轮廓图对估计胃肠道间质瘤复发风险的影响:辅助治疗的适应症:近畿 GIST 登记分析。

IF 6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gastric Cancer Pub Date : 2024-03-01 Epub Date: 2023-12-25 DOI:10.1007/s10120-023-01444-8
Ryugo Teranishi, Tsuyoshi Takahashi, Shinsuke Sato, Katsunobu Sakurai, Kentaro Kishi, Hisahiro Hosogi, Takuya Nakai, Yukinori Kurokawa, Junya Fujita, Toshirou Nishida, Seiichi Hirota, Toshimasa Tsujinaka
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引用次数: 0

摘要

简介:等高线图可对个别 GIST 患者术后 10 年内的复发进行风险分类:等高线图可对个别患者术后 10 年内的 GIST 复发风险进行分类。虽然日本指南中提到了等高线图,但在日本患者中,等高线图在确定辅助治疗适应症方面的作用和用途仍不明确。本研究旨在调查等高线图在日本 GIST 患者中的有效性,并探索辅助治疗的新策略:分析了近畿 GIST 研究小组在 2003 年至 2012 年间登记在册的 1426 例日本 GIST 患者。本研究纳入了接受 R0 手术且未进行围手术期治疗的患者。结果:共有994名患者完成了这项研究。我们利用等高线图对患者进行了验证。GIST分类为0-10%、10-20%、20-40%、40-60%、60-80%、80-90%和90-100%的患者的5年无复发生存率分别为98.1%、96.6%、92.3%、48.0%、37.3%、41.0%和42.4%。我们证实,通过等高线图进行的分类能很好地反映复发预测。此外,在按美国国立卫生研究院共识标准(m-NIHC)分层的高危组中,以 40% 为分界点的 10 年 RFS 率有显著变化(0-40% 组 vs. 40-100% 组,88.7% vs. 50.4%):88.7% vs. 50.3%, p 结论:等高线图能有效预测个体复发率。它可能有助于高危患者联合 m-NIHC 制定个体化策略。
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The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry.

Introduction: Contour maps enable risk classification of GIST recurrence in individual patients within 10 postoperative years. Although contour maps have been referred to in Japanese guidelines, their usefulness and role in determining indications for adjuvant therapy is still unclear in Japanese patients. The aims of this study are to investigate the validity of contour maps in Japanese patients with GIST and explore the new strategy for adjuvant therapy.

Materials and methods: A total of 1426 Japanese GIST patients who were registered to the registry by the Kinki GIST Study Group between 2003 and 2012 were analyzed. Patients who had R0 surgery without perioperative therapy were included in this study. The accuracy of contour maps was validated.

Results: Overall, 994 patients have concluded this study. Using contour maps, we validated the patients. The 5-year recurrence-free survival rates of patients within the GIST classification groups of 0-10%, 10-20%, 20-40%, 40-60%, 60-80%, 80-90%, and 90-100% were 98.1%, 96.6%, 92.3%, 48.0%, 37.3%, 41.0% and 42.4%, respectively. We confirmed that this classification by contour maps was well reflected recurrence prediction. Further, in the high-risk group stratified by the modified National Institutes of Health consensus criteria (m-NIHC), the 10-year RFS rate was remarkably changed at a cutoff of 40% (0-40% group vs. 40-100% group: 88.7% vs. 50.3%, p < 0.001).

Conclusion: Contour maps are effective in predicting individual recurrence rates. And it may be useful for the decision of individual strategy for high-risk patients combined with m-NIHC.

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来源期刊
Gastric Cancer
Gastric Cancer 医学-胃肠肝病学
CiteScore
14.70
自引率
2.70%
发文量
80
审稿时长
6-12 weeks
期刊介绍: Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.
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