取条件和建立影响萃取效率的变量模型,采用了中心复合可旋转设计和响应面方法。在优化条件下,该方法获得了良好的线性(R > 0.99)、令人满意的日内和日间准确度(97-111%)以及日内和日间精密度(RSD < 14%)。该方法灵敏度高,适用于评估邻苯二甲酸盐的体内暴露量。通过筛查巴西 50 名儿童的尿液,评估了所建议程序的适用性。结果发现,与使用个人护理产品和饮食有关的几种 m-PAEs 的检测频率和尿液浓度都很高。
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Development of an Air-assisted Dispersive Liquid-Liquid Microextraction Method as a Valuable Biomonitoring Tool for Exposure Assessment of Phthalates
In recent years, the number of epidemiological studies on phthalates that can inform and help update health risk assessments has grown rapidly. Developing reliable and rapid analytical methods for determining phthalate monoesters (m-PAEs) is an important biomonitoring tool for assessing exposure. In this study, a fast and sensitive method was developed to determine 15 m-PAEs in human urine samples as effective biomarkers for exposure assessment. Air-assisted dispersive liquid-liquid microextraction and liquid chromatography coupled to mass spectrometry were used. In order to determine the optimal conditions and model the variables influencing the extraction efficiency, a central composite rotatable design coupled with response surface methodology was used. Under the optimized conditions, the method achieved good linearities (R > 0.99), satisfactory intra- and inter-day accuracies (97–111%), and intra- and inter-day precision (RSD < 14%). The proposed procedure allowed the detection of the m-PAEs with limit of detection values between 0.02 and 0.10 ng mL-1, which makes the method sensitive and appropriate for assessing internal exposure to phthalates. The applicability of the proposed procedure was evaluated by screening fifty children’s urine from Brazil. High detection frequencies and urinary concentrations of several m-PAEs associated with using personal care products and diet were found.
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CiteScore
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自引率
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发文量
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期刊介绍: BrJAC is dedicated to the diffusion of significant and original knowledge in all branches of Analytical Chemistry, and is addressed to professionals involved in science, technology and innovation projects at universities, research centers and in industry.
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